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[Cancer Research 59, 2825-2828, June 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 2825-2828, June 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

CYP17 and Breast Cancer Risk

The Polymorphism in the 5' Flanking Area of the Gene Does Not Influence Binding to Sp-11

Vessela Nedelcheva Kristensen2, Ellen K. Haraldsen, Kristin B. Anderson, P. E. Lønning, Bjørn Erikstein, Rolf Kåresen, Odd S. Gabrielsen and Anne-Lise Børresen-Dale

Department of Genetics [V. N. K., E. K. H., A-L. B-D.] and Department of Oncology [B. E.], Institute of Cancer Research, the Norwegian Radium Hospital, University Clinic, Montebello 0310, Oslo; Department of Biochemistry, University of Oslo, Oslo 0316 [K. B. A., O. S. G.]; Department of Oncology, Haukeland Hospital, 5021 Bergen [P. E. L.]; and Department of Oncology, Ullevål Hospital, Oslo 0407 [R. K.], Norway.

The ability of a motif of the CYP17 5' untranslated region, created by a polymorphic T to C substitution, to bind to the human transcription factor Sp-1 was investigated. No binding of any of the polymorphic alleles was observed in electromobility shift assay. No other sequence within +1 to +100 of each of the CYP17 alleles formed complex with the Sp-1 or enhanced binding to the polymorphic CACC box. Genotyping of 510 breast cancer patients and 201 controls revealed no difference in genotype frequencies. Age at onset, tumor grade, lymph node status and distant metastases, stage, and estrogen and progesterone receptor status were not associated with the CYP17 genotype.




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