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A Distinct Region of Chromosome 19p13.3 Associated with the Sporadic Form of Adenoma Malignum of the Uterine Cervix¹

Department of Pathology and Cancer Research Institute, Catholic University Medical College, Seoul 137-701 [J. Y. L., S. M. D., S. Y. K., E. Y. N., M. S. S., S. H. L., W. S. P., K. M. K., Y. S. L., N. J. Y.]; Department of Pathology, Sungkyunkwan University, College of Medicine, Seoul 100-380 [H. S. K.]; and Department of Pathology, Seoul National University College of Medicine and Cancer Research Center, Seoul 110-799 [J. J. J.]; Korea

Adenoma malignum (AM) is known to be one of the malignant tumors that is commonly associated with Peutz-Jeghers syndrome. Recently, the genetic locus of Peutz-Jeghers syndrome was mapped to the telomeric region of chromosome 19p. We analyzed nine sporadic cases of AM with high-density loss of heterozygosity to study the region of chromosome 19p13.2–13.3 using eight microsatellite markers. Our deletion mapping data revealed a distinct region with 100% loss of heterozygosity frequency at marker D19S216. This result indicates that a putative tumor suppressor gene for AM is located at D19S216 on chromosomal band 19p13.3 and plays an important role in AM tumorigenesis.

¹ Supported in part by the Catholic Medical Center Research Fund for special projects and by the Korea Science and Engineering Foundation through the Cancer Research Center at Seoul National University.

² To whom requests for reprints should be addressed, at the Department of Pathology, Catholic University Medical College, 505 Banpo-Dong, Socho-Gu, Seoul 137-701, Korea.

Received 12/ 2/97. Accepted 1/28/98.

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