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[Cancer Research 59, 63-66, January 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 63-66, January 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

The Identification of Monoclonality in Human Aberrant Crypt Foci1

I-Mei Siu, Dan R. Robinson, Stuart Schwartz, Hsing-Jien Kung, Thomas G. Pretlow, Robert B. Petersen and Theresa P. Pretlow2

Institute of Pathology [I-M. S., T. G. P., R. B. P., T. P. P.], Department of Molecular Biology and Microbiology [D. R. R., H-J. K.], and Department of Genetics [S. S.], Case Western Reserve University, Cleveland, Ohio 44106

Malignant neoplasms, including colon cancers, are thought to arise from a single initiated progenitor cell. Aberrant crypt foci (ACF) are putative precursors of at least some colon cancers. The pattern of X chromosomal inactivation, which is identified by the differential methylation of a site near a polymorphic CAG repeat in the androgen receptor gene, was used to determine the clonality status of 11 ACF from eight female patients. Ten of 11 ACF were found to be monoclonal aberrations. The eleventh ACF appeared monoclonal, but nonrandom inactivation of the X chromosome was also seen in normal crypts from this patient. These results clearly demonstrate that: (a) a high percentage of ACF lesions are neoplastic rather than hyperplastic; and (b) ACF are the earliest identified neoplastic lesions in the colon.




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Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
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Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.