This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Tan, P. Articles by Loda, M. Search for Related Content PubMed PubMed Citation Articles by Tan, P. Articles by Loda, M.

The Cell Cycle Inhibitor p27 Is an Independent Prognostic Marker in Small (T_1a,b) Invasive Breast Carcinomas

Departments of Pathology [P. T., M. W., B. Cu., C. M-G., M. L.] and Surgery [B. Ca.], Beth Israel Deaconess Medical Center, West Campus, Harvard Medical School, Boston, Massachusetts 02215; Mitotix, Inc., Cambridge, Massachusetts 02139 [P. W.]; Boston Biostatistics Research Foundation, Inc., Framingham, Massachusetts 01702 [P. L.]; European Institute of Oncology, Via Ripamonti 435, Milan 20141, Italy [G. D.]; and Department of Pathology and Kaplan Comprehensive Cancer Center, New York University Medical Center, New York, New York 10016 [M. P.]

Breast carcinomas 1 cm in size (T_1a,b) are being detected more frequently as a result of screening. Because traditional prognostic parameters are either lacking (tumor size) or rare (nodal metastases), a marker(s) is needed to identify the subset of patients who could benefit from adjuvant therapy. A retrospective series of 202 patients with stage T_1a,b invasive breast carcinomas was evaluated. The clinicopathological features (age, histological grade, extensive in situ carcinoma, hormone receptor status, and nodal metastasis) as well as microvessel density and the expression of c-erb-B2, p53, MIB-1/Ki-67, and cdc25B were assessed. In addition, expression of the cell cycle inhibitor p27 was evaluated.

Nineteen patients (18% of patients who had axillary dissection) had locoregional lymph node metastases. Forty-two % of them died of disease (median survival, 112 months), whereas mortality was 11% in node-negative patients (median survival, 168 months; P = 0.0055). Patients with low p27 expression had a median survival of 139 months (17% mortality) versus 174 months (9% mortality) in the group with high p27 expression (P = 0.0233). Lack of p27 was associated with poor prognosis when node-positive patients were excluded (P = 0.0252). Nodal status and low p27 were found to be the only independent prognostic parameters by both univariate and multivariate analysis, with relative risks of dying of disease of 4.9 (P = 0.001) and 3.4 (P = 0.0306), respectively.

Assessment of p27, which yields prognostic information in node-negative patients, could be useful to identify patients with small, invasive breast carcinomas who might benefit from adjuvant therapy.

¹ Supported in part by NIH grant CA 66229-02.

² To whom requests for reprints should be addressed, at Department of Pathology, Laboratory of Molecular Pathology, Beth Israel Deaconess Medical Center, West Campus, One Deaconess Road, Boston, MA 02215. Phone: (617) 632-0997; Fax: (617) 632-0989; E-mail: mloda@west.bidmc.harvard.edu.

Received 12/23/96. Accepted 2/14/97.

This article has been cited by other articles:

				M. Filipits, M. Rudas, H. Heinzl, R. Jakesz, E. Kubista, S. Lax, W. Schippinger, O. Dietze, R. Greil, W. Stiglbauer, et al. Low p27 Expression Predicts Early Relapse and Death in Postmenopausal Hormone Receptor-Positive Breast Cancer Patients Receiving Adjuvant Tamoxifen Therapy Clin. Cancer Res., September 15, 2009; 15(18): 5888 - 5894. [Abstract] [Full Text] [PDF]

				Y. Chen, N. Guggisberg, M. Jorda, A. Gonzalez-Angulo, B. Hennessy, G. B. Mills, C.-K. Tan, and J. M. Slingerland Combined Src and Aromatase Inhibition Impairs Human Breast Cancer Growth In vivo and Bypass Pathways Are Activated in AZD0530-Resistant Tumors Clin. Cancer Res., May 15, 2009; 15(10): 3396 - 3405. [Abstract] [Full Text] [PDF]

				H.-C. Huang, T.-D. Way, C.-L. Lin, and J.-K. Lin EGCG Stabilizes p27kip1 in E2-Stimulated MCF-7 Cells through Down-Regulation of the Skp2 Protein Endocrinology, December 1, 2008; 149(12): 5972 - 5983. [Abstract] [Full Text] [PDF]

				Z. Wang, B. W. Yu, K. W. Rahman, F. Ahmad, and F. H. Sarkar Induction of growth arrest and apoptosis in human breast cancer cells by 3,3-diindolylmethane is associated with induction and nuclear localization of p27kip Mol. Cancer Ther., February 1, 2008; 7(2): 341 - 349. [Abstract] [Full Text] [PDF]

				L. Westbrook, M. Manuvakhova, F. G. Kern, N. R. Estes II, H. N. Ramanathan, and J. V. Thottassery Cks1 Regulates cdk1 Expression: A Novel Role during Mitotic Entry in Breast Cancer Cells Cancer Res., December 1, 2007; 67(23): 11393 - 11401. [Abstract] [Full Text] [PDF]

				A. Besson, H. C. Hwang, S. Cicero, S. L. Donovan, M. Gurian-West, D. Johnson, B. E. Clurman, M. A. Dyer, and J. M. Roberts Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype Genes & Dev., July 15, 2007; 21(14): 1731 - 1746. [Abstract] [Full Text] [PDF]

				P. L. Porter, W. E. Barlow, I-T. Yeh, M. G. Lin, X. P. Yuan, E. Donato, G. W. Sledge, C. L. Shapiro, J. N. Ingle, C. M. Haskell, et al. p27Kip1 and Cyclin E Expression and Breast Cancer Survival After Treatment With Adjuvant Chemotherapy J Natl Cancer Inst, December 6, 2006; 98(23): 1723 - 1731. [Abstract] [Full Text] [PDF]

				E. Reinstein and A. Ciechanover Narrative review: protein degradation and human diseases: the ubiquitin connection. Ann Intern Med, November 7, 2006; 145(9): 676 - 684. [Abstract] [Full Text] [PDF]

				G. M. Callagy, P. D. Pharoah, S. E. Pinder, F. D. Hsu, T. O. Nielsen, J. Ragaz, I. O. Ellis, D. Huntsman, and C. Caldas Bcl-2 Is a Prognostic Marker in Breast Cancer Independently of the Nottingham Prognostic Index Clin. Cancer Res., April 15, 2006; 12(8): 2468 - 2475. [Abstract] [Full Text] [PDF]

				H. Sonoda, H. Inoue, K. Ogawa, T. Utsunomiya, T.-a. Masuda, and M. Mori Significance of Skp2 Expression in Primary Breast Cancer Clin. Cancer Res., February 15, 2006; 12(4): 1215 - 1220. [Abstract] [Full Text] [PDF]

				M. Colozza, E. Azambuja, F. Cardoso, C. Sotiriou, D. Larsimont, and M. J. Piccart Proliferative markers as prognostic and predictive tools in early breast cancer: where are we now? Ann. Onc., November 1, 2005; 16(11): 1723 - 1739. [Abstract] [Full Text] [PDF]

				S. Kotoshiba, T. Kamura, T. Hara, N. Ishida, and K. I. Nakayama Molecular Dissection of the Interaction between p27 and Kip1 Ubiquitylation-promoting Complex, the Ubiquitin Ligase That Regulates Proteolysis of p27 in G1 Phase J. Biol. Chem., May 6, 2005; 280(18): 17694 - 17700. [Abstract] [Full Text] [PDF]

				Y. Kudo, S. Kitajima, I. Ogawa, M. Kitagawa, M. Miyauchi, and T. Takata Small interfering RNA targeting of S phase kinase-interacting protein 2 inhibits cell growth of oral cancer cells by inhibiting p27 degradation Mol. Cancer Ther., March 1, 2005; 4(3): 471 - 476. [Abstract] [Full Text] [PDF]

				Y. Kotake, K. Nakayama, N. Ishida, and K. I. Nakayama Role of Serine 10 Phosphorylation in p27 Stabilization Revealed by Analysis of p27 Knock-in Mice Harboring a Serine 10 Mutation J. Biol. Chem., January 14, 2005; 280(2): 1095 - 1102. [Abstract] [Full Text] [PDF]

				D. R. Shaffer, A. Viale, R. Ishiwata, M. Leversha, S. Olgac, K. Manova, J. Satagopan, H. Scher, and A. Koff Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate PNAS, January 4, 2005; 102(1): 210 - 215. [Abstract] [Full Text] [PDF]

				Y. Dong, L. Sui, Y. Watanabe, F. Yamaguchi, N. Hatano, and M. Tokuda Prognostic Significance of Jab1 Expression in Laryngeal Squamous Cell Carcinomas Clin. Cancer Res., January 1, 2005; 11(1): 259 - 266. [Abstract] [Full Text] [PDF]

				L. K. Pierson-Mullany and C. A. Lange Phosphorylation of Progesterone Receptor Serine 400 Mediates Ligand-Independent Transcriptional Activity in Response to Activation of Cyclin-Dependent Protein Kinase 2 Mol. Cell. Biol., December 15, 2004; 24(24): 10542 - 10557. [Abstract] [Full Text] [PDF]

				S. Kitajima, Y. Kudo, I. Ogawa, T. Bashir, M. Kitagawa, M. Miyauchi, M. Pagano, and T. Takata Role of Cks1 Overexpression in Oral Squamous Cell Carcinomas: Cooperation with Skp2 in Promoting p27 Degradation Am. J. Pathol., December 1, 2004; 165(6): 2147 - 2155. [Abstract] [Full Text] [PDF]

				S. Lahav-Baratz, O. Ben-Izhak, E. Sabo, S. Ben-Eliezer, O. Lavie, D. Ishai, A. Ciechanover, and M. Dirnfeld Decreased level of the cell cycle regulator p27 and increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated endometrium Mol. Hum. Reprod., August 1, 2004; 10(8): 567 - 572. [Abstract] [Full Text] [PDF]

				Y. H. Min, J.-W. Cheong, M. H. Lee, J. Y. Kim, S. T. Lee, J. S. Hahn, and Y. W. Ko Elevated S-Phase Kinase-Associated Protein 2 Protein Expression in Acute Myelogenous Leukemia: Its Association with Constitutive Phosphorylation of Phosphatase and Tensin Homologue Protein and Poor Prognosis Clin. Cancer Res., August 1, 2004; 10(15): 5123 - 5130. [Abstract] [Full Text] [PDF]

				C. Osborne, P. Wilson, and D. Tripathy Oncogenes and Tumor Suppressor Genes in Breast Cancer: Potential Diagnostic and Therapeutic Applications Oncologist, July 1, 2004; 9(4): 361 - 377. [Abstract] [Full Text] [PDF]

				K. E. A. LaRue, M. Khalil, and J. P. Freyer Microenvironmental Regulation of Proliferation in Multicellular Spheroids Is Mediated through Differential Expression of Cyclin-Dependent Kinase Inhibitors Cancer Res., March 1, 2004; 64(5): 1621 - 1631. [Abstract] [Full Text] [PDF]

				J. J. Lucas, J. Domenico, and E. W. Gelfand Cyclin-Dependent Kinase 6 Inhibits Proliferation of Human Mammary Epithelial Cells Mol. Cancer Res., February 1, 2004; 2(2): 105 - 114. [Abstract] [Full Text] [PDF]

				M. A. Ghanem, T. H. Van der Kwast, M. K. Sudaryo, R. B. Mathoera, M. M. van den Heuvel, A.-A. M. Al-Doray, R. M. Nijman, and G. J. van Steenbrugge MIB-1 (KI-67) Proliferation Index and Cyclin-Dependent Kinase Inhibitor p27Kip1 Protein Expression in Nephroblastoma Clin. Cancer Res., January 15, 2004; 10(2): 591 - 597. [Abstract] [Full Text] [PDF]

				Z. Wang and M. J. Garabedian Modulation of Glucocorticoid Receptor Transcriptional Activation, Phosphorylation, and Growth Inhibition by p27Kip1 J. Biol. Chem., December 19, 2003; 278(51): 50897 - 50901. [Abstract] [Full Text] [PDF]

				A A Khan, P D Abel, K S Chaudhary, Z Gulzar, G W H Stamp, and E-N Lalani Inverse correlation between high level expression of cyclin E and proliferation index in transitional cell carcinoma of the bladder Mol. Pathol., December 1, 2003; 56(6): 353 - 361. [Abstract] [Full Text] [PDF]

				F. J. Esteva, A. A. Sahin, G. Z. Rassidakis, L. X. H. Yuan, T. L. Smith, Y. Yang, M. Z. Gilcrease, M. Cristofanilli, R. Nahta, L. Pusztai, et al. Jun Activation Domain Binding Protein 1 Expression Is Associated with Low p27Kip1Levels in Node-Negative Breast Cancer Clin. Cancer Res., November 15, 2003; 9(15): 5652 - 5659. [Abstract] [Full Text] [PDF]

				J. S. Foster, R. I. Fernando, N. Ishida, K. I. Nakayama, and J. Wimalasena Estrogens Down-regulate p27Kip1 in Breast Cancer Cells through Skp2 and through Nuclear Export Mediated by the ERK Pathway J. Biol. Chem., October 17, 2003; 278(42): 41355 - 41366. [Abstract] [Full Text] [PDF]

				G. Pohl, M. Rudas, O. Dietze, S. Lax, E. Markis, R. Pirker, C. C. Zielinski, H. Hausmaninger, E. Kubista, H. Samonigg, et al. High p27Kip1 Expression Predicts Superior Relapse-Free and Overall Survival for Premenopausal Women With Early-Stage Breast Cancer Receiving Adjuvant Treatment With Tamoxifen Plus Goserelin J. Clin. Oncol., October 1, 2003; 21(19): 3594 - 3600. [Abstract] [Full Text] [PDF]

				S. R. Payne and C. J. Kemp p27 Kip1 (Cdkn1b)-Deficient Mice Are Susceptible to Chemical Carcinogenesis and May Be a Useful Model for Carcinogen Screening Toxicol Pathol, June 1, 2003; 31(4): 355 - 363. [Abstract] [PDF]

				W. Reed, B. Sandstad, R. Holm, and J. M. Nesland The Prognostic Impact of Hormone Receptors and c-erbB-2 in Pregnancy-Associated Breast Cancer and Their Correlation with BRCAI and Cell Cycle Modulators International Journal of Surgical Pathology, April 1, 2003; 11(2): 65 - 74. [Abstract] [PDF]

				T.-a. Masuda, H. Inoue, H. Sonoda, S. Mine, Y. Yoshikawa, K. Nakayama, K.-I. Nakayama, and M. Mori Clinical and Biological Significance of S-Phase Kinase-associated Protein 2 (Skp2) Gene Expression in Gastric Carcinoma: Modulation of Malignant Phenotype by Skp2 Overexpression, Possibly via p27 Proteolysis Cancer Res., July 1, 2002; 62(13): 3819 - 3825. [Abstract] [Full Text] [PDF]

				P. P. Claudio, A. Zamparelli, F. U. Garcia, L. Claudio, G. Ammirati, A. Farina, A. Bovicelli, G. Russo, G. G. Giordano, D. E. McGinnis, et al. Expression of Cell-Cycle-regulated Proteins pRb2/p130, p107, p27kip1, p53, mdm-2, and Ki-67 (MIB-1) in Prostatic Gland Adenocarcinoma Clin. Cancer Res., June 1, 2002; 8(6): 1808 - 1815. [Abstract] [Full Text] [PDF]

				C. Van Poznak, L. Tan, K. S. Panageas, C. D. Arroyo, C. Hudis, L. Norton, and A. D. Seidman Assessment of Molecular Markers of Clinical Sensitivity to Single-Agent Taxane Therapy for Metastatic Breast Cancer J. Clin. Oncol., May 1, 2002; 20(9): 2319 - 2326. [Abstract] [Full Text] [PDF]

				R. S. Muraoka, A. E. G. Lenferink, B. Law, E. Hamilton, D. M. Brantley, L. R. Roebuck, and C. L. Arteaga ErbB2/Neu-Induced, Cyclin D1-Dependent Transformation Is Accelerated in p27-Haploinsufficient Mammary Epithelial Cells but Impaired in p27-Null Cells Mol. Cell. Biol., April 1, 2002; 22(7): 2204 - 2219. [Abstract] [Full Text] [PDF]

				M. Fiorentino, A. Altimari, A. D'Errico, E. Gabusi, P. Chieco, M. Masetti, and W. F. Grigioni Low p27 Expression Is an Independent Predictor of Survival for Patients with Either Hilar or Peripheral Intrahepatic Cholangiocarcinoma Clin. Cancer Res., December 1, 2001; 7(12): 3994 - 3999. [Abstract] [Full Text] [PDF]

				J. Lapointe and C. Labrie Role of the Cyclin-Dependent Kinase Inhibitor p27Kip1 in Androgen-Induced Inhibition of CAMA-1 Breast Cancer Cell Proliferation Endocrinology, October 1, 2001; 142(10): 4331 - 4338. [Abstract] [Full Text] [PDF]

				R. S. Muraoka, A. E.G. Lenferink, J. Simpson, D. M. Brantley, L. R. Roebuck, F. M. Yakes, and C. L. Arteaga Cyclin-Dependent Kinase Inhibitor P27Kip1 Is Required for Mouse Mammary Gland Morphogenesis and Function J. Cell Biol., May 28, 2001; 153(5): 917 - 932. [Abstract] [Full Text] [PDF]

				M. Gstaiger, R. Jordan, M. Lim, C. Catzavelos, J. Mestan, J. Slingerland, and W. Krek Skp2 is oncogenic and overexpressed in human cancers PNAS, April 12, 2001; (2001) 81474898. [Abstract] [Full Text]

				B. Fisher, J. Dignam, E. Tan-Chiu, S. Anderson, E. R. Fisher, J. L. Wittliff, and N. Wolmark Prognosis and Treatment of Patients With Breast Tumors of One Centimeter or Less and Negative Axillary Lymph Nodes J Natl Cancer Inst, January 17, 2001; 93(2): 112 - 120. [Abstract] [Full Text] [PDF]

				P. O. Chappuis, L. Kapusta, L. R. Begin, N. Wong, J.-S. Brunet, S. A. Narod, J. Slingerland, and W. D. Foulkes Germline BRCA1/2 Mutations and p27Kip1 Protein Levels Independently Predict Outcome After Breast Cancer J. Clin. Oncol., December 15, 2000; 18(24): 4045 - 4052. [Abstract] [Full Text] [PDF]

				C. Abate-Shen and M. M. Shen Molecular genetics of prostate cancer Genes & Dev., October 1, 2000; 14(19): 2410 - 2434. [Full Text]

				M. Fiorentino, A. Altimari, A. D’Errico, B. Cukor, C. Barozzi, M. Loda, and W. F. Grigioni Acquired Expression of p27 Is a Favorable Prognostic Indicator in Patients with Hepatocellular Carcinoma Clin. Cancer Res., October 1, 2000; 6(10): 3966 - 3972. [Abstract] [Full Text]

				F. Hommura, H. Dosaka-Akita, T. Mishina, M. Nishi, T. Kojima, H. Hiroumi, S. Ogura, M. Shimizu, H. Katoh, and Y. Kawakami Prognostic Significance of p27KIP1 Protein and Ki-67 Growth Fraction in Non-small Cell Lung Cancers Clin. Cancer Res., October 1, 2000; 6(10): 4073 - 4081. [Abstract] [Full Text]

				A. M. Oliveira, A. G. Nascimento, S. H. Okuno, and R. V. Lloyd p27kip1 Protein Expression Correlates With Survival in Myxoid and Round-Cell Liposarcoma J. Clin. Oncol., August 15, 2000; 18(15): 2888 - 2893. [Abstract] [Full Text] [PDF]

				P N Nelson, G M Reynolds, E E Waldron, E Ward, K Giannopoulos, and P G Murray Demystified ...: Monoclonal antibodies Mol. Pathol., June 1, 2000; 53(3): 111 - 117. [Abstract] [Full Text]

				R. Chiarle, L. M. Budel, J. Skolnik, G. Frizzera, M. Chilosi, A. Corato, G. Pizzolo, J. Magidson, A. Montagnoli, M. Pagano, et al. Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma Blood, January 15, 2000; 95(2): 619 - 626. [Abstract] [Full Text] [PDF]

				K. Ogawa, N. Kimoto, M. Asamoto, M. Nakanishi, S. Takahashi, and T. Shirai Aberrant expression of p27Kip1 is associated with malignant transformation of the rat urinary bladder epithelium Carcinogenesis, January 1, 2000; 21(1): 117 - 121. [Abstract] [Full Text] [PDF]

				M. Manzotti, P. Dell’Orto, P. Maisonneuve, M. Fornaro, L. R. Languino, and G. Viale Down-Regulation of {beta}1C Integrin in Breast Carcinomas Correlates with High Proliferative Fraction, High Histological Grade, and Larger Size Am. J. Pathol., January 1, 2000; 156(1): 169 - 174. [Abstract] [Full Text] [PDF]

				C. C. R. Lee, T. Ichihara, S. Yamamoto, H. Wanibuchi, K. Sugimura, S. Wada, T. Kishimoto, and S. Fukushima Reduced expression of the CDK inhibitor p27KIP1 in rat two-stage bladder carcinogenesis and its association with expression profiles of p21WAF1/Cip1 and p53 Carcinogenesis, September 1, 1999; 20(9): 1697 - 1708. [Abstract] [Full Text] [PDF]

				B. Carlson, T. Lahusen, S. Singh, A. Loaiza-Perez, P. J. Worland, R. Pestell, C. Albanese, E. A. Sausville, and A. M. Senderowicz Down-Regulation of Cyclin D1 by Transcriptional Repression in MCF-7 Human Breast Carcinoma Cells Induced by Flavopiridol Cancer Res., September 1, 1999; 59(18): 4634 - 4641. [Abstract] [Full Text] [PDF]

				J. D. heng, B. A. Werness, J. S. Babb, and N. J. Meropol Paradoxical Correlations of Cyclin-dependent Kinase Inhibitors p21waf1/cip1 and p27kip1 in Metastatic Colorectal Carcinoma Clin. Cancer Res., May 1, 1999; 5(5): 1057 - 1062. [Abstract] [Full Text] [PDF]

				P. L. M. Dahia and A. B. Grossman The Molecular Pathogenesis of Corticotroph Tumors Endocr. Rev., April 1, 1999; 20(2): 136 - 155. [Abstract] [Full Text]

				S. Mizumatsu, T. Tamiya, Y. Ono, T. Abe, K. Matsumoto, T. Furuta, and T. Ohmoto Expression of Cell Cycle Regulator p27Kip1 Is Correlated with Survival of Patients with Astrocytoma Clin. Cancer Res., March 1, 1999; 5(3): 551 - 557. [Abstract] [Full Text] [PDF]

				C. Catzavelos, M.-S. Tsao, G. DeBoer, N. Bhattacharya, F. A. Shepherd, and J. M. Slingerland Reduced Expression of the Cell Cycle Inhibitor p27Kip1 in Non-Small Cell Lung Carcinoma: A Prognostic Factor Independent of Ras Cancer Res., February 1, 1999; 59(3): 684 - 688. [Abstract] [Full Text] [PDF]

				R. V. Lloyd, L. A. Erickson, L. Jin, E. Kulig, X. Qian, J. C. Cheville, and B. W. Scheithauer p27kip1: A Multifunctional Cyclin-Dependent Kinase Inhibitor with Prognostic Significance in Human Cancers Am. J. Pathol., February 1, 1999; 154(2): 313 - 323. [Abstract] [Full Text] [PDF]

				E. W. Newcomb, M. Sosnow, R. I. Demopoulos, A. Zeleniuch-Jacquotte, J. Sorich, and J. L. Speyer Expression of the Cell Cycle Inhibitor p27KIP1 Is a New Prognostic Marker Associated with Survival in Epithelial Ovarian Tumors Am. J. Pathol., January 1, 1999; 154(1): 119 - 125. [Abstract] [Full Text] [PDF]

				B. E. Clurman and P. Porter New insights into the tumor suppression function of P27Kip1 PNAS, December 22, 1998; 95(26): 15158 - 15160. [Full Text] [PDF]

				X. Qian, L. Jin, E. Kulig, and R. V. Lloyd DNA Methylation Regulates p27Kip1 Expression in Rodent Pituitary Cell Lines Am. J. Pathol., November 1, 1998; 153(5): 1475 - 1482. [Abstract] [Full Text] [PDF]

				H. J. Ahn, K. W. Kwon, Y. J. Choi, and N. H. Cho Expression of Cyclin E and Cyclin-Dependent Kinase Inhibitor, p27KIP1 in Uterine Endometrial Carcinoma: Relationship with p53 Status International Journal of Surgical Pathology, October 1, 1998; 6(4): 205 - 212. [Abstract] [PDF]

				G. V. Thomas, K. Szigeti, M. Murphy, G. Draetta, M. Pagano, and M. Loda Down-Regulation of p27 Is Associated with Development of Colorectal Adenocarcinoma Metastases Am. J. Pathol., September 1, 1998; 153(3): 681 - 687. [Abstract] [Full Text] [PDF]

				A. M. De Marzo, A. K. Meeker, J. I. Epstein, and D. S. Coffey Prostate Stem Cell Compartments : Expression of the Cell Cycle Inhibitor p27Kip1 inNormal, Hyperplastic, and Neoplastic Cells Am. J. Pathol., September 1, 1998; 153(3): 911 - 919. [Abstract] [Full Text] [PDF]

				H. Kawana, J.-i. Tamaru, T. Tanaka, A. Hirai, Y. Saito, M. Kitagawa, A. Mikata, K. Harigaya, and T. Kuriyama Role of p27Kip1 and Cyclin-Dependent Kinase 2 in the Proliferation of Non-Small Cell Lung Cancer Am. J. Pathol., August 1, 1998; 153(2): 505 - 513. [Abstract] [Full Text] [PDF]

				M. Erlanson, C. Portin, B. Linderholm, J. Lindh, G. Roos, and G. Landberg Expression of Cyclin E and the Cyclin-Dependent Kinase Inhibitor p27 in Malignant Lymphomas---Prognostic Implications Blood, August 1, 1998; 92(3): 770 - 777. [Abstract] [Full Text] [PDF]

				L. Quintanilla-Martinez, C. Thieblemont, F. Fend, S. Kumar, M. Pinyol, E. Campo, E. S. Jaffe, and M. Raffeld Mantle Cell Lymphomas Lack Expression of p27kip1, a Cyclin-Dependent Kinase Inhibitor Am. J. Pathol., July 1, 1998; 153(1): 175 - 182. [Abstract] [Full Text] [PDF]

				V. A. Florenes, G. M. Mælandsmo, R. S. Kerbel, J. M. Slingerland, J. M. Nesland, and R. Holm Protein Expression of the Cell-Cycle Inhibitor p27Kip1 in Malignant Melanoma : Inverse Correlation with Disease-Free Survival Am. J. Pathol., July 1, 1998; 153(1): 305 - 312. [Abstract] [Full Text] [PDF]

				R. Vrhovac, A. Delmer, R. Tang, J.-P. Marie, R. Zittoun, and F. Ajchenbaum-Cymbalista Prognostic Significance of the Cell Cycle Inhibitor p27Kip1 in Chronic B-Cell Lymphocytic Leukemia Blood, June 15, 1998; 91(12): 4694 - 4700. [Abstract] [Full Text] [PDF]

				J. M. Trowbridge, I. Rogatsky, and M. J. Garabedian Regulation of estrogen receptor transcriptional enhancement by the cyclin A/Cdk2 complex PNAS, September 16, 1997; 94(19): 10132 - 10137. [Abstract] [Full Text] [PDF]

				N. Ishida, M. Kitagawa, S. Hatakeyama, and K.-i. Nakayama Phosphorylation at Serine 10, a Major Phosphorylation Site of p27Kip1, Increases Its Protein Stability J. Biol. Chem., August 11, 2000; 275(33): 25146 - 25154. [Abstract] [Full Text] [PDF]

				V. O'Brien, G. J. Grindlay, and M. S. Campo Cell Transformation by the E5/E8 Protein of Bovine Papillomavirus Type 4. p27Kip1, ELEVATED THROUGH INCREASED PROTEIN SYNTHESIS, IS SEQUESTERED BY CYCLIN D1-CDK4 COMPLEXES J. Biol. Chem., August 31, 2001; 276(36): 33861 - 33868. [Abstract] [Full Text] [PDF]

				J. C. H. Donovan, A. Milic, and J. M. Slingerland Constitutive MEK/MAPK Activation Leads to p27Kip1 Deregulation and Antiestrogen Resistance in Human Breast Cancer Cells J. Biol. Chem., October 26, 2001; 276(44): 40888 - 40895. [Abstract] [Full Text] [PDF]

				M. Gstaiger, R. Jordan, M. Lim, C. Catzavelos, J. Mestan, J. Slingerland, and W. Krek Skp2 is oncogenic and overexpressed in human cancers PNAS, April 24, 2001; 98(9): 5043 - 5048. [Abstract] [Full Text] [PDF]

				S. Cariou, J. C. H. Donovan, W. M. Flanagan, A. Milic, N. Bhattacharya, and J. M. Slingerland Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells PNAS, August 1, 2000; 97(16): 9042 - 9046. [Abstract] [Full Text] [PDF]