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Department of Medicine, Division of Gastroenterology [K. T. W., S. F., K. S. R., S. J. M.], Greenebaum Cancer Center [K. T. W., S. J. M.], Graduate Program in Molecular and Cell Biology [S. J. M.], and Department of Pathology [S. J. M.], University of Maryland School of Medicine and Baltimore Veterans Affairs Maryland Health Care System, Baltimore, Maryland 21201
Barrett's esophagus is a premalignant condition arising in response to chronic reflux esophagitis. Inducible nitric oxide synthase (iNOS; NOS-2) and cyclooxygenase-2 (COX-2) are mediators of inflammation and regulators of epithelial cell growth. Expression levels of iNOS and COX-2 are high in colorectal adenomas and carcinomas, and COX-2 expression is elevated in gastric cancers. To determine the involvement of iNOS and COX-2 in Barrett's-associated neoplasia, we measured expression of these genes in metaplastic Barrett's and esophageal adenocarcinomas. We detected elevated iNOS and COX-2 mRNA levels in Barrett's mucosa compared with paired gastric control tissues in 16 of 21 (76%) and 17 of 21 (80%) patients, respectively (P < 0.001 for both genes). In esophageal adenocarcinomas, iNOS and COX-2 mRNA levels were increased in four of five and five of five cases, respectively. Furthermore, in 10 of 10 Barrett's patients, immunohistochemical staining for iNOS and COX-2 expression was strongly positive and higher than in matched gastric controls. Increased COX-2 expression was confirmed by Western blotting. These findings support the hypothesis that iNOS and COX-2 are involved early and often in Barrett's-associated neoplastic progression.
1 Supported by NIH Grants K08-DK02469, R01-CA67497, R01-DK47717, and R01-DK53620; the Robert and Sally D. Funderburg Award in Gastric Cancer Biology; the University of Maryland School of Medicine; and the Office of Medical Research, Department of Veterans Affairs.
2 To whom requests for reprints should be addressed, at Baltimore Veterans Affairs Medical Center, Room 5D-151, 10 North Greene Street, Baltimore, MD 21201. Phone: (410) 605-7000, ext. 5211; Fax: (410) 605-7914; E-mail: kwilson@umaryland.edu.
Received 4/ 3/98. Accepted 6/ 1/98.
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|
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|
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|
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|
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|
 |
|
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|
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|
|
 |
|
 D. Zhang, J. Li, L. Song, W. Ouyang, J. Gao, and C. Huang A JNK1/AP-1-Dependent, COX-2 Induction Is Implicated in 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Transformation through Regulating Cell Cycle Progression Mol. Cancer Res., January 1, 2008; 6(1): 165 - 174. [Abstract] [Full Text] [PDF]
|
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|
|
 |
|
 F Francois, J Roper, A J Goodman, Z Pei, M Ghumman, M Mourad, A Z O. de Perez, G I Perez-Perez, C-H Tseng, and M J Blaser The association of gastric leptin with oesophageal inflammation and metaplasia Gut, January 1, 2008; 57(1): 16 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Zagorowicz and J. Jankowski Molecular changes in the progression of Barrett's oesophagus Postgrad. Med. J., August 1, 2007; 83(982): 529 - 535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
 K. L. Wang, T.-T. Wu, E. Resetkova, H. Wang, A. M. Correa, W. L. Hofstetter, S. G. Swisher, J. A. Ajani, A. Rashid, S. R. Hamilton, et al. Expression of Annexin A1 in Esophageal and Esophagogastric Junction Adenocarcinomas: Association with Poor Outcome Clin. Cancer Res., August 1, 2006; 12(15): 4598 - 4604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
 D. Vallbohmer, J. H. Peters, H. Kuramochi, D. Oh, D. Yang, D. Shimizu, S. R. DeMeester, J. A. Hagen, P. T. Chandrasoma, K. D. Danenberg, et al. Molecular Determinants in Targeted Therapy for Esophageal Adenocarcinoma Arch Surg, May 1, 2006; 141(5): 476 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 R. F. Souza and S. J. Spechler Concepts in the Prevention of Adenocarcinoma of the Distal Esophagus and Proximal Stomach CA Cancer J Clin, November 1, 2005; 55(6): 334 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
D. T. McManus, A. Olaru, and S. J. Meltzer Biomarkers of Esophageal Adenocarcinoma and Barrett's Esophagus Cancer Res., March 1, 2004; 64(5): 1561 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. N. Tucker, A. J. Dannenberg, E. K. Yang, and T. J. Fahey III Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines Carcinogenesis, March 1, 2004; 25(3): 419 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T J Jang, S K Min, J D Bae, K H Jung, J I Lee, J R Kim, and W S Ahn Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett's metaplasia induced by duodenal contents reflux Gut, January 1, 2004; 53(1): 27 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Choy and L. Milas Enhancing Radiotherapy With Cyclooxygenase-2 Enzyme Inhibitors: A Rational Advance? J Natl Cancer Inst, October 1, 2003; 95(19): 1440 - 1452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-T. Kuo, K.-C. Chow, Y.-C. Wu, C.-S. Lin, H.-W. Wang, W.-Y. Li, and L.-S. Wang Clinicopathologic significance of cyclooxygenase-2 overexpression in esophageal squamous cell carcinoma Ann. Thorac. Surg., September 1, 2003; 76(3): 909 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
X. Chen, N. Li, S. Wang, N. Wu, J. Hong, X. Jiao, M. J. Krasna, D. G. Beer, and C. S. Yang Leukotriene A4 Hydrolase in Rat and Human Esophageal Adenocarcinomas and Inhibitory Effects of Bestatin J Natl Cancer Inst, July 16, 2003; 95(14): 1053 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. V. N. Lord, J. M. Park, K. Wickramasinghe, S. R. DeMeester, S. Oberg, D. Salonga, J. Singer, J. H. Peters, K. D. Danenberg, T. R. DeMeester, et al. Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus J. Thorac. Cardiovasc. Surg., February 1, 2003; 125(2): 246 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
X. Chen, N. Li, S. Wang, J. Hong, M. Fang, J. Yousselfson, P. Yang, R. A. Newman, R. A. Lubet, and C. S. Yang Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and {alpha}-difluoromethylornithine on tumorigenesis in a rat surgical model Carcinogenesis, December 1, 2002; 23(12): 2095 - 2102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sun, X. M. Tang, E. Half, M. T. Kuo, and F. A. Sinicrope Cyclooxygenase-2 Overexpression Reduces Apoptotic Susceptibility by Inhibiting the Cytochrome c-dependent Apoptotic Pathway in Human Colon Cancer Cells Cancer Res., November 1, 2002; 62(21): 6323 - 6328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Vaughan, A. R. Kristal, P. L. Blount, D. S. Levine, P. C. Galipeau, L. J. Prevo, C. A. Sanchez, P. S. Rabinovitch, and B. J. Reid Nonsteroidal Anti-inflammatory Drug Use, Body Mass Index, and Anthropometry in Relation to Genetic and Flow Cytometric Abnormalities in Barrett's Esophagus Cancer Epidemiol. Biomarkers Prev., August 1, 2002; 11(8): 745 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Carlton, R. Gopalakrishnan, A. Gupta, B. W. Liston, S. Habib, M. A. Morse, and G. D. Stoner Piroxicam Is an Ineffective Inhibitor of N-Nitrosomethylbenzylamine-induced Tumorigenesis in the Rat Esophagus Cancer Res., August 1, 2002; 62(15): 4376 - 4382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Gobert, Y. Cheng, J.-Y. Wang, J.-L. Boucher, R. K. Iyer, S. D. Cederbaum, R. A. Casero Jr., J. C. Newton, and K. T. Wilson Helicobacter pylori Induces Macrophage Apoptosis by Activation of Arginase II J. Immunol., May 1, 2002; 168(9): 4692 - 4700. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Gupta and R. N. DuBois Cyclooxygenase-2 Inhibitor Therapy for the Prevention of Esophageal Adenocarcinoma in Barrett's Esophagus J Natl Cancer Inst, March 20, 2002; 94(6): 406 - 407. [Full Text] [PDF]
|
|
|
|
|
|
N. S. Buttar, K. K. Wang, M. A. Anderson, R. A. Dierkhising, R. J. Pacifico, K. K. Krishnadath, and L. S. Lutzke The Effect of Selective Cyclooxygenase-2 Inhibition in Barrett's Esophagus Epithelium: An In Vitro Study J Natl Cancer Inst, March 20, 2002; 94(6): 422 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Phoa and B. Epe Influence of nitric oxide on the generation and repair of oxidative DNA damage in mammalian cells Carcinogenesis, March 1, 2002; 23(3): 469 - 475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Half, X. M. Tang, K. Gwyn, A. Sahin, K. Wathen, and F. A. Sinicrope Cyclooxygenase-2 Expression in Human Breast Cancers and Adjacent Ductal Carcinoma in Situ Cancer Res., March 1, 2002; 62(6): 1676 - 1681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Specht, O. N. Tucker, M. Hocever, D. Gonzalez, L. Teng, and T. J. Fahey III Cyclooxygenase-2 Expression in Thyroid Nodules J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 358 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Cao, K. B. Dave, T. P. Doan, and S. M. Prescott Fatty Acid CoA Ligase 4 Is Up-Regulated in Colon Adenocarcinoma Cancer Res., December 1, 2001; 61(23): 8429 - 8434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yoshimatsu, D. Golijanin, P. B. Paty, R. A. Soslow, P.-J. Jakobsson, R. A. DeLellis, K. Subbaramaiah, and A. J. Dannenberg Inducible Microsomal Prostaglandin E Synthase Is Overexpressed in Colorectal Adenomas and Cancer Clin. Cancer Res., December 1, 2001; 7(12): 3971 - 3976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Marrogi, M. A. Khan, H. E. van Gijssel, J. A. Welsh, H. Rahim, A. J. Demetris, K. V. Kowdley, S. P. Hussain, J. Nair, H. Bartsch, et al. Oxidative Stress and p53 Mutations in the Carcinogenesis of Iron Overload-Associated Hepatocellular Carcinoma J Natl Cancer Inst, November 7, 2001; 93(21): 1652 - 1655. [Full Text] [PDF]
|
|
|
|
|
|
K. Salmenkivi, C. Haglund, A. Ristimaki, J. Arola, and P. Heikkila Increased Expression of Cyclooxygenase-2 in Malignant Pheochromocytomas J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5615 - 5619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Klimp, H. Hollema, C. Kempinga, A. G. J. van der Zee, E. G. E. de Vries, and T. Daemen Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Human Ovarian Tumors and Tumor-associated Macrophages Cancer Res., October 1, 2001; 61(19): 7305 - 7309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Kobayashi, H. Miwa, S. Watanabe, M. Tsujii, R. N. Dubois, and N. Sato Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, September 1, 2001; 281(3): G688 - G696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yoshimatsu, N. K. Altorki, D. Golijanin, F. Zhang, P.-J. Jakobsson, A. J. Dannenberg, and K. Subbaramaiah Inducible Prostaglandin E Synthase Is Overexpressed in Non-Small Cell Lung Cancer Clin. Cancer Res., September 1, 2001; 7(9): 2669 - 2674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Chen and C. S. Yang Esophageal adenocarcinoma: a review and perspectives on the mechanism of carcinogenesis and chemoprevention Carcinogenesis, August 1, 2001; 22(8): 1119 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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