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Intramural Research Support Program, Science Applications International Corporation-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland 21702-1201 [R. A., A. H.]; National Cancer Institute, Laboratory of Genomic Diversity, Frederick, Maryland 21702-1201 [L. M. S., M. D.]; and Institute of Hygiene and Public Health, Faculty of Medicine of the Catholic University, 00168 Rome, Italy [V. R-S.]
We characterized a new human ATP-binding cassette (ABC) transporter gene that is highly expressed in the placenta. The gene, ABCP, produces two transcripts that differ at the 5' end and encode the same 655-amino acid protein. The predicted protein is closely related to the Drosophila white and yeast ADP1 genes and is a member of a subfamily that includes several multidrug resistance transporters. ABCP, white, and ADP1 all have a single ATP-binding domain at the NH2 terminus and a single COOH-terminal set of transmembrane segments. ABCP maps to human chromosome 4q22, between the markers D4S2462 and D4S1557, and the murine gene (Abcp) is located on chromosome 6 28–29 cM from the centromere. ABCP defines a new syntenic segment between human chromosome 4 and mouse chromosome 6. The abundant expression of this gene in the placenta suggests that the protein product has an important role in transport of specific molecule(s) into or out of this tissue.
1 This project was funded in part with Federal funds from the National Cancer Institute, NIH, under Contract No. NO1-CO-56000.
2 To whom requests for reprints should be addressed. Phone: (301) 846-5931; Fax: (301) 846-1909; E-mail: dean@mail.ncifcrf.gov.
Received 10/ 2/98. Accepted 10/19/98.
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