| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Tumor Biology |
Vß3 Promotes M21 Melanoma Growth in Human Skin by Regulating Tumor Cell Survival1
University of Southern California School of Medicine, Department of Biochemistry and Molecular Biology, Norris Cancer Center, Los Angeles, California 90033 [E. P., P. C. B.]; Department of Immunology, Pathology, Microbiology, and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, SE-14186 Huddinge, Sweden [S. S.]; Department of Immunology, The Scripps Research Institute, La Jolla, California 92037 [T. L. v. S., A. M. P. M., D. A. C.]; and Merck Farma y Quimica, Laboratorio de Bioinvestigacion, Barcelona, Spain [F. M., J. P.]
Growth and dissemination of malignant melanoma has a profound impact on our population, and little is known concerning the mechanisms controlling this disease in humans. Evidence is provided that integrin 
Vß3 plays a critical role in M21 melanoma tumor survival within human skin by a mechanism independent of its known role in angiogenesis. Antagonists of Vß3 blocked melanoma growth by inducing tumor apoptosis. Moreover, M21 melanoma cell interactions with denatured collagen, a known ligand for Vß3, caused a 5-fold increase in the relative Bcl-2:Bax ratio, an event thought to promote cell survival. Importantly, denatured collagen colocalized with Vß3-expressing melanoma cells in human tumor biopsies, suggesting that Vß3 interaction with denatured collagen may play a critical role in melanoma tumor survival in vivo.
This article has been cited by other articles:
|
|
 |
|
  O. ENGEBRAATEN, M. TRIKHA, S. JUELL, S. GARMAN-VIK, and O. FODSTAD Inhibition of In Vivo Tumour Growth by the Blocking of Host {alpha}v{beta}3 and {alpha}IIb{beta}3 Integrins Anticancer Res, January 1, 2009; 29(1): 131 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Conti, T. J. Kendall, A. Bateman, T. A. Armstrong, A. Papa-Adams, Q. Xu, G. Packham, J. N. Primrose, R. C. Benyon, and J. P. Iredale The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via {alpha}v Integrin Ligation Clin. Cancer Res., October 15, 2008; 14(20): 6405 - 6413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cretu, J. M. Roth, M. Caunt, A. Akalu, D. Policarpio, S. Formenti, P. Gagne, L. Liebes, and P. C. Brooks Disruption of Endothelial Cell Interactions with the Novel HU177 Cryptic Collagen Epitope Inhibits Angiogenesis Clin. Cancer Res., May 15, 2007; 13(10): 3068 - 3078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Akalu, J. M. Roth, M. Caunt, D. Policarpio, L. Liebes, and P. C. Brooks Inhibition of Angiogenesis and Tumor Metastasis by Targeting a Matrix Immobilized Cryptic Extracellular Matrix Epitope in Laminin Cancer Res., May 1, 2007; 67(9): 4353 - 4363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhou, A. Jamil, A. Nash, J. Chan, N. Trim, J. P. Iredale, and R. C. Benyon Impaired Proteolysis of Collagen I Inhibits Proliferation of Hepatic Stellate Cells: IMPLICATIONS FOR REGULATION OF LIVER FIBROSIS J. Biol. Chem., December 29, 2006; 281(52): 39757 - 39765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Le Boeuf, F. Houle, M. Sussman, and J. Huot Phosphorylation of Focal Adhesion Kinase (FAK) on Ser732 Is Induced by Rho-dependent Kinase and Is Essential for Proline-rich Tyrosine Kinase-2-mediated Phosphorylation of FAK on Tyr407 in Response to Vascular Endothelial Growth Factor Mol. Biol. Cell, August 1, 2006; 17(8): 3508 - 3520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Miller and M. C. Mihm Jr. Melanoma. N. Engl. J. Med., July 6, 2006; 355(1): 51 - 65. [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Roth, M. Caunt, A. Cretu, A. Akalu, D. Policarpio, X. Li, P. Gagne, S. Formenti, and P. C. Brooks Inhibition of Experimental Metastasis by Targeting the HUIV26 Cryptic Epitope in Collagen Am. J. Pathol., May 1, 2006; 168(5): 1576 - 1586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Nisato, G. Hosseini, C. Sirrenberg, G. S. Butler, T. Crabbe, A. J.P. Docherty, M. Wiesner, G. Murphy, C. M. Overall, S. L. Goodman, et al. Dissecting the Role of Matrix Metalloproteinases (MMP) and Integrin {alpha}v{beta}3 in Angiogenesis In vitro: Absence of Hemopexin C Domain Bioactivity, but Membrane-Type 1-MMP and {alpha}v{beta}3 Are Critical Cancer Res., October 15, 2005; 65(20): 9377 - 9387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Courter, L. Lomas, M. Scatena, and C. M. Giachelli Src Kinase Activity Is Required for Integrin {alpha}V{beta}3-Mediated Activation of Nuclear Factor-{kappa}B J. Biol. Chem., April 1, 2005; 280(13): 12145 - 12151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Roth, A. Akalu, A. Zelmanovich, D. Policarpio, B. Ng, S. MacDonald, S. Formenti, L. Liebes, and P. C. Brooks Recombinant {alpha}2(IV)NC1 Domain Inhibits Tumor Cell-Extracellular Matrix Interactions, Induces Cellular Senescence, and Inhibits Tumor Growth in Vivo Am. J. Pathol., March 1, 2005; 166(3): 901 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Bao and S. Stromblad Integrin {alpha}v-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen J. Cell Biol., November 22, 2004; 167(4): 745 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Beauvais, B. J. Burbach, and A. C. Rapraeger The syndecan-1 ectodomain regulates {alpha}v{beta}3 integrin activity in human mammary carcinoma cells J. Cell Biol., October 11, 2004; 167(1): 171 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Le Boeuf, F. Houle, and J. Huot Regulation of Vascular Endothelial Growth Factor Receptor 2-mediated Phosphorylation of Focal Adhesion Kinase by Heat Shock Protein 90 and Src Kinase Activities J. Biol. Chem., September 10, 2004; 279(37): 39175 - 39185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Silletti, M. Yebra, B. Perez, V. Cirulli, M. McMahon, and A. M. P. Montgomery Extracellular Signal-regulated Kinase (ERK)-dependent Gene Expression Contributes to L1 Cell Adhesion Molecule-dependent Motility and Invasion J. Biol. Chem., July 9, 2004; 279(28): 28880 - 28888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Petitclerc, R. G. Deschesnes, M.-F. Cote, C. Marquis, R. Janvier, J. Lacroix, E. Miot-Noirault, J. Legault, E. Mounetou, J.-C. Madelmont, et al. Antiangiogenic and Antitumoral Activity of Phenyl-3-(2-Chloroethyl)Ureas: A Class of Soft Alkylating Agents Disrupting Microtubules That Are Unaffected by Cell Adhesion-Mediated Drug Resistance Cancer Res., July 1, 2004; 64(13): 4654 - 4663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhou, F. R. Murphy, N. Gehdu, J. Zhang, J. P. Iredale, and R. C. Benyon Engagement of {alpha}v{beta}3 Integrin Regulates Proliferation and Apoptosis of Hepatic Stellate Cells J. Biol. Chem., June 4, 2004; 279(23): 23996 - 24006. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Chhokar and A. L. Tucker Angiogenesis: Basic Mechanisms and Clinical Applications Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 253 - 280. [Abstract] [PDF]
|
|
|
|
|
|
G. P. Pidgeon, K. Tang, Y. L. Cai, E. Piasentin, and K. V. Honn Overexpression of Platelet-type 12-Lipoxygenase Promotes Tumor Cell Survival by Enhancing {alpha}v{beta}3 and {alpha}v{beta}5 Integrin Expression Cancer Res., July 15, 2003; 63(14): 4258 - 4267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Burbridge, V. Venot, P. J. Casara, F. Perron-Sierra, J. A. Hickman, and G. C. Tucker Decrease in Survival Threshold of Quiescent Colon Carcinoma Cells in the Presence of a Small Molecule Integrin Antagonist Mol. Pharmacol., June 1, 2003; 63(6): 1281 - 1288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Govindarajan, X. Bai, C. Cohen, H. Zhong, S. Kilroy, G. Louis, M. Moses, and J. L Arbiser Malignant Transformation of Melanocytes to Melanoma by Constitutive Activation of Mitogen-activated Protein Kinase Kinase (MAPKK) Signaling J. Biol. Chem., March 7, 2003; 278(11): 9790 - 9795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Wang, B. J. Manning, Q. D. Wu, S. Blankson, D. Bouchier-Hayes, and H. P. Redmond Endotoxin/Lipopolysaccharide Activates NF-{kappa}B and Enhances Tumor Cell Adhesion and Invasion Through a {beta}1 Integrin-Dependent Mechanism J. Immunol., January 15, 2003; 170(2): 795 - 804. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hangai, N. Kitaya, J. Xu, C. K. Chan, J. J. Kim, Z. Werb, S. J. Ryan, and P. C. Brooks Matrix Metalloproteinase-9-Dependent Exposure of a Cryptic Migratory Control Site in Collagen is Required before Retinal Angiogenesis Am. J. Pathol., October 1, 2002; 161(4): 1429 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Geissinger, C. Weisser, P. Fischer, M. Schartl, and C. Wellbrock Autocrine Stimulation by Osteopontin Contributes to Antiapoptotic Signalling of Melanocytes in Dermal Collagen Cancer Res., August 15, 2002; 62(16): 4820 - 4828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Wahl, J. A. Owen, R. Burd, R. A. Herlands, S. S. Nogami, U. Rodeck, D. Berd, D. B. Leeper, and C. S. Owen Regulation of Intracellular pH in Human Melanoma: Potential Therapeutic Implications Mol. Cancer Ther., June 1, 2002; 1(8): 617 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Stupack and D. A. Cheresh Get a ligand, get a life: integrins, signaling and cell survival J. Cell Sci., January 10, 2002; 115(19): 3729 - 3738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Sturm, K. Satyamoorthy, F. Meier, B. B. Gardiner, D. J. Smit, B. Vaidya, and M. Herlyn Osteonectin/SPARC Induction by Ectopic {beta}3 Integrin in Human Radial Growth Phase Primary Melanoma Cells Cancer Res., January 1, 2002; 62(1): 226 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xu, D. Rodriguez, E. Petitclerc, J. J. Kim, M. Hangai, S. M. Yuen, G. E. Davis, and P. C. Brooks Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo J. Cell Biol., September 3, 2001; 154(5): 1069 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Brummer, A. Ebrahimnejad, R. Flayeh, U. Schumacher, T. Loning, A.-M. Bamberger, and C. Wagener cis Interaction of the Cell Adhesion Molecule CEACAM1 with Integrin {beta}3 Am. J. Pathol., August 1, 2001; 159(2): 537 - 546. [Abstract] [Full Text]
|
|
|
|
|
|
C. C. Kumar, M. Malkowski, Z. Yin, E. Tanghetti, B. Yaremko, T. Nechuta, J. Varner, M. Liu, E. M. Smith, B. Neustadt, et al. Inhibition of Angiogenesis and Tumor Growth by SCH221153, a Dual {{alpha}}v{beta}3 and {{alpha}}v{beta}5 Integrin Receptor Antagonist Cancer Res., March 1, 2001; 61(5): 2232 - 2238. [Abstract] [Full Text]
|
|
|
|
|
|
O. Salvucci, M. Carsana, I. Bersani, G. Tragni, and A. Anichini Antiapoptotic Role of Endogenous Nitric Oxide in Human Melanoma Cells Cancer Res., January 1, 2001; 61(1): 318 - 326. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Maeshima, P. C. Colorado, and R. Kalluri Two RGD-independent alpha vbeta 3 Integrin Binding Sites on Tumstatin Regulate Distinct Anti-tumor Properties J. Biol. Chem., July 28, 2000; 275(31): 23745 - 23750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-Q. Zheng, A. S. Woodard, G. Tallini, and L. R. Languino Substrate Specificity of alpha vbeta 3 Integrin-mediated Cell Migration and Phosphatidylinositol 3-Kinase/AKT Pathway Activation J. Biol. Chem., August 4, 2000; 275(32): 24565 - 24574. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. McMahon, E. Petitclerc, S. Stefansson, E. Smith, M. K. K. Wong, R. J. Westrick, D. Ginsburg, P. C. Brooks, and D. A. Lawrence Plasminogen Activator Inhibitor-1 Regulates Tumor Growth and Angiogenesis J. Biol. Chem., August 31, 2001; 276(36): 33964 - 33968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Henriet, Z.-D. Zhong, P. C. Brooks, K. I. Weinberg, and Y. A. DeClerck Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1 PNAS, August 29, 2000; 97(18): 10026 - 10031. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
