This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Takahashi, H. Articles by Nakagawara, A. Search for Related Content PubMed PubMed Citation Articles by Takahashi, H. Articles by Nakagawara, A.

Mutation, Allelotyping, and Transcription Analyses of the p73 Gene in Prostatic Carcinoma¹

Department of Pathology, Jikei University School of Medicine, Tokyo 105, Japan [H. T., M. F., S. W., S. A.]; Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260, Japan [S. I., Y. N., A. N.]; and Second Department of Pathology, School of Medicine, Mie University, Mie 514, Japan [M. W., R. Y.]

A novel gene, p73, encoding a protein with significant homology to p53, was recently identified at 1p36. To investigate penetrance of p73 in prostatic carcinogenesis, mutation, allelotyping, and transcription analyses of p73 were performed in prostatic carcinoma. No types of mutation causing amino acid substitutions or frameshifts were found in 106 cases examined. Loss of heterozygosity in the gene was found in 2 of 38 cases (5.3%). Various expression levels of p73 variant were observed in tumor compared with those in normal tissue. These data suggest that the p73 gene is not playing an essential role, but expression of p73 may associate with tumor growth in prostatic carcinogenesis.

¹ This work was supported in part by Grant-in-Aid for Encouragement of Young Scientists 09770133 from the Ministry of Education, Science, Sports and Culture of Japan.

² To whom requests for reprints should be addressed, at Division of Biochemistry, Chiba Cancer Center Research Institute, Chiba 260, Japan.

Received 1/21/98. Accepted 3/31/98.

This article has been cited by other articles:

				H. Li, L. Yao, T. Ouyang, J. Li, T. Wang, Z. Fan, T. Fan, B. Dong, B. Lin, J. Li, et al. Association of p73 G4C14-to-A4T14 (GC/AT) polymorphism with breast cancer survival Carcinogenesis, February 1, 2007; 28(2): 372 - 377. [Abstract] [Full Text] [PDF]

				M Guan and Y Chen Aberrant expression of {Delta}Np73 in benign and malignant tumours of the prostate: correlation with Gleason score J. Clin. Pathol., November 1, 2005; 58(11): 1175 - 1179. [Abstract] [Full Text] [PDF]

				S. W. Song, G. N. Fuller, H. Zheng, and W. Zhang Inactivation of the Invasion Inhibitory Gene IIp45 by Alternative Splicing in Gliomas Cancer Res., May 1, 2005; 65(9): 3562 - 3567. [Abstract] [Full Text] [PDF]

				G. Li, L.-E Wang, R. M. Chamberlain, C. I. Amos, M. R. Spitz, and Q. Wei p73 G4C14-to-A4T14 Polymorphism and Risk of Lung Cancer Cancer Res., October 1, 2004; 64(19): 6863 - 6866. [Abstract] [Full Text] [PDF]

				G. Li, E. M. Sturgis, L.-E. Wang, R. M. Chamberlain, C. I. Amos, M. R. Spitz, A. K. El-Naggar, W. K. Hong, and Q. Wei Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck Carcinogenesis, October 1, 2004; 25(10): 1911 - 1916. [Abstract] [Full Text] [PDF]

				S. S. Liu, R. C.-Y. Leung, K. Y.-K. Chan, P.-M. Chiu, A. N.-Y. Cheung, K.-F. Tam, T.-Y. Ng, L.-C. Wong, and H. Y.-S. Ngan p73 Expression Is Associated with the Cellular Radiosensitivity in Cervical Cancer after Radiotherapy Clin. Cancer Res., May 15, 2004; 10(10): 3309 - 3316. [Abstract] [Full Text] [PDF]

				M. Marabese, F. Vikhanskaya, C. Rainelli, T. Sakai, and M. Broggini DNA damage induces transcriptional activation of p73 by removing C-EBP{alpha} repression on E2F1 Nucleic Acids Res., November 15, 2003; 31(22): 6624 - 6632. [Abstract] [Full Text] [PDF]

				T. Stiewe, J. Stanelle, C. C. Theseling, B. Pollmeier, M. Beitzinger, and B. M. Putzer Inactivation of Retinoblastoma (RB) Tumor Suppressor by Oncogenic Isoforms of the p53 Family Member p73 J. Biol. Chem., April 11, 2003; 278(16): 14230 - 14236. [Abstract] [Full Text] [PDF]

				W. J. Freebern, J. L. Smith, S. S. Chaudhry, C. M. Haggerty, and K. Gardner Novel Cell-specific and Dominant Negative Anti-apoptotic Roles of p73 in Transformed Leukemia Cells J. Biol. Chem., January 17, 2003; 278(4): 2249 - 2255. [Abstract] [Full Text] [PDF]

				Z. Serber, H. C. Lai, A. Yang, H. D. Ou, M. S. Sigal, A. E. Kelly, B. D. Darimont, P. H. G. Duijf, H. van Bokhoven, F. McKeon, et al. A C-Terminal Inhibitory Domain Controls the Activity of p63 by an Intramolecular Mechanism Mol. Cell. Biol., December 15, 2002; 22(24): 8601 - 8611. [Abstract] [Full Text] [PDF]

				X.-F. Sun p73 Overexpression Is a Prognostic Factor in Patients with Colorectal Adenocarcinoma Clin. Cancer Res., January 1, 2002; 8(1): 165 - 170. [Abstract] [Full Text] [PDF]

				M. S. Irwin and W. G. Kaelin p53 Family Update: p73 and p63 Develop Their Own Identities Cell Growth Differ., July 1, 2001; 12(7): 337 - 349. [Full Text] [PDF]

				A. K. El-Naggar, S. Lai, G. L. Clayman, B. Mims, S. M. Lippman, M. Coombes, M. A. Luna, and G. Lozano p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas Carcinogenesis, May 1, 2001; 22(5): 729 - 735. [Abstract] [Full Text] [PDF]

				F. Vikhanskaya, S. Marchini, M. Marabese, E. Galliera, and M. Broggini p73{{alpha}} Overexpression Is Associated with Resistance to Treatment with DNA-damaging Agents in a Human Ovarian Cancer Cell Line Cancer Res., February 1, 2001; 61(3): 935 - 938. [Abstract] [Full Text]

				C.-L. Chen, S.-M. Ip, D. Cheng, L.-C. Wong, and H. Y. S. Ngan p73 Gene Expression in Ovarian Cancer Tissues and Cell Lines Clin. Cancer Res., October 1, 2000; 6(10): 3910 - 3915. [Abstract] [Full Text]

				B.-J. Park, S.-J. Lee, J. I. Kim, S.-J. Lee, C.-H. Lee, S.-G. Chang, J.-H. Park, and S.-G. Chi Frequent Alteration of p63 Expression in Human Primary Bladder Carcinomas Cancer Res., July 1, 2000; 60(13): 3370 - 3374. [Abstract] [Full Text]

				K. Hibi, B. Trink, M. Patturajan, W. H. Westra, O. L. Caballero, D. E. Hill, E. A. Ratovitski, J. Jen, and D. Sidransky AIS is an oncogene amplified in squamous cell carcinoma PNAS, May 9, 2000; 97(10): 5462 - 5467. [Abstract] [Full Text] [PDF]

				M.-J. Kang, B.-J. Park, D.-S. Byun, J.-I. Park, H.-J. Kim, J.-H. Park, and S.-G. Chi Loss of Imprinting and Elevated Expression of Wild-Type p73 in Human Gastric Adenocarcinoma Clin. Cancer Res., May 1, 2000; 6(5): 1767 - 1771. [Abstract] [Full Text] [PDF]

				Y. C. Cai, G.-y. Yang, Y. Nie, L.-D. Wang, X. Zhao, Y.-l. Song, D. N. Seril, J. Liao, E. P. Xing, and C. S. Yang Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53 Carcinogenesis, April 1, 2000; 21(4): 683 - 689. [Abstract] [Full Text] [PDF]

				F. Vikhanskaya, M. D'Incalci, and M. Broggini p73 competes with p53 and attenuates its response in a human ovarian cancer cell line Nucleic Acids Res., January 15, 2000; 28(2): 513 - 519. [Abstract] [Full Text] [PDF]

				M Levrero, V De Laurenzi, A Costanzo, J Gong, J. Wang, and G Melino The p53/p63/p73 family of transcription factors: overlapping and distinct functions J. Cell Sci., January 5, 2000; 113(10): 1661 - 1670. [Abstract] [PDF]

				S. Wienzek, J. Roth, and M. Dobbelstein E1B 55-Kilodalton Oncoproteins of Adenovirus Types 5 and 12 Inactivate and Relocalize p53, but Not p51 or p73, and Cooperate with E4orf6 Proteins To Destabilize p53 J. Virol., January 1, 2000; 74(1): 193 - 202. [Abstract] [Full Text]

				J. Roth and M. Dobbelstein Failure of viral oncoproteins to target the p53-homologue p51A J. Gen. Virol., December 1, 1999; 80(12): 3251 - 3255. [Abstract] [Full Text]

				T. Ozaki, M. Naka, N. Takada, M. Tada, S. Sakiyama, and A. Nakagawara Deletion of the COOH-Terminal Region of p73{{alpha}} Enhances Both Its Transactivation Function and DNA-binding Activity but Inhibits Induction of Apoptosis in Mammalian Cells Cancer Res., December 1, 1999; 59(23): 5902 - 5907. [Abstract] [Full Text] [PDF]

				U. R. Peters, M. P. Tschan, K. A. Kreuzer, G. Baskaynak, U. Lass, A. Tobler, M. F. Fey, and C. A. Schmidt Distinct Expression Patterns of the p53-Homologue p73 in Malignant and Normal Hematopoiesis Assessed by a Novel Real-Time Reverse Transcription-Polymerase Chain Reaction Assay and Protein Analysis Cancer Res., September 1, 1999; 59(17): 4233 - 4236. [Abstract] [Full Text] [PDF]

				K. L. van Golen, S. Davies, Z. Fen Wu, Y. Wang, C. D. Bucana, H. Root, S. Chandrasekharappa, M. Strawderman, S. P. Ethier, and S. D. Merajver A Novel Putative Low-Affinity Insulin-like Growth Factor-binding Protein, LIBC (Lost in Inflammatory Breast Cancer), and RhoC GTPase Correlate with the Inflammatory Breast Cancer Phenotype Clin. Cancer Res., September 1, 1999; 5(9): 2511 - 2519. [Abstract] [Full Text] [PDF]

				S. Kawano, C. W. Miller, A. F. Gombart, C. R. Bartram, Y. Matsuo, H. Asou, A. Sakashita, J. Said, E. Tatsumi, and H. P. Koeffler Loss of p73 Gene Expression in Leukemias/Lymphomas Due to Hypermethylation Blood, August 1, 1999; 94(3): 1113 - 1120. [Abstract] [Full Text] [PDF]

				A. Tannapfel, M. Wasner, K. Krause, F. Geissler, A. Katalinic, J. Hauss, J. Mossner, K. Engeland, and C. Wittekind Expression of p73 and Its Relation to Histopathology and Prognosis in Hepatocellular Carcinoma J Natl Cancer Inst, July 7, 1999; 91(13): 1154 - 1158. [Abstract] [Full Text] [PDF]

				A. I. Zaika, S. Kovalev, N. D. Marchenko, and U. M. Moll Overexpression of the Wild Type p73 Gene in Breast Cancer Tissues and Cell Lines Cancer Res., July 1, 1999; 59(13): 3257 - 3263. [Abstract] [Full Text] [PDF]

				P. G. Corn, S. J. Kuerbitz, M. M. van Noesel, M. Esteller, N. Compitello, S. B. Baylin, and J. G. Herman Transcriptional Silencing of the p73 Gene in Acute Lymphoblastic Leukemia and Burkitt's Lymphoma Is Associated with 5' CpG Island Methylation Cancer Res., July 1, 1999; 59(14): 3352 - 3356. [Abstract] [Full Text] [PDF]

				S.-G. Chi, S.-G. Chang, S.-J. Lee, C.-H. Lee, J. I. Kim, and J.-H. Park Elevated and Biallelic Expression of p73 Is Associated with Progression of Human Bladder Cancer Cancer Res., June 1, 1999; 59(12): 2791 - 2793. [Abstract] [Full Text] [PDF]

				N. Takada, T. Ozaki, S. Ichimiya, S. Todo, and A. Nakagawara Identification of a Transactivation Activity in the COOH-Terminal Region of p73 Which Is Impaired in the Naturally Occurring Mutants Found inHuman Neuroblastomas Cancer Res., June 1, 1999; 59(12): 2810 - 2814. [Abstract] [Full Text] [PDF]

				M. Herranz, J. Santos, E. Salido, J. Ferna ndez-Piqueras, and M. Serrano Mouse p73 Gene Maps to the Distal Part of Chromosome 4 and Might Be Involved in the Progression of {{gamma}}-Radiation-induced T-cell Lymphomas Cancer Res., May 1, 1999; 59(9): 2068 - 2071. [Abstract] [Full Text] [PDF]

				W. G. Kaelin Jr. The Emerging p53 Gene Family J Natl Cancer Inst, April 7, 1999; 91(7): 594 - 598. [Abstract] [Full Text] [PDF]

				M. Nozaki, M. Tada, H. Kobayashi, C.-L. Zhang, Y. Sawamura, H. Abe, N. Ishii, and E. G. Van Meir Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression Neuro-oncol, April 1, 1999; 1(2): 124 - 137. [Abstract] [PDF]

				H. Tsao, X. Zhang, P. Majewski, and F. G. Haluska Mutational and Expression Analysis of the p73 Gene in Melanoma Cell Lines Cancer Res., January 1, 1999; 59(1): 172 - 174. [Abstract] [Full Text] [PDF]

				V. De Laurenzi, A. Costanzo, D. Barcaroli, A. Terrinoni, M. Falco, M. Annicchiarico-Petruzzelli, M. Levrero, and G. Melino Two New p73 Splice Variants, {gamma} and {delta}, with Different Transcriptional Activity J. Exp. Med., November 2, 1998; 188(9): 1763 - 1768. [Abstract] [Full Text] [PDF]

				S. Strano, E. Munarriz, M. Rossi, B. Cristofanelli, Y. Shaul, L. Castagnoli, A. J. Levine, A. Sacchi, G. Cesareni, M. Oren, et al. Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73 J. Biol. Chem., September 15, 2000; 275(38): 29503 - 29512. [Abstract] [Full Text] [PDF]