Cancer Research CTRC-AACR San Antonio Breast Cancer Symposium Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 57, 615-619, February 15, 1997]
© 1997 American Association for Cancer Research
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ahmad, M.
Right arrow Articles by Alnemri, E. S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Ahmad, M.
Right arrow Articles by Alnemri, E. S.

CRADD, a Novel Human Apoptotic Adaptor Molecule for Caspase-2, and FasL/Tumor Necrosis Factor Receptor-interacting Protein RIP1

Manzoor Ahmad, Srinivasa M. Srinivasula, Lijuan Wang, Robert V. Talanian, Gerald Litwack, Teresa Fernandes-Alnemri and Emad S. Alnemri2

Center for Apoptosis Research and the Kimmel Cancer Institute, Jefferson Medical College, Philadelphia, Pennsylvania 19107 [M. A., S. M. S., L. W., G. L., T. F-A., E. S. A.], and BASF Bioresearch Corporation, Worcester, Massachusetts 01605 [R. V. T.]

FADD/MORT1 is a death domain (DD)-containing adaptor/signaling molecule that interacts with the intracellular DD of FAS/APO-I (CD95) and tumor necrosis factor receptor 1 and the prodomain of caspase-8 (Mch5/MACH/FLICE). FADD engagement of caspase-8 presumably activates this caspase and leads to apoptosis. Another DD-containing adaptor/signaling molecule, CRADD, was identified and was shown to induce apoptosis. CRADD has a dual-domain structure similar to that of FADD. It has an NH2-terminal caspase homology domain that interacts with caspase-2 and a COOH-terminal DD that interacts with RIP. CRADD is constitutively expressed in many tissues and thus could play a role in regulating apoptosis in mammalian cells.

1 Supported by Research Grants AG 13487 and AI 35035 from the NIH and in part by a research grant from IDUN Pharmaceuticals. M. S. and S. M. S. contributed equally to this work.

2 To whom requests for reprints should be addressed, at Kimmel Cancer Institute, Jefferson Medical College, Bluemle Life Sciences Building, 233 South 10th Stre et, Philadelphia, PA 19107. Phone: (215) 503-4632; Fax: (215) 923-1098; E-mail: E_Alnemri@lac.jci.tju.edu.

Received 12/ 2/96. Accepted 1/ 9/97.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. C. Peluffo, R. L. Stouffer, and M. Tesone
Activity and expression of different members of the caspase family in the rat corpus luteum during pregnancy and postpartum
Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1215 - E1223.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
N. M. Mhaidat, Y. Wang, K. A. Kiejda, X. D. Zhang, and P. Hersey
Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2
Mol. Cancer Ther., February 1, 2007; 6(2): 752 - 761.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
M. C Peluffo, L. Bussmann, R. L Stouffer, and M. Tesone
Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle.
Reproduction, September 1, 2006; 132(3): 465 - 475.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
I. N. Lavrik, A. Golks, S. Baumann, and P. H. Krammer
Caspase-2 is activated at the CD95 death-inducing signaling complex in the course of CD95-induced apoptosis
Blood, July 15, 2006; 108(2): 559 - 565.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
V. Temkin, Q. Huang, H. Liu, H. Osada, and R. M. Pope
Inhibition of ADP/ATP Exchange in Receptor-Interacting Protein-Mediated Necrosis.
Mol. Cell. Biol., March 1, 2006; 26(6): 2215 - 2225.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Berube, L.-M. Boucher, W. Ma, A. Wakeham, L. Salmena, R. Hakem, W.-C. Yeh, T. W. Mak, and S. Benchimol
Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD
PNAS, October 4, 2005; 102(40): 14314 - 14320.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Lamkanfi, K. D'hondt, L. Vande Walle, M. van Gurp, G. Denecker, J. Demeulemeester, M. Kalai, W. Declercq, X. Saelens, and P. Vandenabeele
A Novel Caspase-2 Complex Containing TRAF2 and RIP1
J. Biol. Chem., February 25, 2005; 280(8): 6923 - 6932.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Daniel, M. B. Arvelo, V. I. Patel, C. R. Longo, G. Shrikhande, T. Shukri, J. Mahiou, D. W. Sun, C. Mottley, S. T. Grey, et al.
A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation
Blood, October 15, 2004; 104(8): 2376 - 2384.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
J. C. Reed, K. S. Doctor, and A. Godzik
The Domains of Apoptosis: A Genomics Perspective
Sci. Signal., June 29, 2004; 2004(239): re9 - re9.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. Tinel and J. Tschopp
The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress
Science, May 7, 2004; 304(5672): 843 - 846.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Zettl, T. Rudiger, M.-A. Konrad, A. Chott, I. Simonitsch-Klupp, R. Sonnen, H. K. Muller-Hermelink, and G. Ott
Genomic Profiling of Peripheral T-Cell Lymphoma, Unspecified, and Anaplastic Large T-Cell Lymphoma Delineates Novel Recurrent Chromosomal Alterations
Am. J. Pathol., May 1, 2004; 164(5): 1837 - 1848.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
Y.-C. Fu, C.-S. Chi, S.-C. Yin, B. Hwang, Y.-T. Chiu, and S.-L. Hsu
Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of {beta}-adrenergic and caspase-2 pathways
Cardiovasc Res, January 1, 2004; 61(1): 143 - 151.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
S. DELHALLE, A. DUVOIX, M. SCHNEKENBURGER, F. MORCEAU, M. DICATO, and M. DIEDERICH
An Introduction to the Molecular Mechanisms of Apoptosis
Ann. N.Y. Acad. Sci., December 1, 2003; 1010(1): 1 - 8.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
E. M. Creagh and S. J. Martin
Cell Stress-Associated Caspase Activation: Intrinsically Complex?
Sci. Signal., March 25, 2003; 2003(175): pe11 - pe11.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
W. Martinet, M. W.M. Knaapen, G. R.Y. De Meyer, A. G. Herman, and M. M. Kockx
Overexpression of the Anti-Apoptotic Caspase-2 Short Isoform in Macrophage-Derived Foam Cells of Human Atherosclerotic Plaques
Am. J. Pathol., March 1, 2003; 162(3): 731 - 736.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Wittig, M. Nessling, R. D. Will, J. Mollenhauer, R. Salowsky, E. Munstermann, M. Schick, H. Helmbach, B. Gschwendt, B. Korn, et al.
Candidate Genes for Cross-Resistance against DNA-damaging Drugs
Cancer Res., November 15, 2002; 62(22): 6698 - 6705.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. D. Robertson, M. Enoksson, M. Suomela, B. Zhivotovsky, and S. Orrenius
Caspase-2 Acts Upstream of Mitochondria to Promote Cytochrome c Release during Etoposide-induced Apoptosis
J. Biol. Chem., August 9, 2002; 277(33): 29803 - 29809.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Paroni, C. Henderson, C. Schneider, and C. Brancolini
Caspase-2 Can Trigger Cytochrome c Release and Apoptosis from the Nucleus
J. Biol. Chem., April 19, 2002; 277(17): 15147 - 15161.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Guo, S. M. Srinivasula, A. Druilhe, T. Fernandes-Alnemri, and E. S. Alnemri
Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria
J. Biol. Chem., April 12, 2002; 277(16): 13430 - 13437.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Razmara, S. M. Srinivasula, L. Wang, J.-L. Poyet, B. J. Geddes, P. S. DiStefano, J. Bertin, and E. S. Alnemri
CARD-8 Protein, a New CARD Family Member That Regulates Caspase-1 Activation and Apoptosis
J. Biol. Chem., April 12, 2002; 277(16): 13952 - 13958.
[Abstract] [Full Text] [PDF]

Home page
 Protein Sci.Home page
W. J. Fairbrother, N. C. Gordon, E. W. Humke, K. M. O'rourke, M. A. Starovasnik, J.-P. Yin, and V. M. Dixit
The PYRIN domain: A member of the death domain-fold superfamily
Protein Sci., September 1, 2001; 10(9): 1911 - 1918.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Droin, F. Bichat, C. Rebe, A. Wotawa, O. Sordet, A. Hammann, R. Bertrand, and E. Solary
Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells
Blood, March 15, 2001; 97(6): 1835 - 1844.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Virtaneva, F. A. Wright, S. M. Tanner, B. Yuan, W. J. Lemon, M. A. Caligiuri, C. D. Bloomfield, A. de la Chapelle, and R. Krahe
Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics
PNAS, January 30, 2001; 98(3): 1124 - 1129.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Droin, M. Beauchemin, E. Solary, and R. Bertrand
Identification of a Caspase-2 Isoform that Behaves as an Endogenous Inhibitor of the Caspase Cascade
Cancer Res., December 1, 2000; 60(24): 7039 - 7047.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
J. C. Reed
Mechanisms of Apoptosis
Am. J. Pathol., November 1, 2000; 157(5): 1415 - 1430.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
B. B Aggarwal
Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappa B
Ann Rheum Dis, November 1, 2000; 59(90001): i6 - 16.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. A. Davidovich and I. B. Roninson
Pleiotropic Resistance to DNA-interactive Drugs Is Associated with Increased Expression of Genes Involved in DNA Replication, Repair, and Stress Response
Cancer Res., September 1, 2000; 60(18): 5027 - 5030.
[Abstract] [Full Text]

Home page
 BloodHome page
T. G. Willis and M. J. S. Dyer
The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies
Blood, August 1, 2000; 96(3): 808 - 822.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Tatsuta, A. Shiraishi, and J. D. Mountz
The Prodomain of Caspase-1 Enhances Fas-mediated Apoptosis through Facilitation of Caspase-8 Activation
J. Biol. Chem., May 5, 2000; 275(19): 14248 - 14254.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Ye, X. Xie, L. Tarassishin, and M. S. Horwitz
Regulation of the NF-kappa B Activation Pathway by Isolated Domains of FIP3/IKKgamma , a Component of the Ikappa B-alpha Kinase Complex
J. Biol. Chem., March 24, 2000; 275(13): 9882 - 9889.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. L. Perkins, G. Fang, C. N. Kim, and K. N. Bhalla
The Role of Apaf-1, Caspase-9, and Bid Proteins in Etoposide- or Paclitaxel-induced Mitochondrial Events during Apoptosis
Cancer Res., March 1, 2000; 60(6): 1645 - 1653.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
T. Dilla, J. A. Velasco, D. L. Medina, J. F. Gonzalez-Palacios, and P. Santisteban
The MDM2 Oncoprotein Promotes Apoptosis in p53-Deficient Human Medullary Thyroid Carcinoma Cells
Endocrinology, January 1, 2000; 141(1): 420 - 429.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-L. Chan, K.-O. Tan, L. Zhang, K. S. Y. Yee, F. Ronca, M.-Y. Chan, and V. C. Yu
F1Aalpha , a Death Receptor-binding Protein Homologous to the Caenorhabditis elegans Sex-determining Protein, FEM-1, Is a Caspase Substrate That Mediates Apoptosis
J. Biol. Chem., November 5, 1999; 274(45): 32461 - 32468.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. Chen, H.-G. Wang, S. M. Srinivasula, E. S. Alnemri, and N. R. Cooper
B Cell Apoptosis Triggered by Antigen Receptor Ligation Proceeds Via a Novel Caspase-Dependent Pathway
J. Immunol., September 1, 1999; 163(5): 2483 - 2491.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. B. Wolf and D. R. Green
Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Proteinases
J. Biol. Chem., July 16, 1999; 274(29): 20049 - 20052.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. M. Srinivasula, M. Ahmad, J.-h. Lin, J.-L. Poyet, T. Fernandes-Alnemri, P. N. Tsichlis, and E. S. Alnemri
CLAP, a Novel Caspase Recruitment Domain-containing Protein in the Tumor Necrosis Factor Receptor Pathway, Regulates NF-kappa B Activation and Apoptosis
J. Biol. Chem., June 18, 1999; 274(25): 17946 - 17954.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Mori, K. Murakami-Mori, S. Nakamura, A. Ashkenazi, and B. Bonavida
Sensitization of AIDS-Kaposi's Sarcoma Cells to Apo-2 Ligand-Induced Apoptosis by Actinomycin D
J. Immunol., May 1, 1999; 162(9): 5616 - 5623.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. F. Cheema, S. B. Wade, M. Sata, K. Walsh, F. Sohrabji, and R. C. Miranda
Fas/Apo [Apoptosis]-1 and Associated Proteins in the Differentiating Cerebral Cortex: Induction of Caspase-Dependent Cell Death and Activation of NF-kappa B
J. Neurosci., March 1, 1999; 19(5): 1754 - 1770.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
E. A. Slee, M. T. Harte, R. M. Kluck, B. B. Wolf, C. A. Casiano, D. D. Newmeyer, H.-G. Wang, J. C. Reed, D. W. Nicholson, E. S. Alnemri, et al.
Ordering the Cytochrome c-initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9-dependent Manner
J. Cell Biol., January 25, 1999; 144(2): 281 - 292.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. Ashkenazi and V. M. Dixit
Death Receptors: Signaling and Modulation
Science, August 28, 1998; 281(5381): 1305 - 1308.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
A. Haunstetter and S. Izumo
Apoptosis : Basic Mechanisms and Implications for Cardiovascular Disease
Circ. Res., June 15, 1998; 82(11): 1111 - 1129.
[Full Text] [PDF]

Home page
 Genes Dev.Home page
V. Cryns and J. Yuan
Proteases to die for
Genes & Dev., June 1, 1998; 12(11): 1551 - 1570.
[Full Text]

Home page
 J. Biol. Chem.Home page
S. M. Srinivasula, M. Ahmad, M. MacFarlane, Z. Luo, Z. Huang, T. Fernandes-Alnemri, and E. S. Alnemri
Generation of Constitutively Active Recombinant Caspases-3 and -6 by Rearrangement of Their Subunits
J. Biol. Chem., April 24, 1998; 273(17): 10107 - 10111.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Lotem and L. Sachs
Cytokine suppression of protease activation in wild-type p53-dependent and p53-independent apoptosis
PNAS, August 19, 1997; 94(17): 9349 - 9353.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. V. Goltsev, A. V. Kovalenko, E. Arnold, E. E. Varfolomeev, V. M. Brodianskii, and D. Wallach
CASH, a Novel Caspase Homologue with Death Effector Domains
J. Biol. Chem., August 8, 1997; 272(32): 19641 - 19644.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. M. Srinivasula, M. Ahmad, S. Ottilie, F. Bullrich, S. Banks, Y. Wang, T. Fernandes-Alnemri, C. M. Croce, G. Litwack, K. J. Tomaselli, et al.
FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis
J. Biol. Chem., July 25, 1997; 272(30): 18542 - 18545.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Bertin, Y. Guo, L. Wang, S. M. Srinivasula, M. D. Jacobson, J.-L. Poyet, S. Merriam, M.-Q. Du, M. J. S. Dyer, K. E. Robison, et al.
CARD9 Is a Novel Caspase Recruitment Domain-containing Protein That Interacts With BCL10/CLAP and Activates NF-kappa B
J. Biol. Chem., December 22, 2000; 275(52): 41082 - 41086.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-L. Poyet, S. M. Srinivasula, and E. S. Alnemri
vCLAP, a Caspase-recruitment Domain-containing Protein of Equine Herpesvirus-2, Persistently Activates the Ikappa B Kinases through Oligomerization of IKKgamma
J. Biol. Chem., January 26, 2001; 276(5): 3183 - 3187.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-L. Poyet, S. M. Srinivasula, M. Tnani, M. Razmara, T. Fernandes-Alnemri, and E. S. Alnemri
Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1
J. Biol. Chem., July 20, 2001; 276(30): 28309 - 28313.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Luschen, S. Ussat, G. Scherer, D. Kabelitz, and S. Adam-Klages
Sensitization to Death Receptor Cytotoxicity by Inhibition of Fas-associated Death Domain Protein (FADD)/Caspase Signaling. REQUIREMENT OF CELL CYCLE PROGRESSION
J. Biol. Chem., August 4, 2000; 275(32): 24670 - 24678.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Bertin, L. Wang, Y. Guo, M. D. Jacobson, J.-L. Poyet, S. M. Srinivasula, S. Merriam, P. S. DiStefano, and E. S. Alnemri
CARD11 and CARD14 Are Novel Caspase Recruitment Domain (CARD)/Membrane-associated Guanylate Kinase (MAGUK) Family Members that Interact with BCL10 and Activate NF-kappa B
J. Biol. Chem., April 6, 2001; 276(15): 11877 - 11882.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Bonfoco, E. Li, F. Kolbinger, and N. R. Cooper
Characterization of a Novel Proapoptotic Caspase-2- and Caspase-9-binding Protein
J. Biol. Chem., July 27, 2001; 276(31): 29242 - 29250.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Zhao, S. Li, E. E. Childs, D. K. Kuharsky, and X.-M. Yin
Activation of Pro-death Bcl-2 Family Proteins and Mitochondria Apoptosis Pathway in Tumor Necrosis Factor-alpha -induced Liver Injury
J. Biol. Chem., July 13, 2001; 276(29): 27432 - 27440.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Wang, Y. Guo, W.-J. Huang, X. Ke, J.-L. Poyet, G. A. Manji, S. Merriam, M. A. Glucksmann, P. S. DiStefano, E. S. Alnemri, et al.
CARD10 Is a Novel Caspase Recruitment Domain/Membrane-associated Guanylate Kinase Family Member That Interacts with BCL10 and Activates NF-kappa B
J. Biol. Chem., June 8, 2001; 276(24): 21405 - 21409.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1997 by the American Association for Cancer Research.