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Clinical Implication of Expression of Platelet-derived Endothelial Cell Growth Factor (PD-ECGF) in Metastatic Lesions of Uterine Cervical Cancers

Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City 500-8705, Japan

The platelet-derived endothelial cell growth factor (PD-ECGF) level was significantly (P < 0.05) increased in 8 of 40 metastatic lymph node lesions of uterine cervical cancers. The prognosis of the eight patients with high PD-ECGF (>10,000 pg/mg protein) in metastatic lymph node lesions was extremely poor. On the other hand, the 24-month survival rate of the 32 patients with low PD-ECGF (<10,000 pg/mg protein) in metastatic lymph node lesions was 75%. This indicates that PD-ECGF may contribute to the advancement of metastatic lesions, and that the PD-ECGF level in metastatic lesions may be a prognostic indicator.

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