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[Cancer Research 57, 1063-1065, March 15, 1997]
© 1997 American Association for Cancer Research
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A Polymorphism in the CYP17 Gene Increases the Risk of Breast Cancer1

Heather Spencer Feigelson, Gerhard A. Coetzee, Laurence N. Kolonel, Ronald K. Ross and Brian E. Henderson2

Departments of Preventive Medicine [H. S. F., R. K. R., B. E. H.] and Urology [G. A. C.], University of Southern California School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA 90033-0800, and Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii 96813 [L. N. K.]

We conducted a case-control study to determine whether a polymorphism in the CYP17 gene was associated with risk of breast cancer. We found an increased risk of advanced breast cancer in women carrying an A2 allele. The odds ratio was 2.5 [95% confidence interval (CI), 1.07–5.94] for regional or metastatic disease. Among controls, the A1/A1 genotype was associated with a later age at menarche. The reduced risk of breast cancer associated with a later age of menarche was largely limited to A1/A1 women: odds ratio, 0.47 (CI, 0.22–0.98) for breast cancer and later age at menarche among A1 homozygotes compared with 0.80 (CI, 0.51–1.27) for A1/A2 and A2/A2 genotypes. These findings suggest that the CYP17 genotype may be a biomarker for the onset of ovulation and advanced breast cancer risk.

1 This work was supported by State of California Grants 11B-0084 and 2FB-0212 and National Cancer Institute Grant CA-54281.

2 To whom requests for reprints should be addressed, at Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, MS 44, Los Angeles, CA 90033-0800. Phone: (213) 764-0419; Fax: (213) 764-0127.

Received 12/ 6/96. Accepted 2/ 1/97.




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