Cancer Research CTRC-AACR San Antonio Breast Cancer Symposium Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 58, 2520-2523, June 15, 1998]
© 1998 American Association for Cancer Research
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Voeller, H. J.
Right arrow Articles by Gelmann, E. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Voeller, H. J.
Right arrow Articles by Gelmann, E. P.

ß-Catenin Mutations in Human Prostate Cancer1

H. James Voeller, Cristina I. Truica and Edward P. Gelmann2

Division of Hematology/Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, D. C. 20007-2197

ß-Catenin plays essential roles in both intercellular adhesion and signal transduction. As a signaling molecule, ß-catenin supplies an activating domain to the T-cell factor/lymphoid enhancer-binding factor family of DNA-binding proteins and activates gene transcription. Posttranslational stabilization of ß-catenin, leading to elevated protein levels and constitutive gene activation, has been proposed as an important step in oncogenesis. Stabilization of ß-catenin can occur through mutation to highly conserved amino acids encoded in exon 3 of the ß-catenin gene (CTNNB1). To determine whether this pathway of malignant transformation is important in prostate cancer, we analyzed 104 prostate cancer tissue specimens, 4 prostate cancer cell lines, and 3 prostate tumor xenografts for activating mutations in exon 3 of CTNNB1. Mutations were detected in 5 of the 104 prostate cancer tissue samples. Four of the five mutations involved serine or threonine residues implicated in the degradation of ß-catenin. A fifth tumor had a mutation at codon 32, changing a highly conserved aspartic acid to a tyrosine. Mutational analysis of multiple regions from several tumor samples showed that the ß-catenin mutations were present focally and therefore may occur during tumor progression.

1 This work was supported in part by an award from the CaPCURE Foundation. The Macromolecular Synthesis and Sequencing Core Facility of Lombardi Cancer Center is supported by USPHS Grant P30-CA-51008.

2 To whom requests for reprints should be addressed, at Lombardi Cancer Center, 3800 Reservoir Road NW, Washington, D.C. 20007-2197. Phone: (202) 687-2207; Fax: (202) 784-1229; E-mail: gelmanne@gunet.georgetown.edu.

Received 3/ 2/98. Accepted 4/28/98.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
M. J. Hayes, D. Thomas, A. Emmons, T. J. Giordano, and C. G. Kleer
Genetic Changes of Wnt Pathway Genes Are Common Events in Metaplastic Carcinomas of the Breast
Clin. Cancer Res., July 1, 2008; 14(13): 4038 - 4044.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
V. R. Placencio, A.-R. Sharif-Afshar, X. Li, H. Huang, C. Uwamariya, E. G. Neilson, M. M. Shen, R. J. Matusik, S. W. Hayward, and N. A. Bhowmick
Stromal Transforming Growth Factor-{beta} Signaling Mediates Prostatic Response to Androgen Ablation by Paracrine Wnt Activity
Cancer Res., June 15, 2008; 68(12): 4709 - 4718.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
H. Yoshikawa, K. Matsubara, X. Zhou, S. Okamura, T. Kubo, Y. Murase, Y. Shikauchi, M. Esteller, J. G. Herman, X. Wei Wang, et al.
WNT10B Functional Dualism: beta-Catenin/Tcf-dependent Growth Promotion or Independent Suppression with Deregulated Expression in Cancer
Mol. Biol. Cell, November 1, 2007; 18(11): 4292 - 4303.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. J. Bruxvoort, H. M. Charbonneau, T. A. Giambernardi, J. C. Goolsby, C.-N. Qian, C. R. Zylstra, D. R. Robinson, P. Roy-Burman, A. K. Shaw, B. D. Buckner-Berghuis, et al.
Inactivation of Apc in the Mouse Prostate Causes Prostate Carcinoma
Cancer Res., March 15, 2007; 67(6): 2490 - 2496.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
H. Dvory-Sobol, E. Sagiv, D. Kazanov, A. Ben-Ze'ev, and N. Arber
Targeting the active {beta}-catenin pathway to treat cancer cells.
Mol. Cancer Ther., November 1, 2006; 5(11): 2861 - 2871.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S.-Y. Chen, G. Wulf, X. Z. Zhou, M. A. Rubin, K. P. Lu, and S. P. Balk
Activation of {beta}-Catenin Signaling in Prostate Cancer by Peptidyl-Prolyl Isomerase Pin1-Mediated Abrogation of the Androgen Receptor-{beta}-Catenin Interaction
Mol. Cell. Biol., February 1, 2006; 26(3): 929 - 939.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
D. J. Mulholland, S. Dedhar, G. A. Coetzee, and C. C. Nelson
Interaction of Nuclear Receptors with the Wnt/{beta}-Catenin/Tcf Signaling Axis: Wnt You Like to Know?
Endocr. Rev., December 1, 2005; 26(7): 898 - 915.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. S. Joesting, S. Perrin, B. Elenbaas, S. E. Fawell, J. S. Rubin, O. E. Franco, S. W. Hayward, G. R. Cunha, and P. C. Marker
Identification of SFRP1 as a Candidate Mediator of Stromal-to-Epithelial Signaling in Prostate Cancer
Cancer Res., November 15, 2005; 65(22): 10423 - 10430.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L.-N. Song and E. P. Gelmann
Interaction of {beta}-Catenin and TIF2/GRIP1 in Transcriptional Activation by the Androgen Receptor
J. Biol. Chem., November 11, 2005; 280(45): 37853 - 37867.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
X. Yang, M.-W. Chen, S. Terry, F. Vacherot, D. K. Chopin, D. L. Bemis, J. Kitajewski, M. C. Benson, Y. Guo, and R. Buttyan
A Human- and Male-Specific Protocadherin that Acts through the Wnt Signaling Pathway to Induce Neuroendocrine Transdifferentiation of Prostate Cancer Cells
Cancer Res., June 15, 2005; 65(12): 5263 - 5271.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. A. Shedden, M. P. Kshirsagar, D. R. Schwartz, R. Wu, H. Yu, D. E. Misek, S. Hanash, H. Katabuchi, L. H. Ellenson, E. R. Fearon, et al.
Histologic Type, Organ of Origin, and Wnt Pathway Status: Effect on Gene Expression in Ovarian and Uterine Carcinomas
Clin. Cancer Res., March 15, 2005; 11(6): 2123 - 2131.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Verras, J. Brown, X. Li, R. Nusse, and Z. Sun
Wnt3a Growth Factor Induces Androgen Receptor-Mediated Transcription and Enhances Cell Growth in Human Prostate Cancer Cells
Cancer Res., December 15, 2004; 64(24): 8860 - 8866.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Mutoh, S. Sakurai, K. Satoh, K. Tamada, H. Kita, H. Osawa, T. Tomiyama, Y. Sato, H. Yamamoto, N. Isoda, et al.
Development of Gastric Carcinoma from Intestinal Metaplasia in Cdx2-transgenic Mice
Cancer Res., November 1, 2004; 64(21): 7740 - 7747.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Zhu, M. Mazor, Y. Kawano, M. M. Walker, H. Y. Leung, K. Armstrong, J. Waxman, and R. M. Kypta
Analysis of Wnt Gene Expression in Prostate Cancer: Mutual Inhibition by WNT11 and the Androgen Receptor
Cancer Res., November 1, 2004; 64(21): 7918 - 7926.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Rios-Doria, R. Kuefer, S. P. Ethier, and M. L. Day
Cleavage of {beta}-Catenin by Calpain in Prostate and Mammary Tumor Cells
Cancer Res., October 15, 2004; 64(20): 7237 - 7240.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
D. Masiello, S.-Y. Chen, Y. Xu, M. C. Verhoeven, E. Choi, A. N. Hollenberg, and S. P. Balk
Recruitment of {beta}-Catenin by Wild-Type or Mutant Androgen Receptors Correlates with Ligand-Stimulated Growth of Prostate Cancer Cells
Mol. Endocrinol., October 1, 2004; 18(10): 2388 - 2401.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. S. Park, S. I. Kim, M. S. Lee, C.-y. Youn, D. J. Kim, E.-h. Jho, and W. K. Song
Modulation of {beta}-Catenin Phosphorylation/Degradation by Cyclin-dependent Kinase 2
J. Biol. Chem., May 7, 2004; 279(19): 19592 - 19599.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. A. Heinlein and C. Chang
Androgen Receptor in Prostate Cancer
Endocr. Rev., April 1, 2004; 25(2): 276 - 308.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. R. Chesire, T. A. Dunn, C. M. Ewing, J. Luo, and W. B. Isaacs
Identification of Aryl Hydrocarbon Receptor as a Putative Wnt/{beta}-Catenin Pathway Target Gene in Prostate Cancer Cells
Cancer Res., April 1, 2004; 64(7): 2523 - 2533.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Rahman, H. Miyamoto, and C. Chang
Androgen Receptor Coregulators in Prostate Cancer: Mechanisms and Clinical Implications
Clin. Cancer Res., April 1, 2004; 10(7): 2208 - 2219.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. J. Linja, K. P. Porkka, Z. Kang, K. J. Savinainen, O. A. Janne, T. L. J. Tammela, R. L. Vessella, J. J. Palvimo, and T. Visakorpi
Expression of Androgen Receptor Coregulators in Prostate Cancer
Clin. Cancer Res., February 1, 2004; 10(3): 1032 - 1040.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. G. Horvath, S. M. Henshall, J. G. Kench, D. N. Saunders, C.-S. Lee, D. Golovsky, P. C. Brenner, G. F. O'Neill, R. Kooner, P. D. Stricker, et al.
Membranous Expression of Secreted Frizzled-Related Protein 4 Predicts for Good Prognosis in Localized Prostate Cancer and Inhibits PC3 Cellular Proliferation in Vitro
Clin. Cancer Res., January 15, 2004; 10(2): 615 - 625.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C. Doglioni, S. Piccinin, S. Demontis, M. G. Cangi, L. Pecciarini, C. Chiarelli, M. Armellin, T. Vukosavljevic, M. Boiocchi, and R. Maestro
Alterations of {beta}-Catenin Pathway in Non-Melanoma Skin Tumors: Loss of {alpha}-ABC Nuclear Reactivity Correlates with the Presence of {beta}-Catenin Gene Mutation
Am. J. Pathol., December 1, 2003; 163(6): 2277 - 2287.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
T. R. Salas, S. A. Reddy, J. L. Clifford, R. J. Davis, A. Kikuchi, S. M. Lippman, and D. G. Menter
Alleviating the Suppression of Glycogen Synthase Kinase-3{beta} by Akt Leads to the Phosphorylation of cAMP-response Element-binding Protein and Its Transactivation in Intact Cell Nuclei
J. Biol. Chem., October 17, 2003; 278(42): 41338 - 41346.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
W. W. J. de Leng, A. M. Westerman, M. A. J. Weterman, F. W. M. de Rooij, H. v. Dekken, A. F. P. M. de Goeij, S. B. Gruber, J. H. P. Wilson, G. J. A. Offerhaus, F. M. Giardiello, et al.
Cyclooxygenase 2 Expression and Molecular Alterations in Peutz-Jeghers Hamartomas and Carcinomas
Clin. Cancer Res., August 1, 2003; 9(8): 3065 - 3072.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. R. Schwartz, R. Wu, S. L. R. Kardia, A. M. Levin, C.-C. Huang, K. A. Shedden, R. Kuick, D. E. Misek, S. M. Hanash, J. M. G. Taylor, et al.
Novel Candidate Targets of {beta}-Catenin/T-cell Factor Signaling Identified by Gene Expression Profiling of Ovarian Endometrioid Adenocarcinomas
Cancer Res., June 1, 2003; 63(11): 2913 - 2922.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. de la Taille, M. A. Rubin, M.-W. Chen, F. Vacherot, S. G.-D. de Medina, M. Burchardt, R. Buttyan, and D. Chopin
{beta}-Catenin-related Anomalies in Apoptosis-resistant and Hormone-refractory Prostate Cancer Cells
Clin. Cancer Res., May 1, 2003; 9(5): 1801 - 1807.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Takahashi-Yanaga, Y. Taba, Y. Miwa, Y. Kubohara, Y. Watanabe, M. Hirata, S. Morimoto, and T. Sasaguri
Dictyostelium Differentiation-inducing Factor-3 Activates Glycogen Synthase Kinase-3beta and Degrades Cyclin D1 in Mammalian Cells
J. Biol. Chem., March 7, 2003; 278(11): 9663 - 9670.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L.-N. Song, R. Herrell, S. Byers, S. Shah, E. M. Wilson, and E. P. Gelmann
{beta}-Catenin Binds to the Activation Function 2 Region of the Androgen Receptor and Modulates the Effects of the N-Terminal Domain and TIF2 on Ligand-Dependent Transcription
Mol. Cell. Biol., March 1, 2003; 23(5): 1674 - 1687.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
P. M. Campbell and M. Szyf
Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway
Carcinogenesis, January 1, 2003; 24(1): 17 - 24.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Sharma, W. W. Chuang, and Z. Sun
Phosphatidylinositol 3-Kinase/Akt Stimulates Androgen Pathway through GSK3beta Inhibition and Nuclear beta -Catenin Accumulation
J. Biol. Chem., August 16, 2002; 277(34): 30935 - 30941.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. E. Pawlowski, J. R. Ertel, M. P. Allen, M. Xu, C. Butler, E. M. Wilson, and M. E. Wierman
Liganded Androgen Receptor Interaction with beta -Catenin. NUCLEAR CO-LOCALIZATION AND MODULATION OF TRANSCRIPTIONAL ACTIVITY IN NEURONAL CELLS
J. Biol. Chem., May 31, 2002; 277(23): 20702 - 20710.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. A. Heinlein and C. Chang
Androgen Receptor (AR) Coregulators: An Overview
Endocr. Rev., April 1, 2002; 23(2): 175 - 200.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pathol.Home page
R J Campbell and M Pignatelli
Molecular histology in the study of solid tumours
Mol. Pathol., April 1, 2002; 55(2): 80 - 82.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Zhai, R. Wu, D. R. Schwartz, D. Darrah, H. Reed, F. T. Kolligs, M. T. Nieman, E. R. Fearon, and K. R. Cho
Role of {beta}-Catenin/T-Cell Factor-Regulated Genes in Ovarian Endometrioid Adenocarcinomas
Am. J. Pathol., April 1, 2002; 160(4): 1229 - 1238.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Yang, X. Li, M. Sharma, C. Y. Sasaki, D. L. Longo, B. Lim, and Z. Sun
Linking beta -Catenin to Androgen-signaling Pathway
J. Biol. Chem., March 22, 2002; 277(13): 11336 - 11344.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. G. Chung, E. Provost, E. P. Kielhorn, L. A. Charette, B. L. Smith, and D. L. Rimm
Tissue Microarray Analysis of {beta}-Catenin in Colorectal Cancer Shows Nuclear Phospho-{beta}-catenin Is Associated with a Better Prognosis
Clin. Cancer Res., December 1, 2001; 7(12): 4013 - 4020.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Wu, Y. Zhai, E. R. Fearon, and K. R. Cho
Diverse Mechanisms of {beta}-Catenin Deregulation in Ovarian Endometrioid Adenocarcinomas
Cancer Res., November 1, 2001; 61(22): 8247 - 8255.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
E. Sadot, B. Geiger, M. Oren, and A. Ben-Ze'ev
Down-Regulation of {beta}-Catenin by Activated p53
Mol. Cell. Biol., October 15, 2001; 21(20): 6768 - 6781.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
S. Persad, A. A.Troussard, T. R. McPhee, D. J. Mulholland, and S. Dedhar
Tumor Suppressor PTEN Inhibits Nuclear Accumulation of {beta}-Catenin and T Cell/Lymphoid Enhancer Factor 1-mediated Transcriptional Activation
J. Cell Biol., June 4, 2001; 153(6): 1161 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R.-H. Chen and F. McCormick
Selective Targeting to the Hyperactive {beta}-Catenin/T-Cell Factor Pathway in Colon Cancer Cells
Cancer Res., June 1, 2001; 61(11): 4445 - 4449.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Takayasu, H. Horie, E. Hiyama, T. Matsunaga, Y. Hayashi, Y. Watanabe, S. Suita, M. Kaneko, F. Sasaki, K. Hashizume, et al.
Frequent Deletions and Mutations of the {beta}-Catenin Gene Are Associated with Overexpression of Cyclin D1 and Fibronectin and Poorly Differentiated Histology in Childhood Hepatoblastoma
Clin. Cancer Res., April 1, 2001; 7(4): 901 - 908.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
S. C. Abraham, B. Nobukawa, F. M. Giardiello, S. R. Hamilton, and T.-T. Wu
Sporadic Fundic Gland Polyps : Common Gastric Polyps Arising Through Activating Mutations in the {beta}-Catenin Gene
Am. J. Pathol., March 1, 2001; 158(3): 1005 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. C. Abraham, E. A. Montgomery, F. M. Giardiello, and T.-T. Wu
Frequent {beta}-Catenin Mutations in Juvenile Nasopharyngeal Angiofibromas
Am. J. Pathol., March 1, 2001; 158(3): 1073 - 1078.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Fujita, Y. Furukawa, Y. Nagasawa, M. Ogawa, and Y. Nakamura
Down-Regulation of Monocyte Chemotactic Protein-3 by Activated {beta}-Catenin
Cancer Res., December 1, 2000; 60(23): 6683 - 6687.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
S. Maiti, R. Alam, C. I. Amos, and V. Huff
Frequent Association of {beta}-Catenin and WT1 Mutations in Wilms Tumors
Cancer Res., November 1, 2000; 60(22): 6288 - 6292.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
M. Miyaki, T. Iijima, K. Hosono, R. Ishii, M. Yasuno, T. Mori, M. Toi, T. Hishima, N. Shitara, K. Tamura, et al.
Somatic Mutations of LKB1 and {beta}-Catenin Genes in Gastrointestinal Polyps from Patients with Peutz-Jeghers Syndrome
Cancer Res., November 1, 2000; 60(22): 6311 - 6313.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
C. I. Truica, S. Byers, and E. P. Gelmann
{beta}-Catenin Affects Androgen Receptor Transcriptional Activity and Ligand Specificity
Cancer Res., September 1, 2000; 60(17): 4709 - 4713.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
H.-C. Hsu, Y.-M. Jeng, T.-L. Mao, J.-S. Chu, P.-L. Lai, and S.-Y. Peng
{beta}-Catenin Mutations Are Associated with a Subset of Low-Stage Hepatocellular Carcinoma Negative for Hepatitis B Virus and with Favorable Prognosis
Am. J. Pathol., September 1, 2000; 157(3): 763 - 770.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Schneider, S. Borgnat, H. Lang, O. Régine, V. Lindner, M. Kassem, C. Saussine, P. Oudet, D. Jacqmin, and M. P. Gaub
Evaluation of Microsatellite Analysis in Urine Sediment for Diagnosis of Bladder Cancer
Cancer Res., August 1, 2000; 60(16): 4617 - 4622.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
P. Polakis
Wnt signaling and cancer
Genes & Dev., August 1, 2000; 14(15): 1837 - 1851.
[Full Text]

Home page
 CarcinogenesisHome page
M. Takahashi, M. Mutoh, T. Kawamori, T. Sugimura, and K. Wakabayashi
Altered expression of {beta}-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis
Carcinogenesis, July 1, 2000; 21(7): 1319 - 1327.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Zhurinsky, M. Shtutman, and A. Ben-Ze'ev
Differential Mechanisms of LEF/TCF Family-Dependent Transcriptional Activation by beta -Catenin and Plakoglobin
Mol. Cell. Biol., June 15, 2000; 20(12): 4238 - 4252.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
F. T. Kolligs, B. Kolligs, K. M. Hajra, G. Hu, M. Tani, K. R. Cho, and E. R. Fearon
gamma -Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta -catenin
Genes & Dev., June 1, 2000; 14(11): 1319 - 1331.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
I.-M. Shih, J. Yu, T.-C. He, B. Vogelstein, and K. W. Kinzler
The {beta}-Catenin Binding Domain of Adenomatous Polyposis Coli Is Sufficient for Tumor Suppression
Cancer Res., March 1, 2000; 60(6): 1671 - 1676.
[Abstract] [Full Text]

Home page
 Clin. Cancer Res.Home page
V. Bilim, T. Kawasaki, A. Katagiri, S.-j. Wakatsuki, K. Takahashi, and Y. Tomita
Altered Expression of {beta}-Catenin in Renal Cell Cancer and Transitional Cell Cancer with the Absence of {beta}-catenin Gene Mutations
Clin. Cancer Res., February 1, 2000; 6(2): 460 - 466.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
H. Huang, B. M. Mahler-Araujo, A. Sankila, L. Chimelli, Y. Yonekawa, P. Kleihues, and H. Ohgaki
APC Mutations in Sporadic Medulloblastomas
Am. J. Pathol., February 1, 2000; 156(2): 433 - 437.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Huang, H. Fujii, A. Sankila, B. M. Mahler-Araujo, M. Matsuda, G. Cathomas, and H. Ohgaki
{beta}-Catenin Mutations Are Frequent in Human Hepatocellular Carcinomas Associated with Hepatitis C Virus Infection
Am. J. Pathol., December 1, 1999; 155(6): 1795 - 1801.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Hattori, S. Hatakeyama, M. Shirane, M. Matsumoto, and K.-i. Nakayama
Molecular Dissection of the Interactions among Ikappa Balpha , FWD1, and Skp1 Required for Ubiquitin-mediated Proteolysis of Ikappa Balpha
J. Biol. Chem., October 15, 1999; 274(42): 29641 - 29647.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. W. Klymkowsky, B. O. Williams, G. D. Barish, H. E. Varmus, and Y. E. Vourgourakis
Membrane-anchored Plakoglobins Have Multiple Mechanisms of Action in Wnt Signaling
Mol. Biol. Cell, October 1, 1999; 10(10): 3151 - 3169.
[Abstract] [Full Text]

Home page
 J. Cell Biol.Home page
J. Espada, M. Perez-Moreno, V. M.M. Braga, P. Rodriguez-Viciana, and A. Cano
H-Ras Activation Promotes Cytoplasmic Accumulation and Phosphoinositide 3-OH Kinase Association of {beta}-Catenin in Epidermal Keratinocytes
J. Cell Biol., September 6, 1999; 146(5): 967 - 980.