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Department of Obstetrics and Gynecology [S. P, S. K. C.], Department of Internal Medicine, Division of Hematology and Oncology [M. C., M. B-C., K. A. F.], Department of Microbiology and Immunology [H. Z.], and The Lucille Parker Markey Cancer Center, [S. P., M. C., M. B-C., H. Z., K. A. F., S. K. C.], University of Kentucky Medical Center, Lexington, Kentucky 40536-0096
Carcinoembryonic antigen (CEA) is a tumor-associated antigen expressed on most gastrointestinal adenocarcinomas and is a putative target for cancer immunotherapy. We developed a murine monoclonal anti-idiotype (anti-Id) antibody, 3H1, which mimics a specific epitope of CEA, for cancer immunotherapy. In this study, the efficacy of 3H1 as a tumor vaccine was evaluated in a murine tumor model. In this model, the murine colorectal cancer cell line MC-38 was transduced with the human CEA gene and injected into syngeneic C57BL/6 (H-2b) mice. Immunization of naive mice with 3H1 conjugated with keyhole limpet hemocyanin Freund's adjuvant induced humoral and cellular anti-3H1 as well as anti-CEA immunity. Mice immunized with 3H1 were protected against a challenge with lethal doses of MC-38-cea, whereas no protection was observed when 3H1 vaccinated mice were challenged with CEA negative MC-38 cells or when mice were vaccinated with an unrelated anti-Id antibody and challenged with MC-38-cea cells (P < 0.003). These data demonstrate that the 3H1 vaccine can induce protective CEA-specific antitumor immunity.
1 To whom requests for reprints should be addressed, at Department of Obstetrics and Gynecology, 204 Combs Research Building, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536-0096.
Received 8/ 5/96. Accepted 12/18/96.
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