| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
First Department of Surgery [A. S., F. M., T. I., K. I., S. K.] and Laboratory Medicine [T. K.], Shinshu University School of Medicine, Matsumoto 390-8621, Japan, and Laboratory of Pathology, Aichi Cancer Center Research Institute, Nagoya 464-0021, Japan [N. S., M. T.]
No previous report has demonstrated the relationship between Helicobacter pylori (HP) infection and gastric carcinogenesis in an experimental animal model. A total of 170 male Mongolian gerbils (MGs) were divided into nine groups (18 
n 20 for each group). MGs of four groups were inoculated with HP before or after continuous N-methyl-N-nitrosourea (MNU) administration via the drinking water. Both intestinal-type and diffuse-type adenocarcinomas, including signet ring-cell carcinomas, were found at 40 weeks after the study commenced, but only in the HP inoculation groups with MNU exposure and not in the MNU alone or HP inoculation alone control groups. The present findings demonstrate that HP infection increases the incidence of MNU-induced adenocarcinoma of the glandular stomach in MGs.
1 To whom requests for reprints should be addressed, at First Department of Surgery, Shinshu University School of Medicine, Asahi 3-1-1, 390-8621 Matsumoto, Japan. Phone: 81-263-37-2654; Fax: 81-263-35-1282; E-mail: asugiyama@surg101.shinshu-u.ac.jp.
Received 1/30/98. Accepted 3/31/98.
This article has been cited by other articles:
|
|
 |
|
  K. Chochi, T. Ichikura, M. Kinoshita, T. Majima, N. Shinomiya, H. Tsujimoto, T. Kawabata, H. Sugasawa, S. Ono, S. Seki, et al. Helicobacter pylori Augments Growth of Gastric Cancers via the Lipopolysaccharide-Toll-like Receptor 4 Pathway whereas Its Lipopolysaccharide Attenuates Antitumor Activities of Human Mononuclear Cells Clin. Cancer Res., May 15, 2008; 14(10): 2909 - 2917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yanai, S. Maeda, W. Shibata, Y. Hikiba, K. Sakamoto, H. Nakagawa, T. Ohmae, Y. Hirata, K. Ogura, S. Muto, et al. Activation of I{kappa}B Kinase and NF-{kappa}B Is Essential for Helicobacter pylori-Induced Chronic Gastritis in Mongolian Gerbils Infect. Immun., February 1, 2008; 76(2): 781 - 787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tsukamoto, T. Mizoshita, and M. Tatematsu Animal Models of Stomach Carcinogenesis Toxicol Pathol, August 1, 2007; 35(5): 636 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Herceg Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors Mutagenesis, March 1, 2007; 22(2): 91 - 103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Kusters, A. H. M. van Vliet, and E. J. Kuipers Pathogenesis of Helicobacter pylori Infection Clin. Microbiol. Rev., July 1, 2006; 19(3): 449 - 490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Maekita, K. Nakazawa, M. Mihara, T. Nakajima, K. Yanaoka, M. Iguchi, K. Arii, A. Kaneda, T. Tsukamoto, M. Tatematsu, et al. High Levels of Aberrant DNA Methylation in Helicobacter pylori-Infected Gastric Mucosae and its Possible Association with Gastric Cancer Risk Clin. Cancer Res., February 1, 2006; 12(3): 989 - 995. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Nakagawa, T. Osaki, Y. Fujioka, H. Yamaguchi, and S. Kamiya Long-Term Infection of Mongolian Gerbils with Helicobacter pylori: Microbiological, Histopathological, and Serological Analyses Clin. Vaccine Immunol., February 1, 2005; 12(2): 347 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kumagai, J. Yan, D. Y. Graham, M. Tozuka, Y. Okimura, T. Ikeno, A. Sugiyama, T. Katsuyama, and H. Ota Serum Immunoglobulin G Immune Response to Helicobacter pylori Antigens in Mongolian Gerbils J. Clin. Microbiol., April 1, 2001; 39(4): 1283 - 1288. [Abstract] [Full Text]
|
|
|
|
|
|
A. Occhialini, A. Marais, M. Urdaci, R. Sierra, N. Munoz, A. Covacci, and F. Megraud Composition and Gene Expression of the cag Pathogenicity Island in Helicobacter pylori Strains Isolated from Gastric Carcinoma and Gastritis Patients in Costa Rica Infect. Immun., March 1, 2001; 69(3): 1902 - 1908. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Peterson, S. J. Danon, and K. A. Eaton Comparison of Gastritis and Gastric Epithelial Proliferation in Helicobacter heilmannii-infected Nude and BALB/c Mice Vet. Pathol., March 1, 2001; 38(2): 173 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. V. Solnick and D. B. Schauer Emergence of Diverse Helicobacter Species in the Pathogenesis of Gastric and Enterohepatic Diseases Clin. Microbiol. Rev., January 1, 2001; 14(1): 59 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Touati, M. Hofnung, J.-M. Thiberge, V. Michel, A. Labigne, and P. J. Jenks Short-term infection with Helicobacter pylori and 1 week exposure to metronidazole does not enhance gastric mutation frequency in transgenic mice J. Antimicrob. Chemother., December 1, 2000; 46(6): 987 - 992. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tsutsui, I. Taneike, T. Ohara, S. Goshi, S. Kojio, N. Iwakura, H. Matsumaru, N. Wakisaka-Saito, H.-M. Zhang, and T. Yamamoto A Novel Action of the Proton Pump Inhibitor Rabeprazole and Its Thioether Derivative against the Motility of Helicobacter pylori Antimicrob. Agents Chemother., November 1, 2000; 44(11): 3069 - 3073. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Akre, L. B. Signorello, L. Engstrand, R. Bergström, S. Larsson, B. I. Eriksson, and O. Nyrén Risk for Gastric Cancer after Antibiotic Prophylaxis in Patients Undergoing Hip Replacement Cancer Res., November 1, 2000; 60(22): 6376 - 6380. [Abstract] [Full Text]
|
|
|
|
|
|
H. Kuwahara, Y. Miyamoto, T. Akaike, T. Kubota, T. Sawa, S. Okamoto, and H. Maeda Helicobacter pylori Urease Suppresses Bactericidal Activity of Peroxynitrite via Carbon Dioxide Production Infect. Immun., August 1, 2000; 68(8): 4378 - 4383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Shimizu, Y. Ikehara, K.-i. Inada, H. Nakanishi, T. Tsukamoto, K. Nozaki, M. Kaminishi, S. Kuramoto, A. Sugiyama, T. Katsuyama, et al. Eradication Diminishes Enhancing Effects of Helicobacter pylori Infection on Glandular Stomach Carcinogenesis in Mongolian Gerbils Cancer Res., March 1, 2000; 60(6): 1512 - 1514. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. T.K.-H. Stadtlander and J. W. waterbor Molecular epidemiology, pathogenesis and prevention of gastric cancer Carcinogenesis, December 1, 1999; 20(12): 2195 - 2208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tokieda, S. Honda, T. Fujioka, and M. Nasu Effect of Helicobacter pylori infection on the N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in Mongolian gerbils Carcinogenesis, July 1, 1999; 20(7): 1261 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Goto, K. Haruma, Y. Kitadai, M. Ito, M. Yoshihara, K. Sumii, N. Hayakawa, and G. Kajiyama Enhanced Expression of Inducible Nitric Oxide Synthase and Nitrotyrosine in Gastric Mucosa of Gastric Cancer Patients Clin. Cancer Res., June 1, 1999; 5(6): 1411 - 1415. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Goto, A. Nishizono, T. Fujioka, J. Ikewaki, K. Mifune, and M. Nasu Local Secretory Immunoglobulin A and Postimmunization Gastritis Correlate with Protection against Helicobacter pylori Infection after Oral Vaccination of Mice Infect. Immun., May 1, 1999; 67(5): 2531 - 2539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Shimizu, K.-i. Inada, H. Nakanishi, T. Tsukamoto, Y. Ikehara, M. Kaminishi, S. Kuramoto, A. Sugiyama, T. Katsuyama, and M. Tatematsu Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens Carcinogenesis, April 1, 1999; 20(4): 669 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ikeno, H. Ota, A. Sugiyama, K. Ishida, T. Katsuyama, R. M. Genta, and S. Kawasaki Helicobacter pylori-Induced Chronic Active Gastritis, Intestinal Metaplasia, and Gastric Ulcer in Mongolian Gerbils Am. J. Pathol., March 1, 1999; 154(3): 951 - 960. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
