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[Cancer Research 59, 2781-2786, June 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 2781-2786, June 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

The Transcriptional Activities of p53 and Its Homologue p51/p63: Similaritiesand Differences1

Akira Shimada, Shunsuke Kato, Kentaro Enjo, Motonobu Osada, Yoji Ikawa, Kenji Kohno, Masuo Obinata, Ryunosuke Kanamaru, Shuntaro Ikawa and Chikashi Ishioka2

Departments of Clinical Oncology [A. S., S. K., R. K., C. I.] and Cell Biology [K. E., M. Os., M. Ob., S. I.], Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575; Department of Retroviral Regulation, Tokyo Medical and Dental University, Medical Research Division, Tokyo 113-8519 [Y. I.]; and Nara Institute of Science and Technology, Nara 630-01 [K. K.], Japan

p51/p63 is a novel p53 homologue that has been shown to act as a transcriptional activator through the p53-binding sequence of the p21/WAF1 promoter and to induce apoptosis when it is expressed transiently in a human tumor cell line. We developed transcription assay systems for these two related genes in both Saccharomyces cerevisiae and mammalian cells and used them to investigate the functional similarities and differences of these genes. We found that p51/p63 trans-activated the previously identified p53 target genes, but the degree of the transactivation by p51/p63 differed from that by p53. These results suggest that the cellular signal on p51/p63 cross-talks partially but not completely with that of the p53 pathway.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.