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[Cancer Research 58, 14-19, January 1, 1998]
© 1998 American Association for Cancer Research
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High-Efficiency Gene Transfer and Selection of Human Hematopoietic Progenitor Cells with a Hybrid EBV/Retroviral Vector Expressing the Green Fluorescence Protein1

Francesco Grignani, Todd Kinsella, Amedea Mencarelli, Mauro Valtieri, Daniela Riganelli, Fausto Grignani, Luisa Lanfrancone, Cesare Peschle, Garry P. Nolan and Pier Giuseppe Pelicci2

Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy [P. G. P., L. L.]; Istituto di Medicina Interna e Scienze Oncologiche, Perugia University, 06100 Perugia, Italy [Fr. G., A. M., D. R., Fa. G., P. G. P.]; Hematology Oncology Laboratory, Istituto Superiore di Sanità 00161 Rome, Italy [Fr. G., M. V., C. P.]; Department of Molecular Pharmacology, Stanford University, Stanford, California 94305 [T. K., G. P. N.]; and Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107 [C. P.]

We report a retroviral expression vector (PINCO) that allows high-efficiency gene transfer and selection of hemopoietic progenitor cells (HPCs). The main characteristics of this vector are the presence outside the two long terminal repeats of the EBV origin of replication and the EBNA-1 gene and the presence in the retrovirus of the cDNA that encodes for the enhanced green fluorescence protein (GFP), controlled by a cytomegalovirus promoter. Transient transfection of PINCO in Phoenix packaging cells results in episomal propagation of the plasmid and generates viral titers as high as 107 colony-forming units/ml. Infection of established cell lines with the PINCO retrovirus yields more than 95% GFP-expressing cells. GFP expression remains stable for months in infected cell cultures and can easily be monitored by fluorescent microscopy or fluorescence-activated cell-sorting (FACS) analysis of living cells. The PINCO vector allows efficient expression of a second gene (thymidine kinase, Shc, and PML), and there is strict correlation between GFP and second gene expression levels in the infected cells. PINCO was used to infect human HPCs; infection efficiency was about 50%. GFP-positive cells can be FACS sorted to yield a homogeneous population of infected cells. FACS-sorted GFP-positive HPC cells have, with respect to unfractionated HPC cells, the same frequency of long-term culture initiating cells and an identical capacity to undergo multilineage and unilineage differentiation. The entire gene transfer procedure, from the transfection of the packaging cell line to the infection of target cells, requires less than a week. The high viral titer and the easy obtainment of homogeneously infected cell populations without drug selection procedures make PINCO an ideal vector for gene transfer of human primary hemopoietic cells.

1 Supported by Italy-USA Therapy of Tumors, ISS (Rome, Italy).

2 To whom requests for reprints should be addressed, at Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti, 435, 20141 Milan, Italy. Phone: 39-2-574-89-831; Fax: 39-2-574-89-851; E-mail: pgpelicci@ieo.cilea.it.

Received 10/22/97. Accepted 11/13/97.




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[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Ueda, S. Wang, N. Dumont, J. Y. Yi, Y. Koh, and C. L. Arteaga
Overexpression of HER2 (erbB2) in Human Breast Epithelial Cells Unmasks Transforming Growth Factor {beta}-induced Cell Motility
J. Biol. Chem., June 4, 2004; 279(23): 24505 - 24513.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. B. Osipovich, E. K. White-Grindley, G. G. Hicks, M. J. Roshon, C. Shaffer, J. H. Moore, and H. E. Ruley
Activation of cryptic 3' splice sites within introns of cellular genes following gene entrapment
Nucleic Acids Res., May 20, 2004; 32(9): 2912 - 2924.
[Abstract] [Full Text] [PDF]

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 BloodHome page
Y. Calle, G. E. Jones, C. Jagger, K. Fuller, M. P. Blundell, J. Chow, T. Chambers, and A. J. Thrasher
WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption
Blood, May 1, 2004; 103(9): 3552 - 3561.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Muller-Tidow, B. Steffen, T. Cauvet, L. Tickenbrock, P. Ji, S. Diederichs, B. Sargin, G. Kohler, M. Stelljes, E. Puccetti, et al.
Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells
Mol. Cell. Biol., April 1, 2004; 24(7): 2890 - 2904.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
C. A. O'Brien, D. Jia, L. I. Plotkin, T. Bellido, C. C. Powers, S. A. Stewart, S. C. Manolagas, and R. S. Weinstein
Glucocorticoids Act Directly on Osteoblasts and Osteocytes to Induce Their Apoptosis and Reduce Bone Formation and Strength
Endocrinology, April 1, 2004; 145(4): 1835 - 1841.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Audero, I. Cascone, F. Maniero, L. Napione, M. Arese, L. Lanfrancone, and F. Bussolino
Adaptor ShcA Protein Binds Tyrosine Kinase Tie2 Receptor and Regulates Migration and Sprouting but Not Survival of Endothelial Cells
J. Biol. Chem., March 26, 2004; 279(13): 13224 - 13233.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. M. Corcoran, F. Koentgen, W. Dietrich, M. Veale, and P. O. Humbert
All Known In Vivo Functions of the Oct-2 Transcription Factor Require the C-Terminal Protein Domain
J. Immunol., March 1, 2004; 172(5): 2962 - 2969.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Fanelli, A. Fantozzi, P. De Luca, S. Caprodossi, S.-i. Matsuzawa, M. A. Lazar, P. G. Pelicci, and S. Minucci
The Coiled-coil Domain Is the Structural Determinant for Mammalian Homologues of Drosophila Sina-mediated Degradation of Promyelocytic Leukemia Protein and Other Tripartite Motif Proteins by the Proteasome
J. Biol. Chem., February 13, 2004; 279(7): 5374 - 5379.
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 Proc. Natl. Acad. Sci. USAHome page
D. Chen and Q. Zhou
Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling
PNAS, February 3, 2004; 101(5): 1235 - 1240.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Egelhofer, G. Brandenburg, H. Martinius, P. Schult-Dietrich, G. Melikyan, R. Kunert, C. Baum, I. Choi, A. Alexandrov, and D. von Laer
Inhibition of Human Immunodeficiency Virus Type 1 Entry in Cells Expressing gp41-Derived Peptides
J. Virol., January 15, 2004; 78(2): 568 - 575.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. Huang, K. M. Hujer, Z. Wu, and R. T. Miller
The Ca2+-sensing receptor couples to G{alpha}12/13 to activate phospholipase D in Madin-Darby canine kidney cells
Am J Physiol Cell Physiol, January 1, 2004; 286(1): C22 - C30.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Moissoglu and I. H. Gelman
v-Src Rescues Actin-based Cytoskeletal Architecture and Cell Motility and Induces Enhanced Anchorage Independence during Oncogenic Transformation of Focal Adhesion Kinase-null Fibroblasts
J. Biol. Chem., November 28, 2003; 278(48): 47946 - 47959.
[Abstract] [Full Text] [PDF]

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 Clin. Cancer Res.Home page
A. T. Byrne, L. Ross, J. Holash, M. Nakanishi, L. Hu, J. I. Hofmann, G. D. Yancopoulos, and R. B. Jaffe
Vascular Endothelial Growth Factor-Trap Decreases Tumor Burden, Inhibits Ascites, and Causes Dramatic Vascular Remodeling in an Ovarian Cancer Model
Clin. Cancer Res., November 15, 2003; 9(15): 5721 - 5728.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
N. Casartelli, G. Di Matteo, M. Potesta, P. Rossi, and M. Doria
CD4 and Major Histocompatibility Complex Class I Downregulation by the Human Immunodeficiency Virus Type 1 Nef Protein in Pediatric AIDS Progression
J. Virol., November 1, 2003; 77(21): 11536 - 11545.
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 BloodHome page
F. Granucci, F. Petralia, M. Urbano, S. Citterio, F. Di Tota, L. Santambrogio, and P. Ricciardi-Castagnoli
The scavenger receptor MARCO mediates cytoskeleton rearrangements in dendritic cells and microglia
Blood, October 15, 2003; 102(8): 2940 - 2947.
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 BloodHome page
T. Beissert, E. Puccetti, A. Bianchini, S. Guller, S. Boehrer, D. Hoelzer, O. G. Ottmann, C. Nervi, and M. Ruthardt
Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571
Blood, October 15, 2003; 102(8): 2985 - 2993.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. Pesce, A. Orlandi, M. G. Iachininoto, S. Straino, A. R. Torella, V. Rizzuti, G. Pompilio, G. Bonanno, G. Scambia, and M. C. Capogrossi
Myoendothelial Differentiation of Human Umbilical Cord Blood-Derived Stem Cells in Ischemic Limb Tissues
Circ. Res., September 5, 2003; 93 (5): e51 - e62.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Haan, P. Ferguson, U. Sommer, M. Hiremath, D. W. McVicar, P. C. Heinrich, J. A. Johnston, and N. A. Cacalano
Tyrosine Phosphorylation Disrupts Elongin Interaction and Accelerates SOCS3 Degradation
J. Biol. Chem., August 22, 2003; 278(34): 31972 - 31979.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
H. Niu, G. Cattoretti, and R. Dalla-Favera
BCL6 Controls the Expression of the B7-1/CD80 Costimulatory Receptor in Germinal Center B Cells
J. Exp. Med., July 21, 2003; 198(2): 211 - 221.
[Abstract] [Full Text] [PDF]

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 BloodHome page
A. Zeuner, F. Pedini, M. Signore, U. Testa, E. Pelosi, C. Peschle, and R. De Maria
Stem cell factor protects erythroid precursor cells from chemotherapeutic agents via up-regulation of BCL-2 family proteins
Blood, July 1, 2003; 102(1): 87 - 93.
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 BloodHome page
A. Tonks, L. Pearn, A. J. Tonks, L. Pearce, T. Hoy, S. Phillips, J. Fisher, J. R. Downing, A. K. Burnett, and R. L. Darley
The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells
Blood, January 15, 2003; 101(2): 624 - 632.
[Abstract] [Full Text] [PDF]

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 Infect. Immun.Home page
C. J. Riendeau and H. Kornfeld
THP-1 Cell Apoptosis in Response to Mycobacterial Infection
Infect. Immun., January 1, 2003; 71(1): 254 - 259.
[Abstract] [Full Text] [PDF]

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 BloodHome page
R. K. Vangala, M. S. Heiss-Neumann, J. S. Rangatia, S. M. Singh, C. Schoch, D. G. Tenen, W. Hiddemann, and G. Behre
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia
Blood, January 1, 2003; 101(1): 270 - 277.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Rangatia, R. K. Vangala, N. Treiber, P. Zhang, H. Radomska, D. G. Tenen, W. Hiddemann, and G. Behre
Downregulation of c-Jun Expression by Transcription Factor C/EBP{alpha} Is Critical for Granulocytic Lineage Commitment
Mol. Cell. Biol., December 15, 2002; 22(24): 8681 - 8694.
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Home page
 Mol. Cell. Biol.Home page
R. Piva, J. Liu, R. Chiarle, A. Podda, M. Pagano, and G. Inghirami
In Vivo Interference with Skp1 Function Leads to Genetic Instability and Neoplastic Transformation
Mol. Cell. Biol., December 1, 2002; 22(23): 8375 - 8387.
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Home page
 Cancer Res.Home page
E. Puccetti, D. Obradovic, T. Beissert, A. Bianchini, B. Washburn, F. Chiaradonna, S. Boehrer, D. Hoelzer, O. G. Ottmann, P. G. Pelicci, et al.
AML-associated Translocation Products Block Vitamin D3-induced Differentiation by Sequestering the Vitamin D3 Receptor
Cancer Res., December 1, 2002; 62(23): 7050 - 7058.
[Abstract] [Full Text] [PDF]

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 BloodHome page
R. L. Darley, L. Pearn, N. Omidvar, M. Sweeney, J. Fisher, S. Phillips, T. Hoy, and A. K. Burnett
Protein kinase C mediates mutant N-Ras-induced developmental abnormalities in normal human erythroid cells
Blood, December 1, 2002; 100(12): 4185 - 4192.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. A. Jeffers, D. A. Sanders, and A. Sanchez
Covalent Modifications of the Ebola Virus Glycoprotein
J. Virol., November 13, 2002; 76(24): 12463 - 12472.
[Abstract] [Full Text] [PDF]

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 JCBHome page
R. C. Ireton, M. A. Davis, J. van Hengel, D. J. Mariner, K. Barnes, M. A. Thoreson, P. Z. Anastasiadis, L. Matrisian, L. M. Bundy, L. Sealy, et al.
A novel role for p120 catenin in E-cadherin function
J. Cell Biol., November 7, 2002; 159(3): 465 - 476.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
G. Pelicci, F. Troglio, A. Bodini, R. M. Melillo, V. Pettirossi, L. Coda, A. De Giuseppe, M. Santoro, and P. G. Pelicci
The Neuron-Specific Rai (ShcC) Adaptor Protein Inhibits Apoptosis by Coupling Ret to the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway
Mol. Cell. Biol., October 15, 2002; 22(20): 7351 - 7363.
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 BloodHome page
S. Minucci, S. Monestiroli, S. Giavara, S. Ronzoni, F. Marchesi, A. Insinga, D. Diverio, P. Gasparini, M. Capillo, E. Colombo, et al.
PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors
Blood, September 26, 2002; 100(8): 2989 - 2995.
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 BloodHome page
M. Corada, L. Zanetta, F. Orsenigo, F. Breviario, M. G. Lampugnani, S. Bernasconi, F. Liao, D. J. Hicklin, P. Bohlen, and E. Dejana
A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
Blood, July 18, 2002; 100(3): 905 - 911.
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 BloodHome page
A. B. Maurer, C. Wichmann, A. Gross, H. Kunkel, T. Heinzel, M. Ruthardt, B. Groner, and M. Grez
The Stat5-RARalpha fusion protein represses transcription and differentiation through interaction with a corepressor complex
Blood, April 15, 2002; 99(8): 2647 - 2652.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Fluiter, A. L. M. A. ten Asbroek, M. van Groenigen, M. Nooij, M. C. G. Aalders, and F. Baas
Tumor Genotype-specific Growth Inhibition in Vivo by Antisense Oligonucleotides against a Polymorphic Site of the Large Subunit of Human RNA Polymerase II
Cancer Res., April 1, 2002; 62(7): 2024 - 2028.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Zanetti, M. G. Lampugnani, G. Balconi, F. Breviario, M. Corada, L. Lanfrancone, and E. Dejana
Vascular Endothelial Growth Factor Induces Shc Association With Vascular Endothelial Cadherin: A Potential Feedback Mechanism to Control Vascular Endothelial Growth Factor Receptor-2 Signaling
Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 617 - 622.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. G. Lampugnani, A. Zanetti, F. Breviario, G. Balconi, F. Orsenigo, M. Corada, R. Spagnuolo, M. Betson, V. Braga, and E. Dejana
VE-Cadherin Regulates Endothelial Actin Activating Rac and Increasing Membrane Association of Tiam
Mol. Biol. Cell, April 1, 2002; 13(4): 1175 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Gui, J. Li, L.-J. Wen, R. R. Hardy, and K. Hayakawa
TCR{beta} Chain Influences But Does Not Solely Control Autoreactivity of V{alpha}14J281T Cells
J. Immunol., December 1, 2001; 167(11): 6239 - 6246.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. D. Southall, J. S. Isenberg, H. Nakshatri, Q. Yi, Y. Pei, D. F. Spandau, and J. B. Travers
The Platelet-activating Factor Receptor Protects Epidermal Cells from Tumor Necrosis Factor (TNF) alpha and TNF-related Apoptosis-inducing Ligand-induced Apoptosis through an NF-kappa B-dependent Process
J. Biol. Chem., November 30, 2001; 276(49): 45548 - 45554.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Zelcer, T. Saeki, G. Reid, J. H. Beijnen, and P. Borst
Characterization of Drug Transport by the Human Multidrug Resistance Protein 3 (ABCC3)
J. Biol. Chem., November 30, 2001; 276(49): 46400 - 46407.
[Abstract] [Full Text] [PDF]


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