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Identification of a Region of Frequent Loss of Heterozygosity at 11q24 in Colorectal Cancer

Imperial Cancer Research Fund Medical Oncology Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU [K. C. C., H. G., K. J. T., G. R., J. E. V. W., J. F. S., D. I. J.], and Cancer Research Campaign, Department of Pathology, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG [C. J. M., A. H. W.], Scotland, United Kingdom

Loss of heterozygosity (LOH) at 11q23–qter occurs frequently in ovarian and other cancers, but for colorectal cancer, the evidence is conflicting. Seven polymorphic loci were analyzed between D11S897 and D11S969 in 50 colorectal tumors. Two distinct LOH regions were detected, suggesting possible sites for tumor-suppressor genes involved in colorectal neoplasia: a large centromeric region between D11S897 and D11S925, and a telomeric 4.9-Mb region between D11S912 and D11S969. There was no correlation with clinicopathological features. This analysis describes a region of LOH in the region 11q23.3–24.3 for the first time in colorectal cancer and provides complementary evidence for the ongoing effort to identify the gene(s) involved.

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