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[Cancer Research 59, 35-43, January 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 35-43, January 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

A Novel Member of the NF2/ERM/4.1 Superfamily with Growth Suppressing Properties in Lung Cancer1

Yen K. Tran, Oliver Bögler, Karen M. Gorse, Ilse Wieland, Mark R. Green and Irene F. Newsham2

University of California–San Diego Cancer Center, University of California–San Diego, La Jolla, California 92093 [Y. K. T., I. F. N.]; Department of Anatomy, Medical College of Virginia Campus at Virginia Commonwealth University, Richmond, Virginia 23298 [O. B., K. M. G., I. F. N.]; Institut für Zellbiologie (Tumorforschung), Universitätsklinikum Essen, 45122 Essen, Germany [I. W.]; and Hollings Cancer Center, Medical College of South Carolina, Charleston, South Carolina 29425 [M. R. G.]

A novel putative tumor suppressor gene and member of the NF2/ERM/4.1 superfamily was isolated using Differential Display PCR (DDPCR) on primary lung tumors. When reintroduced into nonexpressing non-small cell lung carcinoma cell lines, this gene, named DAL-1 (for Differentially expressed in Adenocarcinoma of the Lung), was shown to suppress growth. In addition, significantly reduced expression (>50%) of DAL-1 was measured in 39 primary non-small cell lung carcinoma tumors as compared with patient-matched normal lung tissue. Immunocytochemical staining with a polyclonal anti-DAL-1 antibody localized the protein to the plasma membrane, particularly at cell-cell contact points, a pattern reminiscent of other members of the protein 4.1 superfamily including ezrin and NF2. The data suggest DAL-1 is a novel membrane-associated protein with potential to play an important role in the origin and progression of lung cancer.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
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Molecular Cancer Research Cancer Prevention Research
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Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.