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Advances in Brief |
Departments of Medicine [M. A. M.], Radiology [R. E. C., G. A., N. N.], and Surgery [H. K. L.] and Center for Genetic and Cellular Therapies [M. A. M., D. C., H. K. L.], Duke University Medical Center, Durham, North Carolina 27710
Present clinical studies of active immunotherapy for malignancies using dendritic cells (DCs) require elucidation of the sites where DCs localize after injection. We evaluated the pattern of distribution of in vitro-generated, antigen-loaded, human DCs labeled with indium-111 oxyquinoline after i.v., s.c., and intradermal injection. Whereas the DCs injected i.v. localized in the lungs and then redistributed to the liver, spleen, and bone marrow, they were not detected in lymph nodes or tumors. A small percentage of DCs injected intradermally migrated rapidly to the regional lymphatics in some individuals. No lymph node activity was detected after s.c. injection. Our results demonstrate that DC distribution to sites of lymphoid tissue is dramatically affected by the mode of administration.
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M. L. Disis, K. Rinn, K. L. Knutson, D. Davis, D. Caron, C. dela Rosa, and K. Schiffman Flt3 ligand as a vaccine adjuvant in association with HER-2/neu peptide-based vaccines in patients with HER-2/neu-overexpressing cancers Blood, April 15, 2002; 99(8): 2845 - 2850. [Abstract] [Full Text] [PDF]
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C. J. Kirk, D. Hartigan-O'Connor, and J. J. Mule The Dynamics of the T-Cell Antitumor Response: Chemokine-secreting Dendritic Cells Can Prime Tumor-reactive T Cells Extranodally Cancer Res., December 1, 2001; 61(24): 8794 - 8802. [Abstract] [Full Text] [PDF]
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M. THURNHER, C. ZELLE-RIESER, R. RAMONER, G. BARTSCH, and L. HOLTL The disabled dendritic cell FASEB J, April 1, 2001; 15(6): 1054 - 1061. [Abstract] [Full Text] [PDF]
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L. Fong, D. Brockstedt, C. Benike, L. Wu, and E. G. Engleman Dendritic Cells Injected Via Different Routes Induce Immunity in Cancer Patients J. Immunol., March 15, 2001; 166(6): 4254 - 4259. [Abstract] [Full Text] [PDF]
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C. J. Kirk, D. Hartigan-O’Connor, B. J. Nickoloff, J. S. Chamberlain, M. Giedlin, L. Aukerman, and J. J. Mulé T Cell-dependent Antitumor Immunity Mediated by Secondary Lymphoid Tissue Chemokine: Augmentation of Dendritic Cell-based Immunotherapy Cancer Res., March 1, 2001; 61(5): 2062 - 2070. [Abstract] [Full Text]
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L. A. Lambert, G. R. Gibson, M. Maloney, B. Durell, R. J. Noelle, and R. J. Barth Jr. Intranodal Immunization with Tumor Lysate-pulsed Dendritic Cells Enhances Protective Antitumor Immunity Cancer Res., January 1, 2001; 61(2): 641 - 646. [Abstract] [Full Text]
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 H. K. Lyerly, T. Clay, and M. A. Morse Optimizing Dendritic Cell Function by Genetic Modification J Natl Cancer Inst, August 2, 2000; 92(15): 1198 - 1199. [Full Text] [PDF]
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J. S. Serody, E. J. Collins2, R. M. Tisch, J. J. Kuhns, and J. A. Frelinger T Cell Activity After Dendritic Cell Vaccination Is Dependent on Both the Type of Antigen and the Mode of Delivery J. Immunol., May 1, 2000; 164(9): 4961 - 4967. [Abstract] [Full Text] [PDF]
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S. M. Barratt-Boyes, M. I. Zimmer, L. A. Harshyne, E. M. Meyer, S. C. Watkins, S. Capuano III, M. Murphey-Corb, L. D. Falo Jr., and A. D. Donnenberg Maturation and Trafficking of Monocyte-Derived Dendritic Cells in Monkeys: Implications for Dendritic Cell-Based Vaccines J. Immunol., March 1, 2000; 164(5): 2487 - 2495. [Abstract] [Full Text] [PDF]
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 R. Josien, H.-L. Li, E. Ingulli, S. Sarma, B. R.Wong, M. Vologodskaia, R. M. Steinman, and Y. Choi TRANCE, a Tumor Necrosis Factor Family Member, Enhances the Longevity and Adjuvant Properties of Dendritic Cells In Vivo J. Exp. Med., February 7, 2000; 191(3): 495 - 502. [Abstract] [Full Text] [PDF]
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S. S. Ahuja, R. L. Reddick, N. Sato, E. Montalbo, V. Kostecki, W. Zhao, M. J. Dolan, P. C. Melby, and S. K. Ahuja Dendritic Cell (DC)-Based Anti-Infective Strategies: DCs Engineered to Secrete IL-12 Are a Potent Vaccine in a Murine Model of an Intracellular Infection J. Immunol., October 1, 1999; 163(7): 3890 - 3897. [Abstract] [Full Text] [PDF]
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A. A. O. Eggert, M. W. J. Schreurs, O. C. Boerman, W. J. C. Oyen, A. J. de Boer, C. J. A. Punt, C. G. Figdor, and G. J. Adema Biodistribution and Vaccine Efficiency of Murine Dendritic Cells Are Dependent on the Route of Administration Cancer Res., July 1, 1999; 59(14): 3340 - 3345. [Abstract] [Full Text] [PDF]
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