| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of Pathology and Cancer Research Institute, Catholic University Medical College, Seoul 137-701 [S. M. D., K. M. K., Su Y. K., M. S. S., E. Y. N., S. H. L., W. S. P., N. J. Y., J. W. K., Se Y. K., S. H. K., C. S. K., J. Y. L.]; Department of Pathology, Seoul National University College of Medicine, and Cancer Research Center, Seoul 110-799 [J. J. J.]; Korea Food and Drug Administration, Seoul 122-020 [C. Y. Y.]; and Genetic Laboratory of Premedical Course, Kon-Kuk University College of Medicine, Chung-Ju 380-060 [Y. M. Y.], Korea
We analyzed somatic mutation and loss of heterozygosity (LOH) in the serine/threonine kinase 11 (STK11)/Peutz-Jeghers syndrome gene in 49 colorectal tumors in three different stages of a dysplasia-carcinoma sequence. We detected LOH in 10 of 19 (52.6%) informative colorectal cancers at loci D19S886 and/or D19S883, but no LOH was observed in 25 informative adenomas. We detected a total of 9 somatic mutations [7 of 13 (53.8%) left-sided colon cancers and 2 of 7 (28.6%) left-sided adenomas with high-grade dysplasia], but no mutations were detected in right-sided colon tumors. Of the nine mutations, one was a frameshift mutation (the same mutation detected in Peutz-Jeghers syndrome family previously), and the other eight were missense mutations. This results indicate that STK11 is a tumor suppressor gene and that genetic changes of STK11 play an important role in left-sided colon cancer carcinogenesis.
1 This work was supported by funding from the "Good Health R&D Project" of the Ministry of Health Welfare of Korea (Grant HMP-98-M-2-0018).
2 The first two authors contributed equally to this study.
3 To whom requests for reprints should be addressed, at Dept. of Pathology, Catholic University Medical College, Seoul 137-701, Korea.
Received 4/23/98. Accepted 7/17/98.
This article has been cited by other articles:
|
|
 |
|
  P.-Y. Zeng and S. L. Berger LKB1 Is Recruited to the p21/WAF1 Promoter by p53 to Mediate Transcriptional Activation. Cancer Res., November 15, 2006; 66(22): 10701 - 10708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Forcet, S. Etienne-Manneville, H. Gaude, L. Fournier, S. Debilly, M. Salmi, A. Baas, S. Olschwang, H. Clevers, and M. Billaud Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity Hum. Mol. Genet., May 15, 2005; 14(10): 1283 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V Schumacher, T Vogel, B Leube, C Driemel, T Goecke, G Moslein, and B Royer-Pokora STK11 genotyping and cancer risk in Peutz-Jeghers syndrome J. Med. Genet., May 1, 2005; 42(5): 428 - 435. [Full Text] [PDF]
|
|
|
|
|
|
C I Amos, M B Keitheri-Cheteri, M Sabripour, C Wei, T J McGarrity, M F Seldin, L Nations, P M Lynch, H H Fidder, E Friedman, et al. Genotype-phenotype correlations in Peutz-Jeghers syndrome J. Med. Genet., May 1, 2004; 41(5): 327 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L F Forster, S Defres, D R Goudie, D U Baty, and F A Carey An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers J. Clin. Pathol., October 1, 2000; 53(10): 791 - 793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Trojan, A Brieger, J Raedle, M Esteller, and S Zeuzem 5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer Gut, August 1, 2000; 47(2): 272 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Launonen, E. Avizienyte, A. Loukola, P. Laiho, R. Salovaara, H. Jarvinen, J.-P. Mecklin, A. Oku, M. Shimane, H. C. Kim, et al. No Evidence of Peutz-Jeghers Syndrome Gene LKB1 Involvement in Left-sided Colorectal Carcinomas Cancer Res., February 1, 2000; 60(3): 546 - 548. [Abstract] [Full Text]
|
|
|
|
|
|
W. S. Park, J. Y. Park, R. R. Oh, N. J. Yoo, S. H. Lee, M. S. Shin, H. K. Lee, S. Han, S. K. Yoon, S. Y. Kim, et al. A Distinct Tumor Suppressor Gene Locus on Chromosome 15q21.1 in Sporadic Form of Colorectal Cancer Cancer Res., January 1, 2000; 60(1): 70 - 73. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. C. Connolly, H. Katabuchi, W. A. Cliby, and K. R. Cho Somatic Mutations in the STK11/LKB1 Gene Are Uncommon in Rare Gynecological Tumor Types Associated with Peutz-Jegher’s Syndrome Am. J. Pathol., January 1, 2000; 156(1): 339 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. CHEN, E. AVIZIENYTE, S. ROTH, I. LEIVO, A. A MAKITIE, L.-M. AALTONEN, and L. A AALTONEN PTEN and LKB1 genes in laryngeal tumours J. Med. Genet., December 1, 1999; 36(12): 943 - 944. [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Potter Colorectal Cancer: Molecules and Populations J Natl Cancer Inst, June 2, 1999; 91(11): 916 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Su, R. H. Hruban, R. K. Bansal, G. S. Bova, D. J. Tang, M. C. Shekher, A. M. Westerman, M. M. Entius, M. Goggins, C. J. Yeo, et al. Germline and Somatic Mutations of the STK11/LKB1 Peutz-Jeghers Gene in Pancreatic and Biliary Cancers Am. J. Pathol., June 1, 1999; 154(6): 1835 - 1840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z-J Wang, M Churchman, E Avizienyte, C McKeown, S Davies, D G R Evans, A Ferguson, I Ellis, W.-H. Xu, Z.-Y. Yan, et al. Germline mutations of the LKB1 (STK11) gene in Peutz-Jeghers patients J. Med. Genet., May 1, 1999; 36(5): 365 - 368. [Abstract] [Full Text]
|
|
|
|
|
|
E. Avizienyte, A. Loukola, S. Roth, A. Hemminki, M. Tarkkanen, R. Salovaara, J. Arola, R. Butzow, K. Husgafvel-Pursiainen, A. Kokkola, et al. LKB1 Somatic Mutations in Sporadic Tumors Am. J. Pathol., March 1, 1999; 154(3): 677 - 681. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
