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Haplotype Analysis Defines a Minimal Interval for the Multiple Endocrine Neoplasia Type 1 (MEN1) Gene

Laboratory of Pathology, National Cancer Institute [L.V.D., M.R.E-B., E.M.D., I.A.L., Z.Z., L.A.L.], Laboratory of Gene Transfer, National Center for Human Genome Research [P.M., S.C.G., S-E.O., F.S.C., S.C.C.], and Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases [M.K., S.A., A.L.B., A.M.S., S.J.M.], NIH, Bethesda, Maryland, 20892

Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome characterized by development of multiple endocrine tumors in affected individuals. The gene responsible for the disease has been mapped to chromosome 11q13 by linkage analysis, but the gene itself has not yet been identified. We allelotyped 33 affected individuals from an extensive MEN1 kindred using eight polymorphic markers located on chromosome 11q13, including two new markers (D11S4907 and D11S4908) that we derived and mapped to the SEA-D11S913 region. Analysis of affected individuals revealed two separate recombination events, providing new centromeric and telomeric boundaries for the MEN1 gene. The present data indicate the MEN1 gene is located between markers D11S1883 and D11S4907, an approximate 2 Mb region on chromsome 11q13.

¹ To whom requests for reprints should be addressed, at Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A33, 9000 Rockville Pike, Bethesda, MD 20892.

Received 11/26/96. Accepted 1/17/97.

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