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Bone Marrow Pre-B-1 (Bomb1): A Quantitative Trait Locus Inducing Bone Marrow Pre-B-Cell Expansion in Lymphoma-prone SL/Kh Mice¹

Department of Pathology and Biology of Diseases, Kyoto University Graduate School of Medicine, Kyoto 606-8501 [L-M. L., R. S., S. H., Z. Z., H. H.]; and Department of Pathology, Faculty of Medicine, Ehime University, Ehime 791-0295 [L-M. L.], Japan

Abnormalities of regulatory genes in early B-cell development often lead to lymphomagenesis. Our previous study showed that there is an abnormal transient expansion of bone marrow (BM) pre-B cells in lymphoma-prone SL/Kh strain mice. Such expansion is a genetic property of SL/Kh stem cells rather than BM microenvironments. Using the percentage of BP1⁺B220⁺ pre-B cells in total BM lymphoid cells as a quantitative parameter, we studied the genetic control of BM pre-B cells in 159 F₂ offspring of crosses between SL/Kh and NFS/N mice and 334 back-crosses to SL/Kh mice. A highly significant quantitative trait locus was identified on the distal segment of chromosome 3, showing logarithm of odds scores of 22.7 in the F₂ cohort and 10.7 in back-cross mice. This quantitative trait locus, named bone marrow pre-B-1, colocalized with lymphoid enhancer factor-1, which encodes a high mobility group DNA-binding protein that is expressed in T and pre-B cells.

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