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Chain in T Cells at the Tumor Site Correlates with Poor Survival in Patients with Oral Carcinoma1
Department of Maxillofacial Surgery, University of Mainz, 55131 Mainz, Germany [T. E. R., E. M. W.]; and Departments of Biostatistics [R. D.], Pathology [T. L. W.], and Otolaryngology [T. L. W.], University of Pittsburgh, and University of Pittsburgh Cancer Institute [R. D., T. L. W.], Pittsburgh, Pennsylvania 15213
Immunohistology for expression of the CD3
and CD3
chains in TIL was performed in 138 paraffin-embedded primary oral squamous cell carcinoma tissues and 10 nontumor, inflammatory lesions. Semiquantitative analysis of the staining intensity for chain expression and number of chain expression-positive cells distinguished tumors with absent or low expression (42 of 132) from those with normal expression (90 of 132). chain expression was inversely correlated with the tumor stage. Survival was significantly lower in patients whose TIL had absent or low expression, controlling for stage (P = 0.003) and lymph node status (P = 0.0005). The prognostic value of chain was restricted to patients with stage III or IV tumors (P = 0.003). The data indicate that absent or decreased expression in TIL combined with tumor stage or nodal status defines a group of patients with oral squamous cell carcinoma who have an extremely poor prognosis.
1 Supported in part by NIH Grant P01-DE 12321 (to T. L. W.).
2 To whom requests for reprints should be addressed, at University of Pittsburgh Cancer Institute, W1041 BST, 211 Lothrop Street, Pittsburgh, PA 15213-2582. Phone: (412) 624-0080; Fax: (412) 624-0264; E-mail: Whitesidetl@msx.upmc.edu.
Received 8/17/98. Accepted 10/19/98.
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