| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Advances in Brief |
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 [S-Y. S., P. Y., W. K. H., R. L.]; Laboratory of Molecular Oncology and Cell Cycle Regulation, Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 [G. S. W., W. S. E.]; and Galderma Research and Development, 06905 Sophia Antipolis, France [B. S.]
CD437 is a novel retinoid that can induce apoptosis in a variety of tumor cell types by an unknown mechanism. We found that CD437 up-regulated the expression of p21WAF1/CIP1, Bax, and Killer/DR5 and induced G1 arrest and rapid apoptosis in three human non-small cell lung carcinoma cell lines with wild-type p53 but not in five cell lines with mutant p53, suggesting a role for p53 in the effects of CD437. Using H460 cells in which wild-type p53 protein was degraded by transfection of the human papillomavirus 16 E6 (HPV-16 E6) gene and H460 cells transfected with a control plasmid only, we found that CD437 increased p53, p21WAF1/CIP1, Bax, and Killer/DR5 in the control transfectants. In contrast, the constitutive p53 protein level was suppressed, and the ability of CD437 to increase p53 and its downstream genes was compromised in E6 transfectants. In addition, CD437 induced G1 arrest and apoptosis in the control transfectants but not in the E6-transfected cells. These results indicate that p53 plays a role in CD437-induced growth inhibition and apoptosis in human non-small cell lung carcinoma cells.
This article has been cited by other articles:
|
|
 |
|
  Y.-D. Lin, S. Chen, P. Yue, W. Zou, D. M. Benbrook, S. Liu, T. C. Le, K. D. Berlin, F. R. Khuri, and S.-Y. Sun CAAT/Enhancer Binding Protein Homologous Protein-Dependent Death Receptor 5 Induction Is a Major Component of SHetA2-Induced Apoptosis in Lung Cancer Cells Cancer Res., July 1, 2008; 68(13): 5335 - 5344. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Gillenwater, M. Zhong, and R. Lotan Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells Mol. Cancer Ther., November 1, 2007; 6(11): 2967 - 2975. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hormi-Carver, L. A. Feagins, S. J. Spechler, and R. F. Souza All trans-retinoic acid induces apoptosis via p38 and caspase pathways in metaplastic Barrett's cells Am J Physiol Gastrointest Liver Physiol, January 1, 2007; 292(1): G18 - G27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Parrella, M. Gianni, M. Fratelli, M. M. Barzago, I. Raska Jr, L. Diomede, M. Kurosaki, C. Pisano, P. Carminati, L. Merlini, et al. Antitumor Activity of the Retinoid-Related Molecules (E)-3-(4'-Hydroxy-3'-adamantylbiphenyl-4-yl)acrylic Acid (ST1926) and 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) in F9 Teratocarcinoma: Role of Retinoic Acid Receptor {gamma} and Retinoid-Independent Pathways Mol. Pharmacol., September 1, 2006; 70(3): 909 - 924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mrass, M. Rendl, M. Mildner, F. Gruber, B. Lengauer, C. Ballaun, L. Eckhart, and E. Tschachler Retinoic Acid Increases the Expression of p53 and Proapoptotic Caspases and Sensitizes Keratinocytes to Apoptosis: A Possible Explanation for Tumor Preventive Action of Retinoids Cancer Res., September 15, 2004; 64(18): 6542 - 6548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bayon, M. A. Ortiz, F. J. Lopez-Hernandez, P. H. Howe, and F. J. Piedrafita The Retinoid Antagonist MX781 Induces Clusterin Expression in Prostate Cancer Cells via Heat Shock Factor-1 and Activator Protein-1 Transcription Factors Cancer Res., August 15, 2004; 64(16): 5905 - 5912. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, M. I. Dawson, Y. Ning, L. Polin, R. E. Parchment, T. Corbett, A. N. Mohamed, K.-C. Feng, L. Farhana, A. K. Rishi, et al. Induction of apoptosis in retinoid-refractory acute myelogenous leukemia by a novel AHPN analog Blood, November 15, 2003; 102(10): 3743 - 3752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Newman, M. Sakaue, J. S. Koo, K.-S. Kim, S. J. Baek, T. Eling, and A. M. Jetten Differential Regulation of Nonsteroidal Anti-Inflammatory Drug-Activated Gene in Normal Human Tracheobronchial Epithelial and Lung Carcinoma Cells by Retinoids Mol. Pharmacol., March 1, 2003; 63(3): 557 - 564. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. F. Holmes, D. R. Soprano, and K. J. Soprano Elucidation of Molecular Events Mediating Induction of Apoptosis by Synthetic Retinoids Using a CD437-resistant Ovarian Carcinoma Cell Line J. Biol. Chem., November 15, 2002; 277(47): 45408 - 45419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-H. Pan, W.-J. Chen, S.-Y. Lin-Shiau, C.-T. Ho, and J.-K. Lin Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells Carcinogenesis, October 1, 2002; 23(10): 1677 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Kim, R. Lotan, P. Yue, M. B. Sporn, N. Suh, G. W. Gribble, T. Honda, G. S. Wu, W. K. Hong, and S.-Y. Sun Identification of a Novel Synthetic Triterpenoid, Methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, That Potently Induces Caspase-mediated Apoptosis in Human Lung Cancer Cells Mol. Cancer Ther., January 1, 2002; 1(3): 177 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kumar, D. R. Soprano, and H. K. Parekh Cross-Resistance to the Synthetic Retinoid CD437 in a Paclitaxel-resistant Human Ovarian Carcinoma Cell Line Is Independent of the Overexpression of Retinoic Acid Receptor-{gamma} Cancer Res., October 1, 2001; 61(20): 7552 - 7555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Sun, P. Yue, W. K. Hong, and R. Lotan Augmentation of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by the Synthetic Retinoid 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) through Up-Regulation of TRAIL Receptors in Human Lung Cancer Cells Cancer Res., December 1, 2000; 60(24): 7149 - 7155. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Schneider, M. Offterdinger, H. Huber, and T. W. Grunt Activation of Retinoic Acid Receptor {{alpha}} Is Sufficient for Full Induction of Retinoid Responses in SK-BR-3 and T47D Human Breast Cancer Cells Cancer Res., October 1, 2000; 60(19): 5479 - 5487. [Abstract] [Full Text]
|
|
|
|
|
|
S.-Y. Sun, P. Yue, R. A. S. Chandraratna, Y. Tesfaigzi, W. K. Hong, and R. Lotan Dual Mechanisms of Action of the Retinoid CD437: Nuclear Retinoic Acid Receptor-Mediated Suppression of Squamous Differentiation and Receptor-Independent Induction of Apoptosis in UMSCC22B Human Head and Neck Squamous Cell Carcinoma Cells Mol. Pharmacol., September 1, 2000; 58(3): 508 - 514. [Abstract] [Full Text]
|
|
|
|
|
|
M. McVean, H. Xiao, K.-i. Isobe, and J. C. Pelling Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent apigenin in keratinocytes Carcinogenesis, April 1, 2000; 21(4): 633 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Sun, P. Yue, L. Mao, M. I. Dawson, B. Shroot, W. W. Lamph, R. A. Heyman, R. A. S. Chandraratna, K. Shudo, W. K. Hong, et al. Identification of Receptor-selective Retinoids That Are Potent Inhibitors of the Growth of Human Head and Neck Squamous Cell Carcinoma Cells Clin. Cancer Res., April 1, 2000; 6(4): 1563 - 1573. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
