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TCL1 Is Overexpressed in Patients Affected by Adult T-Cell Leukemias¹

Laboratory of Vascular Pathology IDI-IRCCS, Roma 00167, Italy [M. G. N., G. R.]; Kimmel Cancer Institute and Kimmel Cancer Center, Philadelphia, Pennsylvania 19107 [L. V., C. L., C. M. C.]; Department of Human Biopathology, University "La Sapienza," Rome 00161, Italy [A. S.]; and Research Center for Immunodeficiency Virus, Kyoto University, Kyoto, Japan [K. I., T. U.]

Among mature postthymic T-cell leukemias, adult T-cell leukemia (ATL) has characteristic clinicopathological entities. The association with the human T-cell leukemia/lymphotropic virus type I is one of the distinctive etiopathogenetic features of this disease. However, unlike other acute transforming retroviruses, the human T-cell leukemia/lymphotropic virus type I lacks an oncogene within its genome. Other human postthymic leukemias, such as T-prolymphocytic leukemias, involve mostly the CD4 cellular subset and share many similarities to ATLs (aggressive course, cutaneous involvement, CD4⁺, CD29⁺, CD45RA^- phenotype, and alphanaphthyl-acetate esterase positivity). A chromosomal rearrangement at 14q32.1, involved in translocations or inversions with either the / locus [t(14;14)(q11;q32.1), inv14(q11;q32.1)], or the ß-chain locus of the T-cell receptor [t(7;14)(q35;q32.1)] is found. These rearrangements disregulate a gene, TCL1, located at the 14q32.1 region, that we show is physiologically expressed in CD4/CD8 double-negative thymocyte cells, but not in more differentiated CD4⁺ and CD8⁺ subpopulations. Here, using molecular and immunocytochemical analysis, we report that TCL1 is also overexpressed in 10 of 10 ATL specimens, indicating that this gene may play an important role in the pathogenesis of this disease.

¹ Supported in part by Human Frontier Grant 350/96 M (to C. M. C., G. R., and T. U.) and by Grant CA 39860 from the National Cancer Institute (to C. M. C.).

² To whom requests for reprints should be addressed, at Laboratory of Vascular Pathology, Istituto Dermopatico dell' Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico, Via Monti di Creta 104, 00167 Roma, Italy. E-mail: gianni.russo@area.ba.cnr.it.

Received 9/ 2/97. Accepted 10/29/97.

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