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Identification of a Consistent Region of Allelic Loss on 1p32 in Meningiomas: Correlation with Increased Morbidity¹

Divisions of Oncology [E. P. S., P. S. W., J. M. M., G. M. B.] and Biostatistics and Epidemiology [H. Z., A. C.], Children's Hospital of Philadelphia, and Department of Pediatrics [J. M. M., A. C., G. M. B.], University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; and Departments of Neurosurgery [T. M.] and Clinical Genetics [J. P. D., C. B.], Karolinska Hospital, S-104 01 Stockholm, Sweden

Meningioma is a common tumor of the central nervous system. Deletions of the short arm of chromsome 1 (1p) are the second most commonly observed chromosomal abnormality in these tumors. Here, we analyzed tumor and normal DNAs from 157 meningioma patients using PCR-based polymorphic loci. Loss of heterozygosity (LOH) for at least one informative marker on 1p was observed in 54 cases (34%), whereas LOH on 1q occurred in only 9 cases (8%). High-resolution deletion mapping defined a consensus region of deletion flanked distally by D1S2713 and proximally by D1S2134, which spans 1.5 cM within 1p32. LOH in this region has also been observed in several other malignancies, suggesting the presence of a tumor suppressor gene or genes that are important for several types of cancer. Statistical analysis revealed that 1p LOH was associated with chromosome 22 deletions and with abnormalities of the NF2 gene in meningioma. In addition, unlike other clinical and molecular characteristics, only 1p LOH was shown to be significantly associated with recurrence-free survival.

¹ This work was supported by NIH Grants CA-39771 and 5U10-CA15488-23, the Audrey E. Evans Endowed Chair, the Swedish Cancer Society, and the Swedish Medical Research Council.

² To whom requests for reprints should be addressed, at Division of Oncology, Children's Hospital of Philadelphia, Room 902D, Abramson Research Center, 324 South 34th Street, Philadelphia, PA 19104-4318. Phone: (215) 590-2817; Fax: (215) 590-3770; E-mail: brodeur@email.chop.edu.

Received 3/ 2/98. Accepted 6/16/98.

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