Cancer Research Cancer Epigenetics Protein Translation and Cancer
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 58, 3237-3242, August 1, 1998]
© 1998 American Association for Cancer Research
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tomlinson, G. E.
Right arrow Articles by Gazdar, A. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tomlinson, G. E.
Right arrow Articles by Gazdar, A. F.

Characterization of a Breast Cancer Cell Line Derived from a Germ-Line BRCA1 Mutation Carrier1

Gail E. Tomlinson2, Tina T-L. Chen, Victor A. Stastny, Arvind K. Virmani, Monique A. Spillman, Vijay Tonk, Joanne L. Blum, Nancy R. Schneider, Ignacio I. Wistuba, Jerry W. Shay, John D. Minna and Adi F. Gazdar

Departments of Pediatrics [G. E. T.], Pathology [A. K. V., I. I. W., A. F. G.], and Internal Medicine and Pharmacology [J. D. M.] and the Hamon Center for Therapeutic Oncology Research [G. E. T., T. T-L. C., V. A. S., A. K. V., I. I. W., J. D. M., A. F. G.], Southwestern Medical School [M. A. S.], Departments of Cell Biology and Neurosciences [J. W. S.] and Pathology [N. R. S.], University of Texas Southwestern Medical Center, Dallas, Texas 75235; Texas Tech University, Lubbock, Texas 79430 [V. T.]; and Baylor University Medical Center, Dallas, Texas 75246 [J. L. B.]

A tumor cell line, HCC1937, was established from a primary breast carcinoma from a 24-year-old patient with a germ-line BRCA1 mutation. A corresponding B-lymphoblastoid cell line was established from the patient's peripheral blood lymphocytes. BRCA1 analysis revealed that the tumor cell line is homozygous for the BRCA1 5382insC mutation, whereas the patient's lymphocyte DNA is heterozygous for the same mutation, as are at least two other family members' lymphocyte DNA. The tumor cell line is marked by multiple additional genetic changes including a high degree of aneuploidy, an acquired mutation of TP53 with wild-type allele loss, an acquired homozygous deletion of the PTEN gene, and loss of heterozygosity at multiple loci known to be involved in the pathogenesis of breast cancer. Comparison of the primary tumor with the cell line revealed the same BRCA1 mutation and an identical pattern of allele loss at multiple loci, indicating that the cell line had maintained many of the properties of the original tumor. This breast tumor-derived cell line may provide a useful model system for the study of familial breast cancer pathogenesis and for elucidating BRCA1 function and localization.

1 Supported by Grants NCI CA70472-03 (to G. E. T.), DAMD 17-96-1-6206 (to G. E. T.), and DAMD 17-94-J-0477 (to J. W. S. and A. F. G.) and the Susan G. Komen Foundation (to G. E. T., J. L. B., J. W. S., and J. D. M.) and Clay Weed Memorial Fund (to G. E. T.).

2 To whom requests for reprints should be addressed, at Department of Pediatrics and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235-8593. Phone: (214) 648-4907/4903; Fax: (214) 648-4940; E-mail: tomlinson@simmons.swmed.edu.

Received 5/21/98. Accepted 6/16/98.




This article has been cited by other articles:


Home page
 Cancer Res.Home page
S. Fan, Q. Meng, T. Saha, F. H. Sarkar, and E. M. Rosen
Low Concentrations of Diindolylmethane, a Metabolite of Indole-3-Carbinol, Protect against Oxidative Stress in a BRCA1-Dependent Manner
Cancer Res., August 1, 2009; 69(15): 6083 - 6091.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
F. Zhang, Q. Fan, K. Ren, and P. R. Andreassen
PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2
Mol. Cancer Res., July 1, 2009; 7(7): 1110 - 1118.
[Abstract] [Full Text] [PDF]

Home page
 Endocr Relat CancerHome page
A. Shukla, J. Grisouard, V. Ehemann, A. Hermani, H. Enzmann, and D. Mayer
Analysis of signaling pathways related to cell proliferation stimulated by insulin analogs in human mammary epithelial cell lines
Endocr. Relat. Cancer, June 1, 2009; 16(2): 429 - 441.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. Alli, V. B. Sharma, P. Sunderesakumar, and J. M. Ford
Defective Repair of Oxidative DNA Damage in Triple-Negative Breast Cancer Confers Sensitivity to Inhibition of Poly(ADP-Ribose) Polymerase
Cancer Res., April 15, 2009; 69(8): 3589 - 3596.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Yan, C. P. Black, P. T. Cao, J. L. Haferbier, R. H. Kolb, R. S. Spieker, A. M. Ristow, and K. H. Cowan
{gamma}-Irradiation-Induced DNA Damage Checkpoint Activation Involves Feedback Regulation between Extracellular Signal-Regulated Kinase 1/2 and BRCA1
Cancer Res., July 1, 2008; 68(13): 5113 - 5121.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Pavelitz, A. D. Bailey, C. P. Elco, and A. M. Weiner
Human U2 snRNA Genes Exhibit a Persistently Open Transcriptional State and Promoter Disassembly at Metaphase
Mol. Cell. Biol., June 1, 2008; 28(11): 3573 - 3588.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. M. Hosey, J. J. Gorski, M. M. Murray, J. E. Quinn, W. Y. Chung, G. E. Stewart, C. R. James, S. M. Farragher, J. M. Mulligan, A. N. Scott, et al.
Molecular Basis for Estrogen Receptor {alpha} Deficiency in BRCA1-Linked Breast Cancer
J Natl Cancer Inst, November 21, 2007; 99(22): 1683 - 1694.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
V. C. Jordan
Estrogen Receptors in BRCA1-Mutant Breast Cancer: Now You See Them, Now You Don't
J Natl Cancer Inst, November 21, 2007; 99(22): 1655 - 1657.
[Full Text] [PDF]

Home page
 BloodHome page
R. Gupta, S. Sharma, J. A. Sommers, M. K. Kenny, S. B. Cantor, and R. M. Brosh Jr
FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein
Blood, October 1, 2007; 110(7): 2390 - 2398.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. D. Treszezamsky, L. A. Kachnic, Z. Feng, J. Zhang, C. Tokadjian, and S. N. Powell
BRCA1- and BRCA2-Deficient Cells Are Sensitive to Etoposide-Induced DNA Double-Strand Breaks via Topoisomerase II
Cancer Res., August 1, 2007; 67(15): 7078 - 7081.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Yamane, J. E. Schupp, and T. J. Kinsella
BRCA1 Activates a G2-M Cell Cycle Checkpoint following 6-Thioguanine-Induced DNA Mismatch Damage
Cancer Res., July 1, 2007; 67(13): 6286 - 6292.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
T. Wiltshire, J. Senft, Y. Wang, G. W. Konat, S. L. Wenger, E. Reed, and W. Wang
BRCA1 Contributes to Cell Cycle Arrest and Chemoresistance in Response to the Anticancer Agent Irofulven
Mol. Pharmacol., April 1, 2007; 71(4): 1051 - 1060.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
A. Hollestelle, F. Elstrodt, J. H.A. Nagel, W. W. Kallemeijn, and M. Schutte
Phosphatidylinositol-3-OH Kinase or RAS Pathway Mutations in Human Breast Cancer Cell Lines
Mol. Cancer Res., February 1, 2007; 5(2): 195 - 201.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
C. DelloRusso, P. L. Welcsh, W. Wang, R. L. Garcia, M.-C. King, and E. M. Swisher
Functional Characterization of a Novel BRCA1-Null Ovarian Cancer Cell Line in Response to Ionizing Radiation
Mol. Cancer Res., January 1, 2007; 5(1): 35 - 45.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
X. Yu, S. Fu, M. Lai, R. Baer, and J. Chen
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP.
Genes & Dev., July 1, 2006; 20(13): 1721 - 1726.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
W. Zhu and A. Dutta
An ATR- and BRCA1-Mediated Fanconi Anemia Pathway Is Required for Activating the G2/M Checkpoint and DNA Damage Repair upon Rereplication
Mol. Cell. Biol., June 15, 2006; 26(12): 4601 - 4611.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
R. I. Yarden and M. Z. Papa
BRCA1 at the crossroad of multiple cellular pathways: approaches for therapeutic interventions.
Mol. Cancer Ther., June 1, 2006; 5(6): 1396 - 1404.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. P. Schlegel, F. M. Jodelka, and R. Nunez
BRCA1 Promotes Induction of ssDNA by Ionizing Radiation.
Cancer Res., May 15, 2006; 66(10): 5181 - 5189.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H.-S. Kim, H. Li, M. Cevher, A. Parmelee, D. Fonseca, F. E. Kleiman, and S. B. Lee
DNA Damage-Induced BARD1 Phosphorylation Is Critical for the Inhibition of Messenger RNA Processing by BRCA1/BARD1 Complex.
Cancer Res., May 1, 2006; 66(9): 4561 - 4565.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
C.-X. Deng
BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution
Nucleic Acids Res., March 6, 2006; 34(5): 1416 - 1426.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. A. Piantadosi and H. B. Suliman
Mitochondrial Transcription Factor A Induction by Redox Activation of Nuclear Respiratory Factor 1
J. Biol. Chem., January 6, 2006; 281(1): 324 - 333.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
F. Elstrodt, A. Hollestelle, J. H.A. Nagel, M. Gorin, M. Wasielewski, A. van den Ouweland, S. D. Merajver, S. P. Ethier, and M. Schutte
BRCA1 Mutation Analysis of 41 Human Breast Cancer Cell Lines Reveals Three New Deleterious Mutants
Cancer Res., January 1, 2006; 66(1): 41 - 45.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Wei, T. A. Grushko, J. Dignam, F. Hagos, R. Nanda, L. Sveen, J. Xu, J. Fackenthal, M. Tretiakova, S. Das, et al.
BRCA1 Promoter Methylation in Sporadic Breast Cancer Is Associated with Reduced BRCA1 Copy Number and Chromosome 17 Aneusomy
Cancer Res., December 1, 2005; 65(23): 10692 - 10699.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. D. Choudhury, H. Xu, A. P. Modi, W. Zhang, T. Ludwig, and R. Baer
Hyperphosphorylation of the BARD1 Tumor Suppressor in Mitotic Cells
J. Biol. Chem., July 1, 2005; 280(26): 24669 - 24679.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Furuta, X. Jiang, B. Gu, E. Cheng, P.-L. Chen, and W.-H. Lee
Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells
PNAS, June 28, 2005; 102(26): 9176 - 9181.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. R. Alt, A. Bouska, M. R. Fernandez, R. L. Cerny, H. Xiao, and C. M. Eischen
Mdm2 Binds to Nbs1 at Sites of DNA Damage and Regulates Double Strand Break Repair
J. Biol. Chem., May 13, 2005; 280(19): 18771 - 18781.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. M. Sirchia, L. Ramoscelli, F. R. Grati, F. Barbera, D. Coradini, F. Rossella, G. Porta, E. Lesma, A. Ruggeri, P. Radice, et al.
Loss of the Inactive X Chromosome and Replication of the Active X in BRCA1-Defective and Wild-type Breast Cancer Cells
Cancer Res., March 15, 2005; 65(6): 2139 - 2146.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W. W. Y. Au and B. R. Henderson
The BRCA1 RING and BRCT Domains Cooperate in Targeting BRCA1 to Ionizing Radiation-induced Nuclear Foci
J. Biol. Chem., February 25, 2005; 280(8): 6993 - 7001.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. Taron, R. Rosell, E. Felip, P. Mendez, J. Souglakos, M. S. Ronco, C. Queralt, J. Majo, J. M. Sanchez, J. J. Sanchez, et al.
BRCA1 mRNA expression levels as an indicator of chemoresistance in lung cancer
Hum. Mol. Genet., October 1, 2004; 13(20): 2443 - 2449.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. F. Arlt, B. Xu, S. G. Durkin, A. M. Casper, M. B. Kastan, and T. W. Glover
BRCA1 Is Required for Common-Fragile-Site Stability via Its G2/M Checkpoint Function
Mol. Cell. Biol., August 1, 2004; 24(15): 6701 - 6709.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Fabbro, K. Savage, K. Hobson, A. J. Deans, S. N. Powell, G. A. McArthur, and K. K. Khanna
BRCA1-BARD1 Complexes Are Required for p53Ser-15 Phosphorylation and a G1/S Arrest following Ionizing Radiation-induced DNA Damage
J. Biol. Chem., July 23, 2004; 279(30): 31251 - 31258.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. Razandi, A. Pedram, E. M. Rosen, and E. R. Levin
BRCA1 Inhibits Membrane Estrogen and Growth Factor Receptor Signaling to Cell Proliferation in Breast Cancer
Mol. Cell. Biol., July 1, 2004; 24(13): 5900 - 5913.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Zhang, H. Willers, Z. Feng, J. C. Ghosh, S. Kim, D. T. Weaver, J. H. Chung, S. N. Powell, and F. Xia
Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair
Mol. Cell. Biol., January 15, 2004; 24(2): 708 - 718.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
S. Toth-Fejel, J. Cheek, K. Calhoun, P. Muller, and R. F. Pommier
Estrogen and Androgen Receptors as Comediators of Breast Cancer Cell Proliferation: Providing a New Therapeutic Tool
Arch Surg, January 1, 2004; 139(1): 50 - 54.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. A. Krum, G. A. Miranda, C. Lin, and T. F. Lane
BRCA1 Associates with Processive RNA Polymerase II
J. Biol. Chem., December 26, 2003; 278(52): 52012 - 52020.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Xiong, S. Fan, Q. Meng, L. Schramm, C. Wang, B. Bouzahza, J. Zhou, B. Zafonte, I. D. Goldberg, B. R. Haddad, et al.
BRCA1 Inhibition of Telomerase Activity in Cultured Cells
Mol. Cell. Biol., December 1, 2003; 23(23): 8668 - 8690.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Yun and W.-H. Lee
Degradation of Transcription Repressor ZBRK1 through the Ubiquitin-Proteasome Pathway Relieves Repression of Gadd45a upon DNA Damage
Mol. Cell. Biol., October 15, 2003; 23(20): 7305 - 7314.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. E. Quinn, R. D. Kennedy, P. B. Mullan, P. M. Gilmore, M. Carty, P. G. Johnston, D. P. Harkin, U. Benatti, L. C. Boffa, and M. Ferrarini
BRCA1 Functions as a Differential Modulator of Chemotherapy-induced Apoptosis
Cancer Res., October 1, 2003; 63(19): 6221 - 6228.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Spiro and C. T. McMurray
Nuclease-Deficient FEN-1 Blocks Rad51/BRCA1-Mediated Repair and Causes Trinucleotide Repeat Instability
Mol. Cell. Biol., September 1, 2003; 23(17): 6063 - 6074.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
S. L. Starcevic, N. M. Diotte, K. L. Zukowski, M. J. Cameron, and R. F. Novak
Oxidative DNA Damage and Repair in a Cell Lineage Model of Human Proliferative Breast Disease (PBD)
Toxicol. Sci., September 1, 2003; 75(1): 74 - 81.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Yamane, J. Chen, and T. J. Kinsella
Both DNA Topoisomerase II-binding Protein 1 and BRCA1 Regulate the G2-M Cell Cycle Checkpoint
Cancer Res., June 15, 2003; 63(12): 3049 - 3053.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Deutsch, S. Jarrousse, D. Buet, A. Dugray, M.-L. Bonnet, M.-C. Vozenin-Brotons, F. Guilhot, A. G. Turhan, J. Feunteun, and J. Bourhis
Down-regulation of BRCA1 in BCR-ABL-expressing hematopoietic cells
Blood, June 1, 2003; 101(11): 4583 - 4588.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Miralem and H. K. Avraham
Extracellular Matrix Enhances Heregulin-Dependent BRCA1 Phosphorylation and Suppresses BRCA1 Expression through Its C Terminus
Mol. Cell. Biol., January 15, 2003; 23(2): 579 - 593.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Okada and T. Ouchi
Cell Cycle Differences in DNA Damage-induced BRCA1 Phosphorylation Affect Its Subcellular Localization
J. Biol. Chem., January 10, 2003; 278(3): 2015 - 2020.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q. Zhong, C.-F. Chen, P.-L. Chen, and W.-H. Lee
BRCA1 Facilitates Microhomology-mediated End Joining of DNA Double Strand Breaks
J. Biol. Chem., August 2, 2002; 277(32): 28641 - 28647.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Q. Zhong, T. G. Boyer, P.-L. Chen, and W.-H. Lee
Deficient Nonhomologous End-Joining Activity in Cell-free Extracts from Brca1-null Fibroblasts
Cancer Res., July 15, 2002; 62(14): 3966 - 3970.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. N. Andrews, P. B. Mullan, S. McWilliams, S. Sebelova, J. E. Quinn, P. M. Gilmore, N. McCabe, A. Pace, B. Koller, P. G. Johnston, et al.
BRCA1 Regulates the Interferon gamma -mediated Apoptotic Response
J. Biol. Chem., July 12, 2002; 277(29): 26225 - 26232.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. K. MacLachlan and W. S. El-Deiry
Apoptotic threshold is lowered by p53 transactivation of caspase-6
PNAS, July 9, 2002; 99(14): 9492 - 9497.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. Foray, D. Marot, V. Randrianarison, N. D. Venezia, D. Picard, M. Perricaudet, V. Favaudon, and P. Jeggo
Constitutive Association of BRCA1 and c-Abl and Its ATM-Dependent Disruption after Irradiation
Mol. Cell. Biol., June 15, 2002; 22(12): 4020 - 4032.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. K. MacLachlan, R. Takimoto, and W. S. El-Deiry
BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets
Mol. Cell. Biol., June 15, 2002; 22(12): 4280 - 4292.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. L. Welcsh, M. K. Lee, R. M. Gonzalez-Hernandez, D. J. Black, M. Mahadevappa, E. M. Swisher, J. A. Warrington, and M.-C. King
BRCA1 transcriptionally regulates genes involved in breast tumorigenesis
PNAS, May 28, 2002; 99(11): 7560 - 7565.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-Y. Ahn, X. Li, H. L. Davis, and C. E. Canman
Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated Domain
J. Biol. Chem., May 24, 2002; 277(22): 19389 - 19395.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K.-B. Lee, D. Wang, S. J. Lippard, and P. A. Sharp
Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro
PNAS, April 2, 2002; 99(7): 4239 - 4244.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. A. Grushko, M. A. Blackwood, P. L. Schumm, F. G. Hagos, M. O. Adeyanju, M. D. Feldman, M. O. Sanders, B. L. Weber, and O. I. Olopade
Molecular-Cytogenetic Analysis of HER-2/neu Gene in BRCA1-associated Breast Cancers
Cancer Res., March 1, 2002; 62(5): 1481 - 1488.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Zheng, L. A. Annab, C. A. Afshari, W.-H. Lee, and T. G. Boyer
BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor
PNAS, August 1, 2001; (2001) 171174298.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Ruffner, C. A. P. Joazeiro, D. Hemmati, T. Hunter, and I. M. Verma
Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity
PNAS, April 24, 2001; 98(9): 5134 - 5139.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Wang, Z.-C. Zeng, T.-A. Bui, S. J. DiBiase, W. Qin, F. Xia, S. N. Powell, and G. Iliakis
Nonhomologous End-Joining of Ionizing Radiation-induced DNA Double-Stranded Breaks in Human Tumor Cells Deficient in BRCA1 or BRCA2
Cancer Res., January 1, 2001; 61(1): 270 - 277.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
R. S. Tibbetts, D. Cortez, K. M. Brumbaugh, R. Scully, D. Livingston, S. J. Elledge, and R. T. Abraham
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
Genes & Dev., December 1, 2000; 14(23): 2989 - 3002.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
F. Le Page, V. Randrianarison, D. Marot, J. Cabannes, M. Perricaudet, J. Feunteun, and A. Sarasin
BRCA1 and BRCA2 Are Necessary for the Transcription-Coupled Repair of the Oxidative 8-Oxoguanine Lesion in Human Cells
Cancer Res., October 1, 2000; 60(19): 5548 - 5552.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
T. K. MacLachlan, K. Somasundaram, M. Sgagias, Y. Shifman, R. J. Muschel, K. H. Cowan, and W. S. El-Deiry
BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression
J. Biol. Chem., January 28, 2000; 275(4): 2777 - 2785.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
X. WU, G. RATHBUN, W.S. LANE, D.T. WEAVER, and D.M. LIVINGSTON
Interactions of the Nijmegen Breakage Syndrome Protein with ATM and BRCA1
Cold Spring Harb Symp Quant Biol, January 1, 2000; 65(0): 535 - 546.
[Abstract] [PDF]

Home page
 ScienceHome page
D. Cortez, Y. Wang, J. Qin, and S. J. Elledge
Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks
Science, November 5, 1999; 286(5442): 1162 - 1166.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
S.-S. F. Yuan, S.-Y. Lee, G. Chen, M. Song, G. E. Tomlinson, and E. Y-H. P. Lee
BRCA2 Is Required for Ionizing Radiation-induced Assembly of Rad51 Complex in Vivo
Cancer Res., August 1, 1999; 59(15): 3547 - 3551.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
Q. Zhong, C. Chen, S. Li, Y. Chen, C. Wang, J. Xiao, P. Chen, Z. D. Sharp, and W. Lee
Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response
Science, July 30, 1999; 285(5428): 747 - 750.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
Z. Dong, Q. Zhong, and P.-L. Chen
The Nijmegen Breakage Syndrome Protein Is Essential for Mre11 Phosphorylation upon DNA Damage
J. Biol. Chem., July 9, 1999; 274(28): 19513 - 19516.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. W. Abbott, M. E. Thompson, C. Robinson-Benion, G. Tomlinson, R. A. Jensen, and J. T. Holt
BRCA1 Expression Restores Radiation Resistance in BRCA1-defective Cancer Cells through Enhancement of Transcription-coupled DNA Repair
J. Biol. Chem., June 25, 1999; 274(26): 18808 - 18812.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Yoshikawa, K. Honda, T. Inamoto, H. Shinohara, A. Yamauchi, K. Suga, T. Okuyama, T. Shimada, H. Kodama, S. Noguchi, et al.
Reduction of BRCA1 Protein Expression in Japanese Sporadic Breast Carcinomas and Its Frequent Loss in BRCA1-associated Cases
Clin. Cancer Res., June 1, 1999; 5(6): 1249 - 1261.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. I. Yarden and L. C. Brody
BRCA1 interacts with components of the histone deacetylase complex
PNAS, April 27, 1999; 96(9): 4983 - 4988.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Li, P.-L. Chen, T. Subramanian, G. Chinnadurai, G. Tomlinson, C. K. Osborne, Z. D. Sharp, and W.-H. Lee
Binding of CtIP to the BRCT Repeats of BRCA1 Involved in the Transcription Regulation of p21 Is Disrupted Upon DNA Damage
J. Biol. Chem., April 16, 1999; 274(16): 11334 - 11338.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
S. Matsuoka, M. Huang, and S. J. Elledge
Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase
Science, December 4, 1998; 282(5395): 1893 - 1897.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
Y.-F. Hu, T. Miyake, Q. Ye, and R. Li
Characterization of a Novel Trans-Activation Domain of BRCA1 That Functions in Concert with the BRCA1 C-terminal (BRCT) Domain
J. Biol. Chem., December 22, 2000; 275(52): 40910 - 40915.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Thangaraju, S. H. Kaufmann, and F. J. Couch
BRCA1 Facilitates Stress-induced Apoptosis in Breast and Ovarian Cancer Cell Lines
J. Biol. Chem., October 20, 2000; 275(43): 33487 - 33496.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K.-B. Lee, D. Wang, S. J. Lippard, and P. A. Sharp
Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro
PNAS, April 2, 2002; 99(7): 4239 - 4244.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Ouchi, S. W. Lee, M. Ouchi, S. A. Aaronson, and C. M. Horvath
Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes
PNAS, May 9, 2000; 97(10): 5208 - 5213.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Zheng, L. A. Annab, C. A. Afshari, W.-H. Lee, and T. G. Boyer
BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor
PNAS, August 14, 2001; 98(17): 9587 - 9592.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1998 by the American Association for Cancer Research.