| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Charles A. Dana Division of Human Cancer Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115 [M. F. K., G. M. G., R. K.], and Departments of Pathology [M. L. J. L. R. M., H. G.] and Surgery [J. M. J.], Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115
Somatic mutations in DNA mismatch repair genes have been observed in sporadic tumors as well as cell lines and xenografts derived from such tumors implicating genetic defects of mismatch repair genes in the development of such tumors. However, the proportion of sporadic tumors in which mismatch repair genes have been inactivated has not been determined accurately. We have analyzed 66 sporadic colorectal tumors for the expression of hMLH1 by immunohistochemistry and identified 4 tumors that do not express hMLH1. These four colorectal tumors, a colon tumor cell line (SW48) and an endometrial tumor cell line (AN3CA), did not express hMLH1, despite the absence of mutations in its coding sequence. Cytosine methlation of the hMLH1 promoter region was found in these four colorectal tumors, whereas cytosine methylation of the hMLH1 promoter region was absent in adjacent normal tissue or in nine tumors that expressed hMLH1. In addition, cytosine methylation of the hMLH1 promoter region was observed in the SW48 and AN3CA cell lines that do not express hMLH1 but not in four tumor cell lines known to express hMLH1 mRNA. Our data indicate that DNA methylation is likely to be a common mode of mismatch repair gene inactivation in sporadic tumors.
1 Supported by NIH Grants CA67151 (to R. K.), CA44704 (to R. K., J. M. J., M. L., and H. G.), CA06516 (Dana-Farber Cancer Institute), and funds from the Starr Foundation (to R. K.).
2 To whom requests for reprints should be addressed, at the Charles A. Dana Division of Human Cancer Genetics, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115; Phone: (617) 632-3806; Fax: (617) 632-4326.
Received 12/13/96. Accepted 1/15/97.
This article has been cited by other articles:
|
|
 |
|
  J. Mueller, I. Gazzoli, P. Bandipalliam, J. E. Garber, S. Syngal, and R. D. Kolodner Comprehensive Molecular Analysis of Mismatch Repair Gene Defects in Suspected Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Cases Cancer Res., September 1, 2009; 69(17): 7053 - 7061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Roeckel, S. M. Woerner, M. Kloor, Y.-P. Yuan, G. Patsos, R. Gromes, J. Kopitz, and J. Gebert High Frequency of LMAN1 Abnormalities in Colorectal Tumors with Microsatellite Instability Cancer Res., January 1, 2009; 69(1): 292 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Lenz Established Biomarkers for Colon Cancer ASCO Educational Book, January 1, 2009; 2009(1): 215 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Poynter, K. D. Siegmund, D. J. Weisenberger, T. I. Long, S. N. Thibodeau, N. Lindor, J. Young, M. A. Jenkins, J. L. Hopper, J. A. Baron, et al. Molecular Characterization of MSI-H Colorectal Cancer by MLHI Promoter Methylation, Immunohistochemistry, and Mismatch Repair Germline Mutation Screening Cancer Epidemiol. Biomarkers Prev., November 1, 2008; 17(11): 3208 - 3215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Schernhammer, E. Giovannuccci, C. S. Fuchs, and S. Ogino A Prospective Study of Dietary Folate and Vitamin B and Colon Cancer According to Microsatellite Instability and KRAS Mutational Status Cancer Epidemiol. Biomarkers Prev., October 1, 2008; 17(10): 2895 - 2898. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Rodriguez, L. T. Hansen, G. Phear, J. Scorah, M. Spang-Thomsen, A. Cox, T. Helleday, and M. Meuth Thymidine Selectively Enhances Growth Suppressive Effects of Camptothecin/Irinotecan in MSI+ Cells and Tumors Containing a Mutation of MRE11 Clin. Cancer Res., September 1, 2008; 14(17): 5476 - 5483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. French, D. J. Sargent, L. J. Burgart, N. R. Foster, B. F. Kabat, R. Goldberg, L. Shepherd, H. E. Windschitl, and S. N. Thibodeau Prognostic Significance of Defective Mismatch Repair and BRAF V600E in Patients with Colon Cancer Clin. Cancer Res., June 1, 2008; 14(11): 3408 - 3415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Potapova, A. M. Hoffman, A. K. Godwin, T. Al-Saleem, and P. Cairns Promoter Hypermethylation of the PALB2 Susceptibility Gene in Inherited and Sporadic Breast and Ovarian Cancer Cancer Res., February 15, 2008; 68(4): 998 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Rauch, X. Zhong, X. Wu, M. Wang, K. H. Kernstine, Z. Wang, A. D. Riggs, and G. P. Pfeifer High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer PNAS, January 8, 2008; 105(1): 252 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sanada, M. Hidaka, Y. Takagi, T. Y. Takano, Y. Nakatsu, T. Tsuzuki, and M. Sekiguchi Modes of actions of two types of anti-neoplastic drugs, dacarbazine and ACNU, to induce apoptosis Carcinogenesis, December 1, 2007; 28(12): 2657 - 2663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Boardman, A. P. Lanier, A. J. French, K. V. Schowalter, L. J. Burgart, K. R. Koller, S. K. McDonnell, D. J. Schaid, and S. N. Thibodeau Frequency of Defective DNA Mismatch Repair in Colorectal Cancer among the Alaska Native People Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2344 - 2350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Newcomb, J. Baron, M. Cotterchio, S. Gallinger, J. Grove, R. Haile, D. Hall, J. L. Hopper, J. Jass, L. Le Marchand, et al. Colon Cancer Family Registry: An International Resource for Studies of the Genetic Epidemiology of Colon Cancer Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2331 - 2343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Shen, P. J. Catalano, A. B. Benson III, P. O'Dwyer, S. R. Hamilton, and J.-P. J. Issa Association between DNA Methylation and Shortened Survival in Patients with Advanced Colorectal Cancer Treated with 5-Fluorouracil Based Chemotherapy Clin. Cancer Res., October 15, 2007; 13(20): 6093 - 6098. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Maglietta, A. Piepoli, D. Catalano, F. Licciulli, M. Carella, S. Liuni, G. Pesole, F. Perri, and N. Ancona Statistical assessment of functional categories of genes deregulated in pathological conditions by using microarray data Bioinformatics, August 15, 2007; 23(16): 2063 - 2072. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. V. Jacinto and M. Esteller Mutator pathways unleashed by epigenetic silencing in human cancer Mutagenesis, July 1, 2007; 22(4): 247 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Malesci, L. Laghi, P. Bianchi, G. Delconte, A. Randolph, V. Torri, C. Carnaghi, R. Doci, R. Rosati, M. Montorsi, et al. Reduced Likelihood of Metastases in Patients with Microsatellite-Unstable Colorectal Cancer Clin. Cancer Res., July 1, 2007; 13(13): 3831 - 3839. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Shell, C. D. Putnam, and R. D. Kolodner Chimeric Saccharomyces cerevisiae Msh6 protein with an Msh3 mispair-binding domain combines properties of both proteins PNAS, June 26, 2007; 104(26): 10956 - 10961. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. O'Dwyer, S. G. Eckhardt, D. G. Haller, J. Tepper, D. Ahnen, S. Hamilton, A. B. Benson III, M. Rothenberg, N. Petrelli, H.-J. Lenz, et al. Priorities in Colorectal Cancer Research: Recommendations From the Gastrointestinal Scientific Leadership Council of the Coalition of Cancer Cooperative Groups J. Clin. Oncol., June 1, 2007; 25(16): 2313 - 2321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bettstetter, S. Dechant, P. Ruemmele, M. Grabowski, G. Keller, E. Holinski-Feder, A. Hartmann, F. Hofstaedter, and W. Dietmaier Distinction of Hereditary Nonpolyposis Colorectal Cancer and Sporadic Microsatellite-Unstable Colorectal Cancer through Quantification of MLH1 Methylation by Real-time PCR Clin. Cancer Res., June 1, 2007; 13(11): 3221 - 3228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Zighelboim, P. J. Goodfellow, F. Gao, R. K. Gibb, M. A. Powell, J. S. Rader, and D. G. Mutch Microsatellite Instability and Epigenetic Inactivation of MLH1 and Outcome of Patients With Endometrial Carcinomas of the Endometrioid Type J. Clin. Oncol., May 20, 2007; 25(15): 2042 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Zighelboim, P. J. Goodfellow, A. P. Schmidt, K. C. Walls, M. A. Mallon, D. G. Mutch, P. S. Yan, T. H.-M. Huang, and M. A. Powell Differential Methylation Hybridization Array of Endometrial Cancers Reveals Two Novel Cancer-Specific Methylation Markers Clin. Cancer Res., May 15, 2007; 13(10): 2882 - 2889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Brena and J. F. Costello Genome-epigenome interactions in cancer Hum. Mol. Genet., April 15, 2007; 16(R1): R96 - R105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M Grady and C. M Ulrich DNA alkylation and DNA methylation: cooperating mechanisms driving the formation of colorectal adenomas and adenocarcinomas? Gut, March 1, 2007; 56(3): 318 - 320. [Full Text] [PDF]
|
|
|
|
|
|
C. R. Boland Clinical Uses of Microsatellite Instability Testing in Colorectal Cancer: An Ongoing Challenge J. Clin. Oncol., March 1, 2007; 25(7): 754 - 756. [Full Text] [PDF]
|
|
|
|
|
|
Z. Herceg Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors Mutagenesis, March 1, 2007; 22(2): 91 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. T. Lynch, J. F. Lynch, and P. M. Lynch Toward a Consensus in Molecular Diagnosis of Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) J Natl Cancer Inst, February 21, 2007; 99(4): 261 - 263. [Full Text] [PDF]
|
|
|
|
 |
|
 F. Model, N. Osborn, D. Ahlquist, R. Gruetzmann, B. Molnar, F. Sipos, O. Galamb, C. Pilarsky, H.-D. Saeger, Z. Tulassay, et al. Identification and Validation of Colorectal Neoplasia-Specific Methylation Markers for Accurate Classification of Disease Mol. Cancer Res., February 1, 2007; 5(2): 153 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wallner, A. Herbst, A. Behrens, A. Crispin, P. Stieber, B. Goke, R. Lamerz, and F. T. Kolligs Methylation of Serum DNA Is an Independent Prognostic Marker in Colorectal Cancer Clin. Cancer Res., December 15, 2006; 12(24): 7347 - 7352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Benlloch, A. Paya, C. Alenda, X. Bessa, M. Andreu, R. Jover, A. Castells, X. Llor, F. I. Aranda, and B. Massuti Detection of BRAF V600E Mutation in Colorectal Cancer: Comparison of Automatic Sequencing and Real-Time Chemistry Methodology J. Mol. Diagn., November 1, 2006; 8(5): 540 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Minoo, K Baker, R Goswami, G Chong, W D Foulkes, A R Ruszkiewicz, M Barker, D Buchanan, J Young, and J R Jass Extensive DNA methylation in normal colorectal mucosa in hyperplastic polyposis Gut, October 1, 2006; 55(10): 1467 - 1474. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Kennedy and A. D. D'Andrea DNA Repair Pathways in Clinical Practice: Lessons From Pediatric Cancer Susceptibility Syndromes J. Clin. Oncol., August 10, 2006; 24(23): 3799 - 3808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Demokan, Y. Suoglu, D. Demir, M. Gozeler, and N. Dalay Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer Ann. Onc., June 1, 2006; 17(6): 995 - 999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Castells, A. Paya, C. Alenda, F. Rodriguez-Moranta, R. Agrelo, M. Andreu, V. Pinol, S. Castellvi-Bel, R. Jover, X. Llor, et al. Cyclooxygenase 2 expression in colorectal cancer with DNA mismatch repair deficiency. Clin. Cancer Res., March 15, 2006; 12(6): 1686 - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Fox, D. T. Leahy, R. Geraghty, H. E. Mulcahy, D. Fennelly, J. M. Hyland, D. P. O'Donoghue, and K. Sheahan Mutually Exclusive Promoter Hypermethylation Patterns of hMLH1 and O6-Methylguanine DNA Methyltransferase in Colorectal Cancer J. Mol. Diagn., February 1, 2006; 8(1): 68 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-W. Jair, K. E. Bachman, H. Suzuki, A. H. Ting, I. Rhee, R.-W. C. Yen, S. B. Baylin, and K. E. Schuebel De novo CpG Island Methylation in Human Cancer Cells Cancer Res., January 15, 2006; 66(2): 682 - 692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Matsuzaki, G. Deng, H. Tanaka, S. Kakar, S. Miura, and Y. S. Kim The Relationship between Global Methylation Level, Loss of Heterozygosity, and Microsatellite Instability in Sporadic Colorectal Cancer Clin. Cancer Res., December 15, 2005; 11(24): 8564 - 8569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Tzao, H.-S. Hsu, G.-H. Sun, H.-L. Lai, Y.-C. Wang, H.-J. Tung, C.-P. Yu, Y.-L. Cheng, and S.-C. Lee Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma J. Thorac. Cardiovasc. Surg., November 1, 2005; 130(5): 1371 - 1371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hidaka, Y. Takagi, T. Y. Takano, and M. Sekiguchi PCNA-MutS{alpha}-mediated binding of MutL{alpha} to replicative DNA with mismatched bases to induce apoptosis in human cells Nucleic Acids Res., October 4, 2005; 33(17): 5703 - 5712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Giovannucci and S. Ogino DNA Methylation, Field Effects, and Colorectal Cancer J Natl Cancer Inst, September 21, 2005; 97(18): 1317 - 1319. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hampel, W. L. Frankel, E. Martin, M. Arnold, K. Khanduja, P. Kuebler, H. Nakagawa, K. Sotamaa, T. W. Prior, J. Westman, et al. Screening for the Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) N. Engl. J. Med., May 5, 2005; 352(18): 1851 - 1860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chen, D. Ye, X. Xie, W. Lu, C. Zhu, and X. Chen PTEN Promoter Methylation and Protein Expression in Normal Early Placentas and Hydatidiform Moles Reproductive Sciences, April 1, 2005; 12(3): 214 - 217. [Abstract] [PDF]
|
|
|
|
|
|
A J M Watson Apoptosis and colorectal cancer Gut, November 1, 2004; 53(11): 1701 - 1709. [Full Text] [PDF]
|
|
|
|
|
|
D. D. Potter, J. A. Murray, J. H. Donohue, L. J. Burgart, D. M. Nagorney, J. A. van Heerden, M. F. Plevak, A. R. Zinsmeister, and S. N. Thibodeau The Role of Defective Mismatch Repair in Small Bowel Adenocarcinoma in Celiac Disease Cancer Res., October 1, 2004; 64(19): 7073 - 7077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. Lund and M. van Lohuizen Epigenetics and cancer Genes & Dev., October 1, 2004; 18(19): 2315 - 2335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Baker, Y Zhang, C Jin, and J R Jass Proximal versus distal hyperplastic polyps of the colorectum: different lesions or a biological spectrum? J. Clin. Pathol., October 1, 2004; 57(10): 1089 - 1093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E Domingo, P Laiho, M Ollikainen, M Pinto, L Wang, A J French, J Westra, T Frebourg, E Espin, M Armengol, et al. BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing J. Med. Genet., September 1, 2004; 41(9): 664 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Kambara, L A Simms, V L J Whitehall, K J Spring, C V A Wynter, M D Walsh, M A Barker, S Arnold, A McGivern, N Matsubara, et al. BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum Gut, August 1, 2004; 53(8): 1137 - 1144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-R. Li, E. I. Shagisultanova, K. Yamashita, Z. Piao, M. Perucho, and S. R. Malkhosyan Hypersensitivity of Tumor Cell Lines with Microsatellite Instability to DNA Double Strand Break Producing Chemotherapeutic Agent Bleomycin Cancer Res., July 15, 2004; 64(14): 4760 - 4767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Lei, Y. Zhu, A. Tomkinson, and L. Sun Measurement of DNA mismatch repair activity in live cells Nucleic Acids Res., July 12, 2004; 32(12): e100 - e100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gifford, J. Paul, P. A. Vasey, S. B. Kaye, and R. Brown The Acquisition of hMLH1 Methylation in Plasma DNA after Chemotherapy Predicts Poor Survival for Ovarian Cancer Patients Clin. Cancer Res., July 1, 2004; 10(13): 4420 - 4426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Deng, G.-A. Song, E. Pong, M. Sleisenger, and Y. S. Kim Promoter Methylation Inhibits APC Gene Expression by Causing Changes in Chromatin Conformation and Interfering with the Binding of Transcription Factor CCAAT-Binding Factor Cancer Res., April 15, 2004; 64(8): 2692 - 2698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C V A Wynter, M D Walsh, T Higuchi, B A Leggett, J Young, and J R Jass Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer Gut, April 1, 2004; 53(4): 573 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Mori, J. Yin, F. Sato, A. Sterian, L. A. Simms, F. M. Selaru, K. Schulmann, Y. Xu, A. Olaru, S. Wang, et al. Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning Cancer Res., April 1, 2004; 64(7): 2434 - 2438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yoshida, K. Nosaka, J.-i. Yasunaga, I. Nishikata, K. Morishita, and M. Matsuoka Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells Blood, April 1, 2004; 103(7): 2753 - 2760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Plaschke, S. Kruger, B. Jeske, F. Theissig, F. R. Kreuz, S. Pistorius, H. D. Saeger, I. Iaccarino, G. Marra, and H. K. Schackert Loss of MSH3 Protein Expression Is Frequent in MLH1-Deficient Colorectal Cancer and Is Associated with Disease Progression1 Cancer Res., February 1, 2004; 64(3): 864 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Gazzoli and R. D. Kolodner Regulation of the Human MSH6 Gene by the Sp1 Transcription Factor and Alteration of Promoter Activity and Expression by Polymorphisms Mol. Cell. Biol., November 15, 2003; 23(22): 7992 - 8007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hirasawa, D. Aoki, J. Inoue, I. Imoto, N. Susumu, K. Sugano, S. Nozawa, and J. Inazawa Unfavorable Prognostic Factors Associated with High Frequency of Microsatellite Instability and Comparative Genomic Hybridization Analysis in Endometrial Cancer Clin. Cancer Res., November 15, 2003; 9(15): 5675 - 5682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Diergaarde, H. Braam, G. N. P. van Muijen, M. J. L. Ligtenberg, F. J. Kok, and E. Kampman Dietary Factors and Microsatellite Instability in Sporadic Colon Carcinomas Cancer Epidemiol. Biomarkers Prev., November 1, 2003; 12(11): 1130 - 1136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Ward, K. Cheong, S.-L. Ku, A. Meagher, T. O'Connor, and N. J. Hawkins Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite Instability J. Clin. Oncol., October 15, 2003; 21(20): 3729 - 3736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Humbert, I. Achour, D. Lautier, G. Laurent, and B. Salles hMSH2 expression is driven by AP1-dependent regulation through phorbol-ester exposure Nucleic Acids Res., October 1, 2003; 31(19): 5627 - 5634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hahnloser, G. M. Petersen, K. Rabe, K. Snow, N. M. Lindor, L. Boardman, B. Koch, D. Doescher, L. Wang, K. Steenblock, et al. The APC E1317Q Variant in Adenomatous Polyps and Colorectal Cancers Cancer Epidemiol. Biomarkers Prev., October 1, 2003; 12(10): 1023 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. S. Li, N.-G. Kim, S. H. Kim, C. Park, H. Kim, H. J. Kang, K. H. Koh, S. N. Kim, W. H. Kim, N. K. Kim, et al. Chromosomal Imbalances in the Colorectal Carcinomas with Microsatellite Instability Am. J. Pathol., October 1, 2003; 163(4): 1429 - 1436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, J. M. Cunningham, J. L. Winters, J. C. Guenther, A. J. French, L. A. Boardman, L. J. Burgart, S. K. McDonnell, D. J. Schaid, and S. N. Thibodeau BRAF Mutations in Colon Cancer Are Not Likely Attributable to Defective DNA Mismatch Repair Cancer Res., September 1, 2003; 63(17): 5209 - 5212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Hou, M. Ji, C. Ge, J. Shen, S. Li, N. He, and Z. Lu Detection of methylation of human p16Ink4a gene 5'-CpG islands by electrochemical method coupled with linker-PCR Nucleic Acids Res., August 15, 2003; 31(16): e92 - e92. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Frazier, L. Xi, J. Zong, N. Viscofsky, A. Rashid, E. F. Wu, P. M. Lynch, C. I. Amos, and J.-P. J. Issa Association of the CpG Island Methylator Phenotype with Family History of Cancer in Patients with Colorectal Cancer Cancer Res., August 15, 2003; 63(16): 4805 - 4808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.M. Nash, M. Gimbel, J. Shia, A.T. Culliford, D.R. Nathanson, M. Ndubuisi, Y. Yamaguchi, Z.S. Zeng, F. Barany, and P.B. Paty Automated, Multiplex Assay for High-Frequency Microsatellite Instability in Colorectal Cancer J. Clin. Oncol., August 15, 2003; 21(16): 3105 - 3112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Mori, F. M. Selaru, F. Sato, J. Yin, L. A. Simms, Y. Xu, A. Olaru, E. Deacu, S. Wang, J. M. Taylor, et al. The Impact of Microsatellite Instability on the Molecular Phenotype of Colorectal Tumors Cancer Res., August 1, 2003; 63(15): 4577 - 4582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. van Rijnsoever, H. Elsaleh, D. Joseph, K. McCaul, and B. Iacopetta CpG Island Methylator Phenotype Is an Independent Predictor of Survival Benefit from 5-Fluorouracil in Stage III Colorectal Cancer Clin. Cancer Res., August 1, 2003; 9(8): 2898 - 2903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li, L. Myeroff, D. Smiraglia, M. F. Romero, T. P. Pretlow, L. Kasturi, J. Lutterbaugh, R. M. Rerko, G. Casey, J.-P. Issa, et al. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers PNAS, July 8, 2003; 100(14): 8412 - 8417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Warnick, B. Dabbas, S. J. Ilstrup, C. D. Ford, and K. A. Strait Cell Type-Dependent Regulation of hMLH1 Promoter Activity Is Influenced by the Presence of Multiple Redundant Elements Mol. Cancer Res., June 1, 2003; 1(8): 610 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. T. Mihaylova, R. S. Bindra, J. Yuan, D. Campisi, L. Narayanan, R. Jensen, F. Giordano, R. S. Johnson, S. Rockwell, and P. M. Glazer Decreased Expression of the DNA Mismatch Repair Gene Mlh1 under Hypoxic Stress in Mammalian Cells Mol. Cell. Biol., May 1, 2003; 23(9): 3265 - 3273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Segura-Pacheco, C. Trejo-Becerril, E. Perez-Cardenas, L. Taja-Chayeb, I. Mariscal, A. Chavez, C. Acuna, A. M. Salazar, M. Lizano, and A. Duenas-Gonzalez Reactivation of Tumor Suppressor Genes by the Cardiovascular Drugs Hydralazine and Procainamide and Their Potential Use in Cancer Therapy Clin. Cancer Res., May 1, 2003; 9(5): 1596 - 1603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. R. Halford, A. J. Rowan, L. Lipton, O. M. Sieber, K. Pack, H. J. W. Thomas, S. V. Hodgson, W. F. Bodmer, and I. P. M. Tomlinson Germline Mutations but Not Somatic Changes at the MYH Locus Contribute to the Pathogenesis of Unselected Colorectal Cancers Am. J. Pathol., May 1, 2003; 162(5): 1545 - 1548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Lynch and A. de la Chapelle Hereditary Colorectal Cancer N. Engl. J. Med., March 6, 2003; 348(10): 919 - 932. [Full Text] [PDF]
|
|
|
|
|
|
J. R. Jass Serrated Adenoma of the Colorectum: A Lesion with Teeth Am. J. Pathol., March 1, 2003; 162(3): 705 - 708. [Full Text] [PDF]
|
|
|
|
|
|
L. Ricciardiello, A. Goel, V. Mantovani, T. Fiorini, S. Fossi, D. K. Chang, V. Lunedei, P. Pozzato, R. M. Zagari, L. De Luca, et al. Frequent Loss of hMLH1 by Promoter Hypermethylation Leads to Microsatellite Instability in Adenomatous Polyps of Patients with a Single First-Degree Member Affected by Colon Cancer Cancer Res., February 15, 2003; 63(4): 787 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Matheson and A. G. Hall Assessment of mismatch repair function in leukaemic cell lines and blasts from children with acute lymphoblastic leukaemia Carcinogenesis, January 1, 2003; 24(1): 31 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hartmann, L. Zanardo, T. Bocker-Edmonston, H. Blaszyk, W. Dietmaier, R. Stoehr, J. C. Cheville, K. Junker, W. Wieland, R. Knuechel, et al. Frequent Microsatellite Instability in Sporadic Tumors of the Upper Urinary Tract Cancer Res., December 1, 2002; 62(23): 6796 - 6802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. J. Whitehall, C. V. A. Wynter, M. D. Walsh, L. A. Simms, D. Purdie, N. Pandeya, J. Young, S. J. Meltzer, B. A. Leggett, and J. R. Jass Morphological and Molecular Heterogeneity within Nonmicrosatellite Instability-High Colorectal Cancer Cancer Res., November 1, 2002; 62(21): 6011 - 6014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gazzoli, M. Loda, J. Garber, S. Syngal, and R. D. Kolodner A Hereditary Nonpolyposis Colorectal Carcinoma Case Associated with Hypermethylation of the MLH1 Gene in Normal Tissue and Loss of Heterozygosity of the Unmethylated Allele in the Resulting Microsatellite Instability-High Tumor Cancer Res., July 15, 2002; 62(14): 3925 - 3928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Gu, J. Wu, B.-B. Zhu, and G.-M. Li Deficiency of a novel mismatch repair activity in a bladder tumor cell line Nucleic Acids Res., July 1, 2002; 30(13): 2758 - 2763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Wahlberg, J. Schmeits, G. Thomas, M. Loda, J. Garber, S. Syngal, R. D. Kolodner, and E. Fox Evaluation of Microsatellite Instability and Immunohistochemistry for the Prediction of Germ-Line MSH2 and MLH1 Mutations in Hereditary Nonpolyposis Colon Cancer Families Cancer Res., June 1, 2002; 62(12): 3485 - 3492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Duval and R. Hamelin Mutations at Coding Repeat Sequences in Mismatch Repair-deficient Human Cancers: Toward a New Concept of Target Genes for Instability Cancer Res., May 1, 2002; 62(9): 2447 - 2454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Shannon, S Gnanasampanthan, J Beilby, and B Iacopetta A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability Gut, April 1, 2002; 50(4): 520 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Suzuki, T. Dai, I. Suzuki, Y. Dai, K. Yamashita, and M. Perucho Low Mutation Incidence in Polymorphic Noncoding Short Mononucleotide Repeats in Gastrointestinal Cancer of the Microsatellite Mutator Phenotype Pathway Cancer Res., April 1, 2002; 62(7): 1961 - 1965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J M D Wheeler, B F Warren, N J McC Mortensen, H C Kim, S C Biddolph, G Elia, N E Beck, G T Williams, N A Shepherd, A C Bateman, et al. An insight into the genetic pathway of adenocarcinoma of the small intestine Gut, February 1, 2002; 50(2): 218 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O.-O. Chan, J.-P. J. Issa, J. S. Morris, S. R. Hamilton, and A. Rashid Concordant CpG Island Methylation in Hyperplastic Polyposis Am. J. Pathol., February 1, 2002; 160(2): 529 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Baranovskaya, J. L. Soto, M. Perucho, and S. R. Malkhosyan Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype PNAS, December 6, 2001; (2001) 251234498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Esteller, M. F. Fraga, M. Guo, J. Garcia-Foncillas, I. Hedenfalk, A. K. Godwin, J. Trojan, C. Vaurs-Barriere, Y.-J. Bignon, S. Ramus, et al. DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis Hum. Mol. Genet., December 1, 2001; 10(26): 3001 - 3007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Young, L. A. Simms, K. G. Biden, C. Wynter, V. Whitehall, R. Karamatic, J. George, J. Goldblatt, I. Walpole, S.-A. Robin, et al. Features of Colorectal Cancers with High-Level Microsatellite Instability Occurring in Familial and Sporadic Settings : Parallel Pathways of Tumorigenesis Am. J. Pathol., December 1, 2001; 159(6): 2107 - 2116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hinoi, M. Tani, P. C. Lucas, K. Caca, R. L. Dunn, E. Macri¶, M. Loda¶, H. D. Appelman, K. R. Cho, and E. R. Fearon Loss of CDX2 Expression and Microsatellite Instability Are Prominent Features of Large Cell Minimally Differentiated Carcinomas of the Colon Am. J. Pathol., December 1, 2001; 159(6): 2239 - 2248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Raedle, J. Trojan, A. Brieger, N. Weber, D. Schafer, G. Plotz, E. Staib-Sebler, S. Kriener, M. Lorenz, and S. Zeuzem Bethesda Guidelines: Relation to Microsatellite Instability and MLH1 Promoter Methylation in Patients with Colorectal Cancer Ann Intern Med, October 16, 2001; 135(8_Part_1): 566 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nakagawa, G. J. Nuovo, E. E. Zervos, E. W. Martin Jr., R. Salovaara, L. A. Aaltonen, and A. de la Chapelle Age-related Hypermethylation of the 5' Region of MLH1 in Normal Colonic Mucosa Is Associated with Microsatellite-unstable Colorectal Cancer Development Cancer Res., October 1, 2001; 61(19): 6991 - 6995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Shrubsole, F. Jin, Q. Dai, X.-O. Shu, J. D. Potter, J. R. Hebert, Y.-T. Gao, and W. Zheng Dietary Folate Intake and Breast Cancer Risk: Results from the Shanghai Breast Cancer Study Cancer Res., October 1, 2001; 61(19): 7136 - 7141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Wu, D. Shibata, M. C. Yu, M.-Y. Lai, and R. K. Ross Dietary heterocyclic amines and microsatellite instability in colon adenocarcinomas Carcinogenesis, October 1, 2001; 22(10): 1681 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Hawkins and R. L. Ward Sporadic Colorectal Cancers With Microsatellite Instability and Their Possible Origin in Hyperplastic Polyps and Serrated Adenomas J Natl Cancer Inst, September 5, 2001; 93(17): 1307 - 1313. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
