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Identification of a 790-kilobase Region of Common Allelic Loss in Chromosome 10q25–q26 in Human Endometrial Cancer¹

Departments of Molecular Pathology [S. N., H. Y., A. H.] and Obstetrics and Gynecology [S. N., H. Y., S. S., A. Y.], Tohoku University School of Medicine, Sendai, 980-77, Japan

We previously identified two commonly deleted regions on chromosome bands 10q25–q26 in endometrial cancer: an 8-cM region and a 12-cM region. In the present study, we further studied the 8-cM region with 83 endometrial cancer specimens and 14 microsatellite markers and narrowed it down to a 1-cM region between D10S587 and D10S1723. This result was confirmed by two-color fluorescence in situ hybridization analysis. An association between histopathologically lower grade tumor and allelic loss (P = 0.03 by Fisher's exact test) was also observed. We also constructed a yeast artificial chromosome (YAC) contig and found that one YAC clone, which was 790 kb in size, harbored the whole 1-cM region of common allelic loss.

¹ This work was supported in part by the Ministry of Education, Science, Sports and Culture of Japan and the Ichiro Kanehara Foundation.

² To whom requests for reprints should be addressed. Phone: 81-22-717-8042; Fax: 81-22-717-8047; E-mail: horii@mail.cc.tohoku.ac.jp.

Received 1/23/97. Accepted 3/20/97.

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