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Suppression of Preneoplastic Changes in the Intestine of Rats Fed Low Levels of Polyamines

Contrat Jeune Formation Institut National de la Santé et de la Recherche Médicale 95-09, Institut de Recherche contre les Cancers de l'Appareil Digestif, 1 place de l'hôpital, BP 426, 67091 Strasbourg-cedex, France

Administration for 7 days of an enteral diet that is naturally deficient in polyamines strikingly reduces the preneoplastic changes observed in the intestines of adult Wistar rats previously treated with the carcinogen 1,2-dimethylhydrazine. On the contrary, supplementing the enteral diet with spermidine favors preneoplastic development. The effects of the low-polyamine diet included a 40% decline in the putrescine content of the intestinal mucosa, a significant decrease in the turnover rate of the epithelial cells from the crypts to villus tip in the ileum, and a 2-fold reduction in the number of abnormal colonic crypts. The experimental data support the view that it might be of interest to control the dietary intake of polyamines in the clinical management of cancer patients.

¹ To whom requests for reprints should be addressed. Phone: (33) 0388119023; Fax: (33) 0388119097.

Received 10/24/96. Accepted 1/ 4/97.

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