.JPG?ad=18503&adview=true)
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Division of Applied Pharmacological Research, Food and Drug Administration (HFD-910), Laurel, Maryland 20908 [E. H. H., J. Z.]; Division of Pediatric Cardiology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York 14642 [S. E. L.]; Department of Laboratory Medicine, Children's Hospital, Boston, Massachusetts 02115 [N. R.]; Division of Cardiorenal Drug Products, Food and Drug Administration, (HFD-110), Rockville, Maryland 20852 [T. P.]; and Pathology Section, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892 [Z-X. Y., K. T., V. J. F.]
The release of cardiac troponin T (cTnT) as a biomarker of doxorubicin-induced chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model. Elevations in serum levels of cTnT and decreased immunohistochemical staining of heart sections for this protein were noted in SHRs treated with cumulative doses of doxorubicin (7 mg/kg) that induced only minimal histological alterations in myocytes. Concentrations of cTnT were further elevated, coincident with reduced immunohistochemical staining, in SHRs given 10–12 mg/kg doxorubicin.
Thus, monitoring serum levels of cTnT can detect doxorubicin-induced myocyte damage in SHR and may prove useful for the noninvasive evaluation of this toxicity in humans.
1 To whom requests for reprints should be addressed, at Division of Applied Pharmacological Research (HFD-910), Center for Drug Evaluation and Research, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708. Phone: (301) 594-6020; Fax: (301) 594-3037
Received 9/15/97. Accepted 12/ 1/97.
This article has been cited by other articles:
|
|
 |
|
  J. Zhang, A. Knapton, S. E. Lipshultz, J. L. Weaver, and E. H. Herman Isoproterenol-induced Cardiotoxicity in Sprague-Dawley Rats: Correlation of Reversible and Irreversible Myocardial Injury with Release of Cardiac Troponin T and Roles of iNOS in Myocardial Injury Toxicol Pathol, February 1, 2008; 36(2): 277 - 278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. York, C. Scudamore, S. Brady, C. Chen, S. Wilson, M. Curtis, G. Evans, W. Griffiths, M. Whayman, T. Williams, et al. Characterization of Troponin Responses in Isoproterenol-Induced Cardiac Injury in the Hanover Wistar Rat Toxicol Pathol, June 1, 2007; 35(4): 606 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Piekarz, A. R. Frye, J. J. Wright, S. M. Steinberg, D. J. Liewehr, D. R. Rosing, V. Sachdev, T. Fojo, and S. E. Bates Cardiac Studies in Patients Treated with Depsipeptide, FK228, in a Phase II Trial for T-Cell Lymphoma. Clin. Cancer Res., June 15, 2006; 12(12): 3762 - 3773. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Walker Serum Chemical Biomarkers of Cardiac Injury for Nonclinical Safety Testing Toxicol Pathol, January 1, 2006; 34(1): 94 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Floyd, D. T. Nguyen, R. L. Lobins, Q. Bashir, D. C. Doll, and M. C. Perry Cardiotoxicity of Cancer Therapy J. Clin. Oncol., October 20, 2005; 23(30): 7685 - 7696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kilickap, I. Barista, E. Akgul, K. Aytemir, S. Aksoyek, S. Aksoy, I. Celik, S. Kes, and G. Tekuzman cTnT can be a useful marker for early detection of anthracycline cardiotoxicity Ann. Onc., May 1, 2005; 16(5): 798 - 804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Lipshultz, N. Rifai, V. M. Dalton, D. E. Levy, L. B. Silverman, S. R. Lipsitz, S. D. Colan, B. L. Asselin, R. D. Barr, L. A. Clavell, et al. The Effect of Dexrazoxane on Myocardial Injury in Doxorubicin-Treated Children with Acute Lymphoblastic Leukemia N. Engl. J. Med., July 8, 2004; 351(2): 145 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Dunnick, W. Lieuallen, C. Moyer, D. Orzech, and A. Nyska Cardiac Damage in Rodents after Exposure to Bis(2-chloroethoxy)methane Toxicol Pathol, April 1, 2004; 32(3): 309 - 317. [Abstract] [PDF]
|
|
|
|
|
|
K. B. Wallace, E. Hausner, E. Herman, G. D. Holt, J. T. Macgregor, A. L. Metz, E. Murphy, I.Y. Rosenblum, F. D. Sistare, and M. J. York Serum Troponins as Biomarkers of Drug-Induced Cardiac Toxicity Toxicol Pathol, January 1, 2004; 32(1): 106 - 121. [PDF]
|
|
|
|
 |
|
 A. van der Laarse Hypothesis: troponin degradation is one of the factors responsible for deterioration of left ventricular function in heart failure Cardiovasc Res, October 1, 2002; 56(1): 8 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Cardinale, M. T. Sandri, A. Martinoni, E. Borghini, M. Civelli, G. Lamantia, S. Cinieri, G. Martinelli, C. Fiorentini, and C. M. Cipolla Myocardial injury revealed by plasma troponin I in breast cancer treated with high-dose chemotherapy Ann. Onc., May 1, 2002; 13(5): 710 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. W. Auner, C. Tinchon, W. Linkesch, G. Halwachs-Baumann, and H. Sill Correspondence re: O. J. Arola et al., Acute Doxorubicin Cardiotoxicity Involves Cardiomyocyte Apoptosis. Cancer Res., 60: 1789-1792, 2000. Cancer Res., March 1, 2001; 61(5): 2335 - 2336. [Full Text]
|
|
|
|
 |
|
 D. Cardinale, M. T. Sandri, A. Martinoni, A. Tricca LabTech, M. Civelli, G. Lamantia, S. Cinieri, G. Martinelli, C. M. Cipolla, and C. Fiorentini Left ventricular dysfunction predicted by early troponin I release after high-dose chemotherapy J. Am. Coll. Cardiol., August 1, 2000; 36(2): 517 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Feleszko, I. Mlynarczuk, E. Z. Balkowiec-Iskra, A. Czajka, T. Switaj, T. Stoklosa, A. Giermasz, and M. Jakóbisiak Lovastatin Potentiates Antitumor Activity and Attenuates Cardiotoxicity of Doxorubicin in Three Tumor Models in Mice Clin. Cancer Res., May 1, 2000; 6(5): 2044 - 2052. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Fredericks, P. O. Collinson, D. W. Holt, P. A. Isotalo, D. C. Greenway, and J. G. Donnelly Response to ""Increased Creatine Kinase MB and Cardiac Troponin T with Normal Cardiac Troponin I in Metastatic Alveolar Rhabdomyosarcoma"" • The authors of the Letter cited above reply: Clin. Chem., March 1, 2000; 46(3): 432 - 435. [Full Text] [PDF]
|
|
|
|
|
|
E. H. Herman, J. Zhang, S. E. Lipshultz, N. Rifai, D. Chadwick, K. Takeda, Z.-X. Yu, and V. J. Ferrans Correlation Between Serum Levels of Cardiac Troponin-T and the Severity of the Chronic Cardiomyopathy Induced by Doxorubicin J. Clin. Oncol., July 1, 1999; 17(7): 2237 - 2237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.C.M. Kremer, M.M.C. Tiel-van Buul, M.C. Ubbink, M. Offringa, J. Ottenkamp, R. V. Olmos, and P.A. Voute Indium-111-Antimyosin Scintigraphy in the Early Detection of Heart Damage After Anthracycline Therapy in Children J. Clin. Oncol., April 1, 1999; 17(4): 1208 - 1208. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
