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Location of Several Putative Genes Possibly Involved in Human Breast Cancer Progression¹

Laboratoire d'Oncogénétique [K. D., I. B., M-H. C., R. L.] and Laboratoire d'Anatomo-cyto-pathologie [M. B.], Centre René Huguenin, St-Cloud, France

Cancer is a genetic disease resulting from an accumulation of genetic abnormalities in various regulatory genes. Most studies on genetic alterations in human breast cancer have involved primary tumors. The possible involvement of specific tumor suppressor genes in the later stages of cancer progression is poorly documented. We investigated allelic losses associated with breast cancer progression by analyzing 55 polymorphic markers on 11 autosomal chromosomes in a series of 49 relapses (23 local recurrences and 26 distant metastases). All of the loss of heterozygosity (LOH) regions reported in primary breast tumors were frequent in both series of relapses. These results suggest that the allelic losses that are common to the different series of samples occur very early during tumor progression. This study points to candidate metastasis-related genes targeted by LOH on chromosome arms 3p21.3, 16q22.2–23.2, and, possibly, 7q31 but provides no clear evidence of LOH affecting previously described metastasis-related genes such as NME1, MTS1, and TSG101.

¹ This work was supported by the Ligue Nationale de Lutte Contre le Cancer; the Comités Régionaux de l'Essonne, des Hauts de Seine et des Yvelines; and the Association pour la Recherche sur le Cancer. K. D. is supported by a grant from the Ligue Départementale de l'Essonne. R. L. is a research director with the Institut National de la Santé et de la Recherche Médicale.

² To whom requests for reprints should be addressed, at Laboratoire d'Oncogénétique, Centre René Huguenin, 35 rue Dailly, F-92211 St-Cloud, France. Phone: 33 (1) 47 11 15 66; Fax: 33 (1) 47 11 16 96.

Received 10/27/97. Accepted 3/31/98.

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