Cancer Research The Future of Cancer Research: Science and Patient Impact Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 2532-2535, June 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hooijberg, J. H.
Right arrow Articles by Jansen, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hooijberg, J. H.
Right arrow Articles by Jansen, G.
[Cancer Research 59, 2532-2535, June 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Antifolate Resistance Mediated by the Multidrug Resistance Proteins MRP1 and MRP21

Jan Hendrik Hooijberg, Henk J. Broxterman, Marcel Kool, Yehuda G. Assaraf, Godefridus J. Peters, Paul Noordhuis, Rik J. Scheper, Piet Borst, Herbert M. Pinedo and Gerrit Jansen2

Departments of Medical Oncology [J. H. H., H. J. B., G. J. P., P. N., H. M. P., G. J.] and Pathology [R. J. S.], Academisch Ziekenhuis Vrije Universiteit, 1007 MB Amsterdam, the Netherlands; Department of Molecular Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands [M. K., P. B.]; and Department of Biology, The Technion, Israel Institute of Technology, Haifa 32000, Israel [Y. G. A.]

Transfection of multidrug resistance proteins (MRPs) MRP1 and MRP2 in human ovarian carcinoma 2008 cells conferred a marked level of resistance to short-term (1–4 h) exposure to the polyglutamatable antifolates methotrexate (MTX; 21–74-fold), ZD1694 (4–138-fold), and GW1843 (101–156-fold). Evidence for MRP-mediated antifolate efflux relies upon the following findings: (a) a 2–3.3-fold lower accumulation of [3H]MTX and subsequent reduced formation of long-chain polyglutamate forms of MTX; (b) reversal of MTX resistance by probenecid in both transfectants, and (c) ATP-dependent uptake of [3H]MTX in inside-out vesicles of MRP1 and MRP2 transfectants. This report provides a mechanistic basis for resistance to polyglutamatable antifolates through an MRP-mediated drug extrusion.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. Inoue, Y. Nakai, S. Ueda, S. Kamigaso, K.-y. Ohta, M. Hatakeyama, Y. Hayashi, M. Otagiri, and H. Yuasa
Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model
Am J Physiol Gastrointest Liver Physiol, March 1, 2008; 294(3): G660 - G668.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
S. L. Hider, I. N. Bruce, and W. Thomson
The pharmacogenetics of methotrexate
Rheumatology, October 1, 2007; 46(10): 1520 - 1524.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
R. Tahar and L. K. Basco
Molecular Epidemiology of Malaria in Cameroon. XXVI. Twelve-Year In Vitro and Molecular Surveillance of Pyrimethamine Resistance and Experimental Studies to Modulate Pyrimethamine Resistance
Am J Trop Med Hyg, August 1, 2007; 77(2): 221 - 227.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
P. Breedveld, D. Pluim, G. Cipriani, F. Dahlhaus, M. A. J. van Eijndhoven, C. J. F. de Wolf, A. Kuil, J. H. Beijnen, G. L. Scheffer, G. Jansen, et al.
The Effect of Low pH on Breast Cancer Resistance Protein (ABCG2)-Mediated Transport of Methotrexate, 7-Hydroxymethotrexate, Methotrexate Diglutamate, Folic Acid, Mitoxantrone, Topotecan, and Resveratrol in In Vitro Drug Transport Models
Mol. Pharmacol., January 1, 2007; 71(1): 240 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. S. Ray, T. Cihlar, K. L. Robinson, L. Tong, J. E. Vela, M. D. Fuller, L. M. Wieman, E. J. Eisenberg, and G. R. Rhodes
Mechanism of active renal tubular efflux of tenofovir.
Antimicrob. Agents Chemother., October 1, 2006; 50(10): 3297 - 3304.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
J. A. Seamon, C. A. Rugg, S. Emanuel, A. M. Calcagno, S. V. Ambudkar, S. A. Middleton, J. Butler, V. Borowski, and L. M. Greenberger
Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor.
Mol. Cancer Ther., October 1, 2006; 5(10): 2459 - 2467.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
S L Hider, A Owen, R Hartkoorn, S Khoo, D Back, A J Silman, and I N Bruce
Down regulation of multidrug resistance protein-1 expression in patients with early rheumatoid arthritis exposed to methotrexate as a first disease-modifying antirheumatic drug
Ann Rheum Dis, October 1, 2006; 65(10): 1390 - 1393.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
R. G. Deeley, C. Westlake, and S. P. C. Cole
Transmembrane Transport of Endo- and Xenobiotics by Mammalian ATP-Binding Cassette Multidrug Resistance Proteins.
Physiol Rev, July 1, 2006; 86(3): 849 - 899.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
A. Nzila
The past, present and future of antifolates in the treatment of Plasmodium falciparum infection
J. Antimicrob. Chemother., June 1, 2006; 57(6): 1043 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
S. Dallas, D. S. Miller, and R. Bendayan
Multidrug resistance-associated proteins: expression and function in the central nervous system.
Pharmacol. Rev., June 1, 2006; 58(2): 140 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
L. Couture, J. A. Nash, and J. Turgeon
The ATP-Binding Cassette Transporters and Their Implication in Drug Disposition: A Special Look at the Heart.
Pharmacol. Rev., June 1, 2006; 58(2): 244 - 258.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
J. P. Leader and M. J. O'Donnell
Transepithelial transport of fluorescent p-glycoprotein and MRP2 substrates by insect Malpighian tubules: confocal microscopic analysis of secreted fluid droplets
J. Exp. Biol., December 1, 2005; 208(23): 4363 - 4376.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
H. Dai, Y. Chen, and W. F. Elmquist
Distribution of the Novel Antifolate Pemetrexed to the Brain
J. Pharmacol. Exp. Ther., October 1, 2005; 315(1): 222 - 229.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Shafran, I. Ifergan, E. Bram, G. Jansen, I. Kathmann, G. J. Peters, R. W. Robey, S. E. Bates, and Y. G. Assaraf
ABCG2 Harboring the Gly482 Mutation Confers High-Level Resistance to Various Hydrophilic Antifolates
Cancer Res., September 15, 2005; 65(18): 8414 - 8422.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Wielinga, J. H. Hooijberg, S. Gunnarsdottir, I. Kathmann, G. Reid, N. Zelcer, K. van der Born, M. de Haas, I. van der Heijden, G. Kaspers, et al.
The Human Multidrug Resistance Protein MRP5 Transports Folates and Can Mediate Cellular Resistance against Antifolates
Cancer Res., May 15, 2005; 65(10): 4425 - 4430.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J Wolf, T Stranzl, M Filipits, G Pohl, R Pirker, B Leeb, and J S Smolen
Expression of resistance markers to methotrexate predicts clinical improvement in patients with rheumatoid arthritis
Ann Rheum Dis, April 1, 2005; 64(4): 564 - 568.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. Filipits, G. Pohl, M. Rudas, O. Dietze, S. Lax, R. Grill, R. Pirker, C. C. Zielinski, H. Hausmaninger, E. Kubista, et al.
Clinical Role of Multidrug Resistance Protein 1 Expression in Chemotherapy Resistance in Early-Stage Breast Cancer: The Austrian Breast and Colorectal Cancer Study Group
J. Clin. Oncol., February 20, 2005; 23(6): 1161 - 1168.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Liu, Y. Ge, D. C. Cabelof, A. Aboukameel, A. R. Heydari, R. Mohammad, and L. H. Matherly
Structure and Regulation of the Murine Reduced Folate Carrier Gene: IDENTIFICATION OF FOUR NONCODING EXONS AND PROMOTERS AND REGULATION BY DIETARY FOLATES
J. Biol. Chem., February 18, 2005; 280(7): 5588 - 5597.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Z.-S. Chen, Y. Guo, M. G. Belinsky, E. Kotova, and G. D. Kruh
Transport of Bile Acids, Sulfated Steroids, Estradiol 17-{beta}-D-Glucuronide, and Leukotriene C4 by Human Multidrug Resistance Protein 8 (ABCC11)
Mol. Pharmacol., February 1, 2005; 67(2): 545 - 557.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Fotoohi, G. Jansen, Y. G. Assaraf, L. Rothem, M. Stark, I. Kathmann, J. Gregorczyk, G. J. Peters, and F. Albertioni
Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy
Blood, December 15, 2004; 104(13): 4194 - 4201.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
P. Breedveld, N. Zelcer, D. Pluim, O. Sonmezer, M. M. Tibben, J. H. Beijnen, A. H. Schinkel, O. van Tellingen, P. Borst, and J. H. M. Schellens
Mechanism of the Pharmacokinetic Interaction between Methotrexate and Benzimidazoles: Potential Role for Breast Cancer Resistance Protein in Clinical Drug-Drug Interactions
Cancer Res., August 15, 2004; 64(16): 5804 - 5811.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. Ifergan, A. Shafran, G. Jansen, J. H. Hooijberg, G. L. Scheffer, and Y. G. Assaraf
Folate Deprivation Results in the Loss of Breast Cancer Resistance Protein (BCRP/ABCG2) Expression: A ROLE FOR BCRP IN CELLULAR FOLATE HOMEOSTASIS
J. Biol. Chem., June 11, 2004; 279(24): 25527 - 25534.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. Desjardins, D. L. Emerson, D. B. Colagiovanni, E. Abbott, E. N. Brown, and D. W. Drolet
Pharmacokinetics, Safety, and Efficacy of a Liposome Encapsulated Thymidylate Synthase Inhibitor, OSI-7904L [(S)-2-[5-[(1,2-Dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric Acid] in Mice
J. Pharmacol. Exp. Ther., June 1, 2004; 309(3): 894 - 902.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Koike, G. Conseil, E. M. Leslie, R. G. Deeley, and S. P. C. Cole
Identification of Proline Residues in the Core Cytoplasmic and Transmembrane Regions of Multidrug Resistance Protein 1 (MRP1/ABCC1) Important for Transport Function, Substrate Specificity, and Nucleotide Interactions
J. Biol. Chem., March 26, 2004; 279(13): 12325 - 12336.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J van der Heijden, M C de Jong, B A C Dijkmans, W F Lems, R Oerlemans, I Kathmann, G L Scheffer, R J Scheper, Y G Assaraf, and G Jansen
Acquired resistance of human T cells to sulfasalazine: stability of the resistant phenotype and sensitivity to non-related DMARDs
Ann Rheum Dis, February 1, 2004; 63(2): 131 - 137.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J van der Heijden, M C de Jong, B A C Dijkmans, W F Lems, R Oerlemans, I Kathmann, C G Schalkwijk, G L Scheffer, R J Scheper, and G Jansen
Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNF{alpha}
Ann Rheum Dis, February 1, 2004; 63(2): 138 - 143.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
C G Dietrich, A Geier, and R P J Oude Elferink
ABC of oral bioavailability: transporters as gatekeepers in the gut
Gut, December 1, 2003; 52(12): 1788 - 1795.
[Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. C. de Jong, G. L. Scheffer, H. J. Broxterman, J. H. Hooijberg, J. W. Slootstra, R. H. Meloen, R. J. Kreitman, S. R. Husain, B. H. Joshi, R. K. Puri, et al.
Multidrug-Resistant Tumor Cells Remain Sensitive to a Recombinant Interleukin-4-Pseudomonas Exotoxin, Except When Overexpressing the Multidrug Resistance Protein MRP1
Clin. Cancer Res., October 15, 2003; 9(13): 5009 - 5017.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. L. Volk and E. Schneider
Wild-Type Breast Cancer Resistance Protein (BCRP/ABCG2) is a Methotrexate Polyglutamate Transporter
Cancer Res., September 1, 2003; 63(17): 5538 - 5543.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. Stark, L. Rothem, G. Jansen, G. L. Scheffer, I. D. Goldman, and Y. G. Assaraf
Antifolate Resistance Associated with Loss of MRP1 Expression and Function in Chinese Hamster Ovary Cells with Markedly Impaired Export of Folate and Cholate
Mol. Pharmacol., August 1, 2003; 64(2): 220 - 227.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Z.-S. Chen, R. W. Robey, M. G. Belinsky, I. Shchaveleva, X.-Q. Ren, Y. Sugimoto, D. D. Ross, S. E. Bates, and G. D. Kruh
Transport of Methotrexate, Methotrexate Polyglutamates, and 17{beta}-Estradiol 17-({beta}-D-glucuronide) by ABCG2: Effects of Acquired Mutations at R482 on Methotrexate Transport
Cancer Res., July 15, 2003; 63(14): 4048 - 4054.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. Nzila, E. Mberu, P. Bray, G. Kokwaro, P. Winstanley, K. Marsh, and S. Ward
Chemosensitization of Plasmodium falciparum by Probenecid In Vitro
Antimicrob. Agents Chemother., July 1, 2003; 47(7): 2108 - 2112.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
A. C. Lockhart, R. G. Tirona, and R. B. Kim
Pharmacogenetics of ATP-binding Cassette Transporters in Cancer and Chemotherapy
Mol. Cancer Ther., July 1, 2003; 2(7): 685 - 698.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Konno, T. Ebihara, K. Hisaeda, T. Uchiumi, T. Nakamura, T. Shirakusa, M. Kuwano, and M. Wada
Identification of Domains Participating in the Substrate Specificity and Subcellular Localization of the Multidrug Resistance Proteins MRP1 and MRP2
J. Biol. Chem., June 13, 2003; 278(25): 22908 - 22917.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
S L Hider, C Morgan, E Bell, I N Bruce, P Ranganathan, and H L McLeod
Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with RA?
Ann Rheum Dis, June 1, 2003; 62(6): 591 - 591.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. G. Assaraf, L. Rothem, J. H. Hooijberg, M. Stark, I. Ifergan, I. Kathmann, B. A. C. Dijkmans, G. J. Peters, and G. Jansen
Loss of Multidrug Resistance Protein 1 Expression and Folate Efflux Activity Results in a Highly Concentrative Folate Transport in Human Leukemia Cells
J. Biol. Chem., February 21, 2003; 278(9): 6680 - 6686.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
E. M. Leslie, R. J. Bowers, R. G. Deeley, and S. P. C. Cole
Structural Requirements for Functional Interaction of Glutathione Tripeptide Analogs with the Human Multidrug Resistance Protein 1 (MRP1)
J. Pharmacol. Exp. Ther., February 1, 2003; 304(2): 643 - 653.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. J. Zamek-Gliszczynski, H. Xiong, N. J. Patel, R. Z. Turncliff, G. M. Pollack, and K. L. R. Brouwer
Pharmacokinetics of 5 (and 6)-Carboxy-2',7'-Dichlorofluorescein and Its Diacetate Promoiety in the Liver
J. Pharmacol. Exp. Ther., February 1, 2003; 304(2): 801 - 809.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
P Ranganathan, S Eisen, W M Yokoyama, and H L McLeod
Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis?
Ann Rheum Dis, January 1, 2003; 62(1): 4 - 9.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Koike, C. J. Oleschuk, A. Haimeur, S. L. Olsen, R. G. Deeley, and S. P. C. Cole
Multiple Membrane-associated Tryptophan Residues Contribute to the Transport Activity and Substrate Specificity of the Human Multidrug Resistance Protein, MRP1
J. Biol. Chem., December 13, 2002; 277(51): 49495 - 49503.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Ohishi, Y. Oda, T. Uchiumi, H. Kobayashi, T. Hirakawa, S. Miyamoto, N. Kinukawa, H. Nakano, M. Kuwano, and M. Tsuneyoshi
ATP-binding Cassette Superfamily Transporter Gene Expression in Human Primary Ovarian Carcinoma
Clin. Cancer Res., December 1, 2002; 8(12): 3767 - 3775.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
C.M.F. Kruijtzer, J.H. Beijnen, and J.H.M. Schellens
Improvement of Oral Drug Treatment by Temporary Inhibition of Drug Transporters and/or Cytochrome P450 in the Gastrointestinal Tract and Liver: An Overview
Oncologist, December 1, 2002; 7(6): 516 - 530.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. G. Belinsky, Z.-S. Chen, I. Shchaveleva, H. Zeng, and G. D. Kruh
Characterization of the Drug Resistance and Transport Properties of Multidrug Resistance Protein 6 (MRP6, ABCC6)
Cancer Res., November 1, 2002; 62(21): 6172 - 6177.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
D. Burg, P. Wielinga, N. Zelcer, T. Saeki, G. J. Mulder, and P. Borst
Inhibition of the Multidrug Resistance Protein 1 (MRP1) by Peptidomimetic Glutathione-Conjugate Analogs
Mol. Pharmacol., November 1, 2002; 62(5): 1160 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Haimeur, R. G. Deeley, and S. P. C. Cole
Charged Amino Acids in the Sixth Transmembrane Helix of Multidrug Resistance Protein 1 (MRP1/ABCC1) Are Critical Determinants of Transport Activity
J. Biol. Chem., October 25, 2002; 277(44): 41326 - 41333.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Z. P. Lin, D. R. Johnson, R. A. Finch, M. G. Belinsky, G. D. Kruh, and A. C. Sartorelli
Comparative Study of the Importance of Multidrug Resistance-associated Protein 1 and P-Glycoprotein to Drug Sensitivity in Immortalized Mouse Embryonic Fibroblasts
Mol. Cancer Ther., October 1, 2002; 1(12): 1105 - 1114.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
E. L. Volk, K. M. Farley, Y. Wu, F. Li, R. W. Robey, and E. Schneider
Overexpression of Wild-Type Breast Cancer Resistance Protein Mediates Methotrexate Resistance
Cancer Res., September 1, 2002; 62(17): 5035 - 5040.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Takeda, S. Khamdang, S. Narikawa, H. Kimura, M. Hosoyamada, S. H. Cha, T. Sekine, and H. Endou
Characterization of Methotrexate Transport and Its Drug Interactions with Human Organic Anion Transporters
J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 666 - 671.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
Z.-S. Chen, K. Lee, S. Walther, R. B. Raftogianis, M. Kuwano, H. Zeng, and G. D. Kruh
Analysis of Methotrexate and Folate Transport by Multidrug Resistance Protein 4 (ABCC4): MRP4 Is a Component of the Methotrexate Efflux System
Cancer Res., June 1, 2002; 62(11): 3144 - 3150.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D.-W. Zhang, S. P. C. Cole, and R. G. Deeley
Determinants of the Substrate Specificity of Multidrug Resistance Protein 1. ROLE OF AMINO ACID RESIDUES WITH HYDROGEN BONDING POTENTIAL IN PREDICTED TRANSMEMBRANE HELIX 17
J. Biol. Chem., May 31, 2002; 277(23): 20934 - 20941.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
W. Loscher and H. Potschka
Role of Multidrug Transporters in Pharmacoresistance to Antiepileptic Drugs
J. Pharmacol. Exp. Ther., April 1, 2002; 301(1): 7 - 14.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. Rajgopal, E. E. Sierra, R. Zhao, and I. D. Goldman
Expression of the reduced folate carrier SLC19A1 in IEC-6 cells results in two distinct transport activities
Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1579 - C1586.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Worm, A. F. Kirkin, K. N. Dzhandzhugazyan, and P. Guldberg
Methylation-dependent Silencing of the Reduced Folate Carrier Gene in Inherently Methotrexate-resistant Human Breast Cancer Cells
J. Biol. Chem., October 19, 2001; 276(43): 39990 - 40000.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Zeng, Z.-S. Chen, M. G. Belinsky, P. A. Rea, and G. D. Kruh
Transport of Methotrexate (MTX) and Folates by Multidrug Resistance Protein (MRP) 3 and MRP1: Effect of Polyglutamylation on MTX Transport
Cancer Res., October 1, 2001; 61(19): 7225 - 7232.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Z. Khokhar, Y. She, V. W. Rusch, and F. M. Sirotnak
Experimental Therapeutics with a New 10-Deazaaminopterin in Human Mesothelioma: Further Improving Efficacy through Structural Design, Pharmacologic Modulation at the Level of MRP ATPases, and Combined Therapy with Platinums
Clin. Cancer Res., October 1, 2001; 7(10): 3199 - 3205.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. C. Young, B. G. Campling, S. P. C. Cole, R. G. Deeley, and J. H. Gerlach
Multidrug Resistance Proteins MRP3, MRP1, and MRP2 in Lung Cancer: Correlation of Protein Levels with Drug Response and Messenger RNA Levels
Clin. Cancer Res., June 1, 2001; 7(6): 1798 - 1804.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C. G. Dietrich, D. R. de Waart, R. Ottenhoff, I. G. Schoots, and R. P. J. O. Elferink
Increased Bioavailability of the Food-Derived Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-Deficient Rats
Mol. Pharmacol., April 16, 2001; 59(5): 974 - 980.
[Abstract] [Full Text]

Home page
 Mol. Pharmacol.Home page
E. M. Leslie, Q. Mao, C. J. Oleschuk, R. G. Deeley, and S. P. C. Cole
Modulation of Multidrug Resistance Protein 1 (MRP1/ABCC1) Transport and ATPase Activities by Interaction with Dietary Flavonoids
Mol. Pharmacol., April 16, 2001; 59(5): 1171 - 1180.
[Abstract] [Full Text]

Home page
 JNCI J Natl Cancer InstHome page
K. Lee, A. J. P. Klein-Szanto, and G. D. Kruh
Analysis of the MRP4 Drug Resistance Profile in Transfected NIH3T3 Cells
J Natl Cancer Inst, December 6, 2000; 92(23): 1934 - 1940.
[Abstract] [Full Text] [PDF]