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[Cancer Research 58, 5061-5065, November 15, 1998]
© 1998 American Association for Cancer Research
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The Potential Tumor Suppressor p73 Differentially Regulates Cellular p53 Target Genes1

Jianhui Zhu2, Jieyuan Jiang2, Wenjing Zhou and Xinbin Chen3

Intitute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912

p73, a potential tumor suppressor, is a p53 homologue. Transient over expression of p73 in cells can induce apoptosis and p21, a cellular p53 target gene primarily responsible for p53-dependent cell cycle arrest. To further characterize the role of p73 in tumor suppression, we established several groups of cell lines that inducibly express p73 under a tetracycline-regulated promoter. By using these cell lines, we found that p73 can induce both cell cycle arrest and apoptosis. We also found that p73 can activate some but not all of the previously identified p53 cellular target genes. Furthermore, we found that the transcriptional activities of p53, p73{alpha}, and p73ß to induce their common cellular target genes differ among one another. These results suggest that p73 is both similar to and different from p53 in their signaling pathways leading to tumor suppression.

1 Supported in part by National Cancer Institute Grant CA 76069 and the United States Department of Defense Army Breast Cancer Program Grant DAMD17-97-I-7019.

2 These authors contributed equally to this work.

3 To whom requests for reprints should be addressed, at CB-2803/IMMAG, Medical College of Georgia, Augusta, GA 30912. Phone: (706) 721-8760; Fax: (706) 721-8752; E-mail: xchen@mail.mcg.edu.

Received 9/ 2/98. Accepted 10/ 1/98.




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J. Biol. Chem., June 18, 2004; 279(25): 26300 - 26306.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

Home page
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G. Melino, F. Bernassola, M. Ranalli, K. Yee, W. X. Zong, M. Corazzari, R. A. Knight, D. R. Green, C. Thompson, and K. H. Vousden
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J. Biol. Chem., February 27, 2004; 279(9): 8076 - 8083.
[Abstract] [Full Text] [PDF]

Home page
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G. Liu, S. Nozell, H. Xiao, and X. Chen
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Mol. Cell. Biol., January 15, 2004; 24(2): 487 - 501.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
D. Goldschneider, E. Blanc, G. Raguenez, M. Barrois, A. Legrand, G. Le Roux, H. Haddada, J. Benard, and S. Douc-Rasy
Differential response of p53 target genes to p73 overexpression in SH-SY5Y neuroblastoma cell line
J. Cell Sci., January 15, 2004; 117(2): 293 - 301.
[Abstract] [Full Text] [PDF]

Home page
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F. N. Barrera, J. A. Poveda, J. M. Gonzalez-Ros, and J. L. Neira
Binding of the C-terminal Sterile {alpha} Motif (SAM) Domain of Human p73 to Lipid Membranes
J. Biol. Chem., November 21, 2003; 278(47): 46878 - 46885.
[Abstract] [Full Text] [PDF]

Home page
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S. Gonzalez, C. Prives, and C. Cordon-Cardo
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Mol. Cell. Biol., November 15, 2003; 23(22): 8161 - 8171.
[Abstract] [Full Text] [PDF]

Home page
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M. Marabese, F. Vikhanskaya, C. Rainelli, T. Sakai, and M. Broggini
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Nucleic Acids Res., November 15, 2003; 31(22): 6624 - 6632.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. Puig, P. Capodieci, M. Drobnjak, D. Verbel, C. Prives, C. Cordon-Cardo, and C. J. Di Como
p73 Expression in Human Normal and Tumor Tissues: Loss of p73{alpha} Expression Is Associated with Tumor Progression in Bladder Cancer
Clin. Cancer Res., November 15, 2003; 9(15): 5642 - 5651.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
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p73 Tumor-Suppressor Activity Is Impaired in Human Thyroid Cancer
Cancer Res., September 15, 2003; 63(18): 5829 - 5837.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
O. Petrenko, A. Zaika, and U. M. Moll
{Delta}Np73 Facilitates Cell Immortalization and Cooperates with Oncogenic Ras in Cellular Transformation In Vivo
Mol. Cell. Biol., August 15, 2003; 23(16): 5540 - 5555.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. A. Sablina, P. M. Chumakov, and B. P. Kopnin
Tumor Suppressor p53 and Its Homologue p73{alpha} Affect Cell Migration
J. Biol. Chem., July 18, 2003; 278(30): 27362 - 27371.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Gaiddon, M. Lokshin, I. Gross, D. Levasseur, Y. Taya, J.-P. Loeffler, and C. Prives
Cyclin-dependent Kinases Phosphorylate p73 at Threonine 86 in a Cell Cycle-dependent Manner and Negatively Regulate p73
J. Biol. Chem., July 18, 2003; 278(30): 27421 - 27431.
[Abstract] [Full Text] [PDF]

Home page
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J. Biol. Chem., January 17, 2003; 278(4): 2249 - 2255.
[Abstract] [Full Text] [PDF]

Home page
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J. Exp. Med., September 16, 2002; 196(6): 765 - 780.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Ren, R. Datta, H. Shioya, Y. Li, E. Oki, V. Biedermann, A. Bharti, and D. Kufe
p73beta Is Regulated by Protein Kinase Cdelta Catalytic Fragment Generated in the Apoptotic Response to DNA Damage
J. Biol. Chem., September 6, 2002; 277(37): 33758 - 33765.
[Abstract] [Full Text] [PDF]

Home page
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Mol. Cancer Ther., June 1, 2002; 1(8): 639 - 649.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-i. Watanabe, T. Ozaki, T. Nakagawa, K. Miyazaki, M. Takahashi, M. Hosoda, S. Hayashi, S. Todo, and A. Nakagawara
Physical Interaction of p73 with c-Myc and MM1, a c-Myc-binding Protein, and Modulation of the p73 Function
J. Biol. Chem., April 19, 2002; 277(17): 15113 - 15123.
[Abstract] [Full Text] [PDF]

Home page
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T. Nakagawa, M. Takahashi, T. Ozaki, K.-i. Watanabe, S. Todo, H. Mizuguchi, T. Hayakawa, and A. Nakagawara
Autoinhibitory Regulation of p73 by {Delta}Np73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the {Delta}Np73 Promoter
Mol. Cell. Biol., April 15, 2002; 22(8): 2575 - 2585.
[Abstract] [Full Text] [PDF]

Home page
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E. Balint, A. C. Phillips, S. Kozlov, C. L. Stewart, and K. H. Vousden
Induction of p57KIP2 expression by p73beta
PNAS, March 19, 2002; 99(6): 3529 - 3534.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Sasaki, S. Ishida, I. Morimoto, T. Yamashita, T. Kojima, C. Kihara, T. Tanaka, K. Imai, Y. Nakamura, and T. Tokino
The p53 Family Member Genes Are Involved in the Notch Signal Pathway
J. Biol. Chem., January 4, 2002; 277(1): 719 - 724.
[Abstract] [Full Text]

Home page
 Mol. Cell. Biol.Home page
J. Gu, L. Nie, D. Wiederschain, and Z.-M. Yuan
Identification of p53 Sequence Elements That Are Required for MDM2-Mediated Nuclear Export
Mol. Cell. Biol., December 15, 2001; 21(24): 8533 - 8546.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. D. Strachan, R. Rallapalli, B. Pucci, T. P. Lafond, and D. J. Hall
A Transcriptionally Inactive E2F-1 Targets the MDM Family of Proteins for Proteolytic Degradation
J. Biol. Chem., November 30, 2001; 276(49): 45677 - 45685.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
P A Hall, A C Woodman, S J Campbell, and N A Shepherd
Expression of the p53 homologue p63{alpha} and {Delta}Np63{alpha} in the neoplastic sequence of Barrett's oesophagus: correlation with morphology and p53 protein
Gut, November 1, 2001; 49(5): 618 - 623.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
M. S. Irwin and W. G. Kaelin
p53 Family Update: p73 and p63 Develop Their Own Identities
Cell Growth Differ., July 1, 2001; 12(7): 337 - 349.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Moriyama, S. Nishiguchi, A. Tamori, N. Koh, Y. Yano, S. Kubo, K. Hirohashi, and S. Otani
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Clin. Cancer Res., May 1, 2001; 7(5): 1293 - 1298.
[Abstract] [Full Text]

Home page
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Mol. Cell. Biol., March 1, 2001; 21(5): 1874 - 1887.
[Abstract] [Full Text]

Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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X. Q. Wang, W. M. Ongkeko, A. W. S. Lau, K. M. Leung, and R. Y. C. Poon
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Cancer Res., February 1, 2001; 61(4): 1598 - 1603.
[Abstract] [Full Text]

Home page
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Home page
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Home page
 CarcinogenesisHome page
P. A. Hall, S. J. Campbell, M. O'neill, D. J. Royston, K. Nylander, F. A. Carey, and N. M. Kernohan
Expression of the p53 homologue p63{alpha} and {Delta}Np63{alpha} in normal and neoplasticcells
Carcinogenesis, February 1, 2000; 21(2): 153 - 160.
[Abstract] [Full Text] [PDF]

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 J. Cell Sci.Home page
M Levrero, V De Laurenzi, A Costanzo, J Gong, J. Wang, and G Melino
The p53/p63/p73 family of transcription factors: overlapping and distinct functions
J. Cell Sci., January 5, 2000; 113(10): 1661 - 1670.
[Abstract] [PDF]

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 J. Virol.Home page
S. Wienzek, J. Roth, and M. Dobbelstein
E1B 55-Kilodalton Oncoproteins of Adenovirus Types 5 and 12 Inactivate and Relocalize p53, but Not p51 or p73, and Cooperate with E4orf6 Proteins To Destabilize p53
J. Virol., January 1, 2000; 74(1): 193 - 202.
[Abstract] [Full Text]

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 J. Gen. Virol.Home page
J. Roth and M. Dobbelstein
Failure of viral oncoproteins to target the p53-homologue p51A
J. Gen. Virol., December 1, 1999; 80(12): 3251 - 3255.
[Abstract] [Full Text]

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 Cancer Res.Home page
T. Ozaki, M. Naka, N. Takada, M. Tada, S. Sakiyama, and A. Nakagawara
Deletion of the COOH-Terminal Region of p73{{alpha}} Enhances Both Its Transactivation Function and DNA-binding Activity but Inhibits Induction of Apoptosis in Mammalian Cells
Cancer Res., December 1, 1999; 59(23): 5902 - 5907.
[Abstract] [Full Text] [PDF]

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 JCBHome page
L. Fang, S. W. Lee, and S. A. Aaronson
Comparative Analysis of P73 and P53 Regulation and Effector Functions
J. Cell Biol., November 15, 1999; 147(4): 823 - 830.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
U. R. Peters, M. P. Tschan, K. A. Kreuzer, G. Baskaynak, U. Lass, A. Tobler, M. F. Fey, and C. A. Schmidt
Distinct Expression Patterns of the p53-Homologue p73 in Malignant and Normal Hematopoiesis Assessed by a Novel Real-Time Reverse Transcription-Polymerase Chain Reaction Assay and Protein Analysis
Cancer Res., September 1, 1999; 59(17): 4233 - 4236.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
A. I. Zaika, S. Kovalev, N. D. Marchenko, and U. M. Moll
Overexpression of the Wild Type p73 Gene in Breast Cancer Tissues and Cell Lines
Cancer Res., July 1, 1999; 59(13): 3257 - 3263.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
P. G. Corn, S. J. Kuerbitz, M. M. van Noesel, M. Esteller, N. Compitello, S. B. Baylin, and J. G. Herman
Transcriptional Silencing of the p73 Gene in Acute Lymphoblastic Leukemia and Burkitt's Lymphoma Is Associated with 5' CpG Island Methylation
Cancer Res., July 1, 1999; 59(14): 3352 - 3356.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
A. Shimada, S. Kato, K. Enjo, M. Osada, Y. Ikawa, K. Kohno, M. Obinata, R. Kanamaru, S. Ikawa, and C. Ishioka
The Transcriptional Activities of p53 and Its Homologue p51/p63: Similaritiesand Differences
Cancer Res., June 1, 1999; 59(12): 2781 - 2786.
[Abstract] [Full Text] [PDF]

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 Cancer Res.Home page
S.-G. Chi, S.-G. Chang, S.-J. Lee, C.-H. Lee, J. I. Kim, and J.-H. Park
Elevated and Biallelic Expression of p73 Is Associated with Progression of Human Bladder Cancer
Cancer Res., June 1, 1999; 59(12): 2791 - 2793.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
X. Zeng, H. Lee, Q. Zhang, and H. Lu
p300 Does Not Require Its Acetylase Activity to Stimulate p73 Function
J. Biol. Chem., January 5, 2001; 276(1): 48 - 52.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
A. Zaika, M. Irwin, C. Sansome, and U. M. Moll
Oncogenes Induce and Activate Endogenous p73 Protein
J. Biol. Chem., March 30, 2001; 276(14): 11310 - 11316.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
I. Lemasson and J. K. Nyborg
Human T-cell Leukemia Virus Type I Tax Repression of p73beta Is Mediated through Competition for the C/H1 Domain of CBP
J. Biol. Chem., May 4, 2001; 276(19): 15720 - 15727.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
C. Klein, G. Georges, K.-P. Kunkele, R. Huber, R. A. Engh, and S. Hansen
High Thermostability and Lack of Cooperative DNA Binding Distinguish the p63 Core Domain from the Homologous Tumor Suppressor p53
J. Biol. Chem., September 28, 2001; 276(40): 37390 - 37401.
[Abstract] [Full Text] [PDF]


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