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Induces Cell Growth Inhibition by Fas-mediated Apoptosis: Requirement of STAT1 Protein for Up-Regulation of Fas and FasL Expression1Departments of General Surgery [X. X., A. S-F. C.], Medicine [J. P.], and Immunology/Microbiology [J. P., A. S-F. C.], Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, and Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 05620-8023 [X-Y. F.]
The mechanism by which IFN-
inhibits tumor cell growth has not been fully understood. Here we report that IFN- up-regulated the expression of Fas and Fas ligand (FasL) on HT29 cells, a human colon adenocarcinoma cell line, and subsequently induced apoptosis of these cells. The kinetics of cell death in IFN--treated HT29 cells paralleled the increase in the levels of Fas and FasL expression. We further show that IFN- up-regulated the expression of Fas and FasL in STAT1-transfected U3A cells but not in STAT1-deficient U3A cells. Correspondingly, IFN- induced cell death in STAT1-transfected U3A cells but not in STAT1-deficient U3A cells. IFN--induced cell death was inhibited by caspase-1 inhibitors. Our results suggest that cell growth inhibition by IFN- is due to apoptosis mediated by Fas and FasL interaction.
1 This work was supported by grants from American Cancer Society (Illinois Division, 97-24), American Cancer Society (Institutional), and Rush University Research Council (to X. X.).
2 To whom requests for reprints should be addressed, at Department of General Surgery, Rush-Presbyterian-St. Luke's Medical Center, 1653 West Congress Parkway, Chicago, IL 60612; Phone: (312) 942-5000, extension 21368; Fax: (312) 942-2867; E-mail: xxu@rush.edu.
Received 10/ 6/97. Accepted 2/25/98.
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|
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|
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|
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|
|
|
|
|
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|
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|
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|
|
|
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|
|
|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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