This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schorr, K. Articles by Furth, P. A. Search for Related Content PubMed PubMed Citation Articles by Schorr, K. Articles by Furth, P. A.

Gain of Bcl-2 Is More Potent Than Bax Loss in Regulating Mammary Epithelial Cell Survival in Vivo¹

Department of Physiology [K. S., P. A. F.] and Institute of Human Virology and Division of Infectious Disease, Department of Medicine [M. L., U. B-P., A. L., A. H., B. L., P. A. F.], University of Maryland Medical School, Baltimore, Maryland 21201; Howard Hughes Medical Institute and Division of Molecular Oncology, Departments of Medicine and Pathology, Washington University School of Medicine, St. Louis, Missouri 63110 [C. M. K., S. J. K.]; Forschungszentrum Karlsruhe, Institut fuer Genetik, Postfach 3640, 76021 Karlsruhe, Germany [R. J.]; and Institut fuer Diabetesforschung, Koelner Platz 1, 80804 Munich, Germany [H. W.]

The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell survival 70% during the second stage. Complete loss of Bax reduced apoptosis by 20% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo.

This article has been cited by other articles:

				L. Zhao, J. J. Melenhorst, and L. Hennighausen Loss of Interleukin 6 Results in Delayed Mammary Gland Involution: A Possible Role for Mitogen-Activated Protein Kinase and Not Signal Transducer and Activator of Transcription 3 Mol. Endocrinol., December 1, 2002; 16(12): 2902 - 2912. [Abstract] [Full Text] [PDF]

				S. S. Martin and P. Leder Human MCF10A Mammary Epithelial Cells Undergo Apoptosis following Actin Depolymerization That Is Independent of Attachment and Rescued by Bcl-2 Mol. Cell. Biol., October 1, 2001; 21(19): 6529 - 6536. [Abstract] [Full Text] [PDF]

				A. Shilkaitis, J. Graves, R. R. Mehta, L. Hu, M. You, R. Lubet, V. Steele, G. Kelloff, and K. Christov Bcl-2 and Bax Are Differentially Expressed in Hyperplastic, Premalignant, and Malignant Lesions of Mammary Carcinogenesis Cell Growth Differ., August 1, 2000; 11(8): 437 - 445. [Abstract] [Full Text]

				A. Nguyen and J. Pollard Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution Development, January 7, 2000; 127(14): 3107 - 3118. [Abstract] [PDF]