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Department of Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905
To better understand genetic alterations in atypical adenomatous hyperplasia (AAH) of the prostate, we examined the prevalence of allelic imbalance at 5 microsatellite polymorphic markers on chromosomes 7q31–35, 8p12–21, 8p22, 8q22.2, and 18q12.2 from 15 patients with AAH. DNA samples were obtained from formalin-fixed paraffin-embedded sections using tissue microdissection. We found allelic imbalance in 7 of 15 (47%) cases of AAH. Genetic changes that commonly occur in early prostatic carcinogenesis and prostate carcinoma are found in AAH. Current data provide evidence of a genetic link between some cases of AAH and carcinoma.
1 To whom requests for reprints should be addressed, at Department of Pathology and Laboratory Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. Phone: (507) 284-1870; Fax: (507) 284-1599; E-mail: bostwick.david@mayo.edu.
Received 10/30/97. Accepted 12/17/97.
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