Cancer Research Translational Cancer Medicine 2008: Cancer Clinical Trials and Personalized Medicine AACR Conference on Molecular Diagnostics - 2008
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Cell Growth & Differentiation
[Cancer Research 57, 842-845, March 1, 1997]
© 1997 American Association for Cancer Research
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Raffel, C.
Right arrow Articles by James, C. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Raffel, C.
Right arrow Articles by James, C. D.

Sporadic Medulloblastomas Contain PTCH Mutations1

Corey Raffel2, Robert B. Jenkins, Lori Frederick, Deanne Hebrink, Benjamin Alderete, Daniel W. Fults and C. David James

Departments of Neurosurgery [C. R.], Laboratory Medicine and Pathology [R. B. J., L. F., D. H., B. A., C. D. J.], Mayo Clinic and Foundation, Rochester, Minnesota 55905, and University of Utah Health Sciences Center, Salt Lake City, Utah 84132 [D. W. F.]

Nevoid basal cell carcinoma syndrome (NBCCS), or Gorlin's syndrome, is an autosomal dominant disorder that predisposes to developmental defects and various forms of cancer. PTCH was recently proposed as a candidate gene for NBCCS due to its frequent mutation in basal cell carcinomas, the cancer most often associated with this syndrome. Another NBCCS-associated cancer is medulloblastoma, a common central nervous system tumor in children. Most medulloblastomas, however, occur without indication of an inherited predisposition. We have examined 24 sporadic medulloblastomas for loss of heterozygosity (LOH) at loci flanking as well as within PTCH. In cases with LOH, single-strand conformational polymorphism and sequencing analysis were performed to determine the status of the remaining PTCH allele. Microsatellite analysis indicated LOH of PTCH in 5 of 24 tumors, and in three of these cases a mutation of the remaining allele was identified. Two of the mutations were duplication insertions, and the third consisted of a single base deletion. It is interesting that all three mutations occur in exon 17 of the PTCH gene. These data suggest that inactivation of PTCH function is involved in the development of at least a subset of sporadic medulloblastomas.

1 This work was supported by National Cancer Institute Grants CA55728 and CA50905.

2 To whom requests for reprints should be addressed, at Department of Neurosurgery, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905. Phone: (507) 284-3514; Fax: (507) 284-5206; E-mail: raffel.corey@mayo.edu.

Received 12/ 5/96. Accepted 1/17/97.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
J. Huang, M. A. Grotzer, T. Watanabe, E. Hewer, T. Pietsch, S. Rutkowski, and H. Ohgaki
Mutations in the Nijmegen Breakage Syndrome Gene in Medulloblastomas
Clin. Cancer Res., July 1, 2008; 14(13): 4053 - 4058.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Tada, F. Kanai, Y. Tanaka, K. Tateishi, M. Ohta, Y. Asaoka, M. Seto, R. Muroyama, K. Fukai, F. Imazeki, et al.
Down-Regulation of Hedgehog-Interacting Protein through Genetic and Epigenetic Alterations in Human Hepatocellular Carcinoma
Clin. Cancer Res., June 15, 2008; 14(12): 3768 - 3776.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
X. Fan and C. G. Eberhart
Medulloblastoma Stem Cells
J. Clin. Oncol., June 10, 2008; 26(17): 2821 - 2827.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. B. Dirks
Brain Tumor Stem Cells: Bringing Order to the Chaos of Brain Cancer
J. Clin. Oncol., June 10, 2008; 26(17): 2916 - 2924.
[Abstract] [Full Text] [PDF]

Home page
 J. Dent. Res.Home page
L.-S. Sun, X.-F. Li, and T.-J. Li
PTCH1 and SMO Gene Alterations in Keratocystic Odontogenic Tumors
J. Dent. Res., June 1, 2008; 87(6): 575 - 579.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. A. Hatton, E. H. Villavicencio, K. D. Tsuchiya, J. I. Pritchard, S. Ditzler, B. Pullar, S. Hansen, S. E. Knoblaugh, D. Lee, C. G. Eberhart, et al.
The Smo/Smo Model: Hedgehog-Induced Medulloblastoma with 90% Incidence and Leptomeningeal Spread
Cancer Res., March 15, 2008; 68(6): 1768 - 1776.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
D. Hambardzumyan, O. J. Becher, M. K. Rosenblum, P. P. Pandolfi, K. Manova-Todorova, and E. C. Holland
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
Genes & Dev., February 15, 2008; 22(4): 436 - 448.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
G. R. van den Brink
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
Physiol Rev, October 1, 2007; 87(4): 1343 - 1375.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
S. Farioli-Vecchioli, M. Tanori, L. Micheli, M. Mancuso, L. Leonardi, A. Saran, M. T. Ciotti, E. Ferretti, A. Gulino, S. Pazzaglia, et al.
Inhibition of medulloblastoma tumorigenesis by the antiproliferative and pro-differentiative gene PC3
FASEB J, July 1, 2007; 21(9): 2215 - 2225.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Sasai, J. T. Romer, H. Kimura, D. E. Eberhart, D. S. Rice, and T. Curran
Medulloblastomas Derived from Cxcr6 Mutant Mice Respond to Treatment with a Smoothened Inhibitor
Cancer Res., April 15, 2007; 67(8): 3871 - 3877.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. E. Bar, A. Chaudhry, M. H. Farah, and C. G. Eberhart
Hedgehog Signaling Promotes Medulloblastoma Survival via BclII
Am. J. Pathol., January 1, 2007; 170(1): 347 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Evangelista, H. Tian, and F. J. de Sauvage
The hedgehog signaling pathway in cancer.
Clin. Cancer Res., October 15, 2006; 12(20): 5924 - 5928.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Iacovelli, A. Arcella, G. Battaglia, S. Pazzaglia, E. Aronica, P. Spinsanti, A. Caruso, E. De Smaele, A. Saran, A. Gulino, et al.
Pharmacological Activation of mGlu4 Metabotropic Glutamate Receptors Inhibits the Growth of Medulloblastomas.
J. Neurosci., August 9, 2006; 26(32): 8388 - 8397.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Fan, W. Matsui, L. Khaki, D. Stearns, J. Chun, Y.-M. Li, and C. G. Eberhart
Notch Pathway Inhibition Depletes Stem-like Cells and Blocks Engraftment in Embryonal Brain Tumors.
Cancer Res., August 1, 2006; 66(15): 7445 - 7452.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Huang, J. He, X. Zhang, Y. Bian, L. Yang, G. Xie, K. Zhang, W. Tang, A. A. Stelter, Q. Wang, et al.
Activation of the hedgehog pathway in human hepatocellular carcinomas
Carcinogenesis, July 1, 2006; 27(7): 1334 - 1340.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. B. Corcoran and M. P. Scott
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
PNAS, May 30, 2006; 103(22): 8408 - 8413.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. Hartmann, B. Digon-Sontgerath, A. Koch, A. Waha, E. Endl, I. Dani, D. Denkhaus, C. G. Goodyer, N. Sorensen, O. D. Wiestler, et al.
Phosphatidylinositol 3'-Kinase/AKT Signaling Is Activated in Medulloblastoma Cell Proliferation and Is Associated with Reduced Expression of PTEN.
Clin. Cancer Res., May 15, 2006; 12(10): 3019 - 3027.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Sasai, J. T. Romer, Y. Lee, D. Finkelstein, C. Fuller, P. J. McKinnon, and T. Curran
Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies.
Cancer Res., April 15, 2006; 66(8): 4215 - 4222.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. R. Browd, A. M. Kenney, O. N. Gottfried, J. W. Yoon, D. Walterhouse, C. A. Pedone, and D. W. Fults
N-myc Can Substitute for Insulin-Like Growth Factor Signaling in a Mouse Model of Sonic Hedgehog-Induced Medulloblastoma.
Cancer Res., March 1, 2006; 66(5): 2666 - 2672.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Pan, M. Pellarin, E. Holmes, I. Smirnov, A. Misra, C. G. Eberhart, P. C. Burger, J. A. Biegel, and B. G. Feuerstein
Isochromosome 17q Is a Negative Prognostic Factor in Poor-Risk Childhood Medulloblastoma Patients
Clin. Cancer Res., July 1, 2005; 11(13): 4733 - 4740.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Romer and T. Curran
Targeting Medulloblastoma: Small-Molecule Inhibitors of the Sonic Hedgehog Pathway as Potential Cancer Therapeutics
Cancer Res., June 15, 2005; 65(12): 4975 - 4978.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
T. G. Oliver, T. A. Read, J. D. Kessler, A. Mehmeti, J. F. Wells, T. T. T. Huynh, S. M. Lin, and R. J. Wechsler-Reya
Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma
Development, May 15, 2005; 132(10): 2425 - 2439.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
W. Hartmann, A. Koch, H. Brune, A. Waha, U. Schuller, I. Dani, D. Denkhaus, W. Langmann, U. Bode, O. D. Wiestler, et al.
Insulin-Like Growth Factor II Is Involved in the Proliferation Control of Medulloblastoma and Its Cerebellar Precursor Cells
Am. J. Pathol., April 1, 2005; 166(4): 1153 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Boon, C. G. Eberhart, and G. J. Riggins
Genomic Amplification of Orthodenticle Homologue 2 in Medulloblastomas
Cancer Res., February 1, 2005; 65(3): 703 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Sanchez, A. M. Hernandez, B. Stecca, A. J. Kahler, A. M. DeGueme, A. Barrett, M. Beyna, M. W. Datta, S. Datta, and A. Ruiz i Altaba
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
PNAS, August 24, 2004; 101(34): 12561 - 12566.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. M. Lamont, C. S. McManamy, A. D. Pearson, S. C. Clifford, and D. W. Ellison
Combined Histopathological and Molecular Cytogenetic Stratification of Medulloblastoma Patients
Clin. Cancer Res., August 15, 2004; 10(16): 5482 - 5493.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. Fan, C. V. Pepicelli, C. C. Dibble, W. Catbagan, J. L. Zarycki, R. Laciak, J. Gipp, A. Shaw, M. L. G. Lamm, A. Munoz, et al.
Hedgehog Signaling Promotes Prostate Xenograft Tumor Growth
Endocrinology, August 1, 2004; 145(8): 3961 - 3970.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. S. Collier, K. Suyama, J. H. Anderson, and M. P. Scott
Drosophila Costal1 Mutations Are Alleles of Protein Kinase A That Modulate Hedgehog Signaling
Genetics, June 1, 2004; 167(2): 783 - 796.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Dahlen, C. D. M. Fletcher, F. Mertens, J. A. Fletcher, A. R. Perez-Atayde, M. J. Hicks, M. Debiec-Rychter, R. Sciot, J. Wejde, R. Wedin, et al.
Activation of the GLI Oncogene through Fusion with the {beta}-Actin Gene (ACTB) in a Group of Distinctive Pericytic Neoplasms: Pericytoma with t(7;12)
Am. J. Pathol., May 1, 2004; 164(5): 1645 - 1653.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Lee, H. L. Miller, P. Jensen, R. Hernan, M. Connelly, C. Wetmore, F. Zindy, M. F. Roussel, T. Curran, R. J. Gilbertson, et al.
A Molecular Fingerprint for Medulloblastoma
Cancer Res., September 1, 2003; 63(17): 5428 - 5437.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. G. Oliver, L. L. Grasfeder, A. L. Carroll, C. Kaiser, C. L. Gillingham, S. M. Lin, R. Wickramasinghe, M. P. Scott, and R. J. Wechsler-Reya
Transcriptional profiling of the Sonic hedgehog response: A critical role for N-myc in proliferation of neuronal precursors
PNAS, June 10, 2003; 100(12): 7331 - 7336.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. A. Williams, O. M. Guicherit, B. I. Zaharian, Y. Xu, L. Chai, H. Wichterle, C. Kon, C. Gatchalian, J. A. Porter, L. L. Rubin, et al.
Identification of a small molecule inhibitor of the hedgehog signaling pathway: Effects on basal cell carcinoma-like lesions
PNAS, April 15, 2003; 100(8): 4616 - 4621.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
T. J. MacDonald, B. R. Rood, M. R. Santi, G. Vezina, K. Bingaman, P. H. Cogen, and R. J. Packer
Advances in the Diagnosis, Molecular Genetics, and Treatment of Pediatric Embryonal CNS Tumors
Oncologist, April 1, 2003; 8(2): 174 - 186.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Ishibashi and A. P. McMahon
A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo
Development, March 12, 2003; 129(20): 4807 - 4819.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Z. Hu, J. M. Bonifas, G. Aragon, L. Kopelovich, Y. Liang, S. Ohta, M. A. Israel, D. R. Bickers, M. Aszterbaum, and E. H. Epstein Jr.
Evidence for Lack of Enhanced Hedgehog Target Gene Expression in Common Extracutaneous Tumors
Cancer Res., March 1, 2003; 63(5): 923 - 928.
[Abstract] [Full Text] [PDF]

Home page
 Recent Prog Horm ResHome page
R. J. Wechsler-Reya
Analysis of Gene Expression in the Normal and Malignant Cerebellum
Recent Prog. Horm. Res., January 1, 2003; 58(1): 227 - 248.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
W.-M. Tong, H. Ohgaki, H. Huang, C. Granier, P. Kleihues, and Z.-Q. Wang
Null Mutation of DNA Strand Break-Binding Molecule Poly(ADP-ribose) Polymerase Causes Medulloblastomas in p53-/- Mice
Am. J. Pathol., January 1, 2003; 162(1): 343 - 352.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. L. Weiner, R. Bakst, M. S. Hurlbert, J. Ruggiero, E. Ahn, W. S. Lee, D. Stephen, D. Zagzag, A. L. Joyner, and D. H. Turnbull
Induction of Medulloblastomas in Mice by Sonic Hedgehog, Independent of Gli1
Cancer Res., November 15, 2002; 62(22): 6385 - 6389.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. E. Lusher, J. C. Lindsey, F. Latif, A. D. J. Pearson, D. W. Ellison, and S. C. Clifford
Biallelic Epigenetic Inactivation of the RASSF1A Tumor Suppressor Gene in Medulloblastoma Development
Cancer Res., October 15, 2002; 62(20): 5906 - 5911.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. C. Bailey, L. Milenkovic, M. P. Scott, J. F. Collawn, and R. L. Johnson
Several PATCHED1 Missense Mutations Display Activity in patched1-Deficient Fibroblasts
J. Biol. Chem., September 6, 2002; 277(37): 33632 - 33640.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. J. Solecki, M. Gromeier, S. Mueller, G. Bernhardt, and E. Wimmer
Expression of the Human Poliovirus Receptor/CD155 Gene Is Activated by Sonic Hedgehog
J. Biol. Chem., July 5, 2002; 277(28): 25697 - 25702.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. E. Nybakken, C. W. Turck, D. J. Robbins, and J. M. Bishop
Hedgehog-stimulated Phosphorylation of the Kinesin-related Protein Costal2 Is Mediated by the Serine/Threonine Kinase Fused
J. Biol. Chem., June 28, 2002; 277(27): 24638 - 24647.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
N. Dahmane, P. Sanchez, Y. Gitton, V. Palma, T. Sun, M. Beyna, H. Weiner, and A. Ruiz i Altaba
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
Development, December 15, 2001; 128(24): 5201 - 5212.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
H. Tsao
Genetics of Nonmelanoma Skin Cancer
Arch Dermatol, November 1, 2001; 137(11): 1486 - 1492.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. R. Lu, J. K. Park, E. Noll, J. A. Chan, J. Alberta, D. Yuk, M. G. Alzamora, D. N. Louis, C. D. Stiles, D. H. Rowitch, et al.
Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors
PNAS, August 23, 2001; (2001) 181340798.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Xie, M. Aszterbaum, X. Zhang, J. M. Bonifas, C. Zachary, E. Epstein, and F. McCormick
A role of PDGFRalpha in basal cell carcinoma proliferation
PNAS, July 31, 2001; 98(16): 9255 - 9259.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
E. A. Maher, F. B. Furnari, R. M. Bachoo, D. H. Rowitch, D. N. Louis, W. K. Cavenee, and R. A. DePinho
Malignant glioma: genetics and biology of a grave matter
Genes & Dev., June 1, 2001; 15(11): 1311 - 1333.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Wetmore, D. E. Eberhart, and T. Curran
Loss of p53 but not ARF Accelerates Medulloblastoma in Mice Heterozygous for patched
Cancer Res., January 1, 2001; 61(2): 513 - 516.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
A. M. Kenney and D. H. Rowitch
Sonic hedgehog Promotes G1 Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors
Mol. Cell. Biol., December 1, 2000; 20(23): 9055 - 9067.
[Abstract] [Full Text]

Home page
 Clin. Cancer Res.Home page
J. A. Biegel, B. Fogelgren, J.-Y. Zhou, C. D. James, A. J. Janss, J. C. Allen, D. Zagzag, C. Raffel, and L. B. Rorke
Mutations of the INI1 Rhabdoid Tumor Suppressor Gene in Medulloblastomas and Primitive Neuroectodermal Tumors of the Central Nervous System
Clin. Cancer Res., July 1, 2000; 6(7): 2759 - 2763.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
C. Wetmore, D. E. Eberhart, and T. Curran
The Normal patched Allele Is Expressed in Medulloblastomas from Mice with Heterozygous Germ-Line Mutation of patched
Cancer Res., April 1, 2000; 60(8): 2239 - 2246.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
H. Huang, B. M. Mahler-Araujo, A. Sankila, L. Chimelli, Y. Yonekawa, P. Kleihues, and H. Ohgaki
APC Mutations in Sporadic Medulloblastomas
Am. J. Pathol., February 1, 2000; 156(2): 433 - 437.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. H. Rowitch, B. St.-Jacques, S. M. K. Lee, J. D. Flax, E. Y. Snyder, and A. P. McMahon
Sonic hedgehog Regulates Proliferation and Inhibits Differentiation of CNS Precursor Cells
J. Neurosci., October 15, 1999; 19(20): 8954 - 8965.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
B. St-Jacques, M. Hammerschmidt, and A. P. McMahon
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
Genes & Dev., August 15, 1999; 13(16): 2072 - 2086.
[Abstract] [Full Text]

Home page
 J Child NeurolHome page
A. M. Adesma
Topical Review: Molecular Heterogeneity in Medulloblastoma With Implications for Differing Tumor Biology
J Child Neurol, July 1, 1999; 14(7): 411 - 417.
[Abstract] [PDF]

Home page
 Neuro OncolHome page
J. A. Biegel
Cytogenetics and molecular genetics of childhood brain tumors
Neuro-oncol, April 1, 1999; 1(2): 139 - 151.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
J. R. Hill, N. Kuriyama, H. Kuriyama, and M. A. Israel
Molecular Genetics of Brain Tumors
Arch Neurol, April 1, 1999; 56(4): 439 - 441.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
L. V. Goodrich, L. Milenkovi, K. M. Higgins, and M. P. Scott
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Science, August 22, 1997; 277(5329): 1109 - 1113.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. R. Lu, J. K. Park, E. Noll, J. A. Chan, J. Alberta, D. Yuk, M. G. Alzamora, D. N. Louis, C. D. Stiles, D. H. Rowitch, et al.
Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors
PNAS, September 11, 2001; 98(19): 10851 - 10856.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal