Cancer Research Landon Prizes for Basic and Translational Cancer Research Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 3064-3067, July 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vollmer, C. M.
Right arrow Articles by Economou, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vollmer, C. M., Jr.
Right arrow Articles by Economou, J. S.
[Cancer Research 59, 3064-3067, July 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

{alpha}-Fetoprotein-specific Genetic Immunotherapy for Hepatocellular Carcinoma1

Charles M. Vollmer, Jr., Fritz C. Eilber, Lisa H. Butterfield, Antoni Ribas, Vivian B. Dissette, Andrew Koh, Lara D. Montejo, Maggie C. Lee, Kahlil J. Andrews, William H. McBride, John A. Glaspy and James S. Economou2

Divisions of Surgical Oncology [C. M. V., F. C. E., L. H. B., A. R., V. B. D., A. K., L. D. M., M. C. L., K. J. A., J. S. E.], Experimental Radiation Oncology [W. H. M.], and Hematology-Oncology [J. A. G.], University of California Los Angeles, Los Angeles, California 90095

The majority of human hepatocellular carcinomas overexpress {alpha} -fetoprotein (AFP). Two genetic immunization strategies were used to determine whether AFP could serve as a target for T-cell immune responses. Dendritic cells engineered to express AFP produced potent T-cell responses in mice, as evidenced by the generation of AFP-specific CTLs, cytokine-producing T cells, and protective immunity. AFP plasmid-based immunization generated less potent responses. These novel observations demonstrate that this oncofetal antigen can serve as an effective tumor rejection antigen. This provides a rational, gene therapy-based strategy for this disease, which is responsible for the largest number of cancer-related deaths worldwide.




This article has been cited by other articles:


Home page
 Ann. Surg. Oncol.Home page
M. B. Thomas, J. P. O'Beirne, J. Furuse, A. T. C. Chan, G. Abou-Alfa, and P. Johnson
Systemic Therapy for Hepatocellular Carcinoma: Cytotoxic Chemotherapy, Targeted Therapy and Immunotherapy
Ann. Surg. Oncol., April 1, 2008; 15(4): 1008 - 1014.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
G. J. Mizejewski
Physiology of Alpha-Fetoprotein as a Biomarker for Perinatal Distress: Relevance to Adverse Pregnancy Outcome
Experimental Biology and Medicine, September 1, 2007; 232(8): 993 - 1004.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. H. Butterfield, A. Ribas, V. B. Dissette, Y. Lee, J. Q. Yang, P. De la Rocha, S. D. Duran, J. Hernandez, E. Seja, D. M. Potter, et al.
A Phase I/II Trial Testing Immunization of Hepatocellular Carcinoma Patients with Dendritic Cells Pulsed with Four {alpha}-Fetoprotein Peptides.
Clin. Cancer Res., May 1, 2006; 12(9): 2817 - 2825.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Alisa, A. Ives, A. A. Pathan, C. V. Navarrete, R. Williams, A. Bertoletti, and S. Behboudi
Analysis of CD4+ T-Cell Responses to a Novel {alpha}-Fetoprotein-Derived Epitope in Hepatocellular Carcinoma Patients
Clin. Cancer Res., September 15, 2005; 11(18): 6686 - 6694.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Korangy, L. A. Ormandy, J. S. Bleck, J. Klempnauer, L. Wilkens, M. P. Manns, and T. F. Greten
Spontaneous Tumor-Specific Humoral and Cellular Immune Responses to NY-ESO-1 in Hepatocellular Carcinoma
Clin. Cancer Res., July 1, 2004; 10(13): 4332 - 4341.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Kuang, B. G. Peng, M. D. Lu, L. J. Liang, J. F. Huang, Q. He, Y. P. Hua, S. Totsuka, S. Q. Liu, K. W. Leong, et al.
Phase II Randomized Trial of Autologous Formalin-Fixed Tumor Vaccine for Postsurgical Recurrence of Hepatocellular Carcinoma
Clin. Cancer Res., March 1, 2004; 10(5): 1574 - 1579.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. H. Butterfield, A. Ribas, W. S. Meng, V. B. Dissette, S. Amarnani, H. T. Vu, E. Seja, K. Todd, J. A. Glaspy, W. H. McBride, et al.
T-Cell Responses to HLA-A*0201 Immunodominant Peptides Derived from {alpha}-Fetoprotein in Patients with Hepatocellular Cancer
Clin. Cancer Res., December 1, 2003; 9(16): 5902 - 5908.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
W. S. Meng, L. H. Butterfield, A. Ribas, V. B. Dissette, J. B. Heller, G. A. Miranda, J. A. Glaspy, W. H. McBride, and J. S. Economou
{alpha}-Fetoprotein-specific Tumor Immunity Induced by Plasmid Prime-Adenovirus Boost Genetic Vaccination
Cancer Res., December 1, 2001; 61(24): 8782 - 8786.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Ribas, L. H. Butterfield, S. N. Amarnani, V. B. Dissette, D. Kim, W. S. Meng, G. A. Miranda, H.-J. Wang, W. H. McBride, J. A. Glaspy, et al.
CD40 Cross-Linking Bypasses the Absolute Requirement for CD4 T Cells during Immunization with Melanoma Antigen Gene-modified Dendritic Cells
Cancer Res., December 1, 2001; 61(24): 8787 - 8793.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
G. J. Mizejewski
Alpha-fetoprotein Structure and Function: Relevance to Isoforms, Epitopes, and Conformational Variants
Experimental Biology and Medicine, May 1, 2001; 226(5): 377 - 408.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
L. H. Butterfield, W. S. Meng, A. Koh, C. M. Vollmer, A. Ribas, V. B. Dissette, K. Faull, J. A. Glaspy, W. H. McBride, and J. S. Economou
T Cell Responses to HLA-A*0201-Restricted Peptides Derived from Human {{alpha}} Fetoprotein
J. Immunol., April 15, 2001; 166(8): 5300 - 5308.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Kröger, D. Ortmann, T. U. Krohne, L. Mohr, H. E. Blum, H. Hauser, and M. Geissler
Growth Suppression of the Hepatocellular Carcinoma Cell Line Hepa1-6 by an Activatable Interferon Regulatory Factor-1 in Mice
Cancer Res., March 1, 2001; 61(6): 2609 - 2617.
[Abstract] [Full Text]

Home page
 The OncologistHome page
A. Ribas, L. H. Butterfield, and J. S. Economou
Genetic Immunotherapy for Cancer
Oncologist, April 1, 2000; 5(2): 87 - 98.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.