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[Cancer Research 59, 2332-2334, May 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 2332-2334, May 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Association of Breast Cancer Progression with a Vitamin D Receptor Gene Polymorphism1

Anna-Carin Lundin, Peter Söderkvist, Birgitta Eriksson, Malin Bergman-Jungeström2, Sten Wingren2 and the South-East Sweden Breast Cancer Group,3

Divisions of Cell Biology [A-C. L., P. S., B. E.] and Oncology [M. B-J., S. W.], Department of Biomedicine and Surgery, Faculty of Health Sciences, S 581 85 Linköping, Sweden

The vitamin D3 receptor gene (VDR) contains a TaqI RFLP that is associated with increased VDR mRNA stability, increased serum levels of 1{alpha},25-dihydroxyvitamin D3 (1,25-D3), and decreased risk for prostate cancer. Determination of the TaqI genotype, in a group of young women with breast cancer (n = 111; age, <37 years) and a control population (n = 130), revealed no overall association to risk for breast cancer. However, patients without TaqI site (TT genotype) showed a significantly increased risk for lymph node metastasis (relative risk, 1.8, 95% confidence interval, 1.3–2.6). Furthermore, a tendency toward an increased survival was found among estrogen receptor-positive, tamoxifen-treated patients who were homozygous for the TaqI site (P = 0.075). We conclude that polymorphism in the VDR gene may influence tumor progression and tamoxifen treatment response in early-onset breast carcinomas.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.