Cancer Research AACR Conference on Molecular Diagnostics - 2008 Cancer Health Disparities Conference 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 3180-3184, July 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nilsson, G.
Right arrow Articles by Larsson, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nilsson, G.
Right arrow Articles by Larsson, O.
[Cancer Research 59, 3180-3184, July 1, 1999]
© 1999 American Association for Cancer Research

Molecular Biology and Genetics

The SYT-SSX1 Variant of Synovial Sarcoma Is Associated with a High Rate of Tumor Cell Proliferation and Poor Clinical Outcome1

Gunnar Nilsson2, Björn Skytting2, Yuntao Xie2, Bertha Brodin2, Roland Perfekt, Nils Mandahl, Joakim Lundeberg, Mathias Uhlén and Olle Larsson3

Cellular and Molecular Tumor Pathology, CCK, R8: 04 [G. N., Y. X., B. B., O. L.] and Department of Orthopedics [G. N.], Karolinska Hospital, SE-171 76 Stockholm, Sweden; Department of Orthopedics, Stockholm Söder Hospital, SE-100 64 Stockholm, Sweden [B. S.]; Department of Biotechnology, Royal Institute of Technology (KTH), SE-100 44 Stockholm, Sweden [B. B., J. L., M. U.]; and Southern Swedish Regional Tumor Registry [R. P.] and Department of Clinical Genetics [N. M.], University Hospital, SE-221 85 Lund, Sweden

Cytogenetically, synovial sarcoma (SS) is characterized by the translocation t(X;18)(p11.2;q11.2), resulting in a fusion between the SYT gene on chromosome 18 and SSX1 or SSX2 on the X chromosome and the formation of new chimeric genes, SYT-SSX1 or SYT-SSX2. We examined the potential clinical relevance of SYT-SSX1 and SYT-SSX2 fusion transcripts together with tumor proliferation. In a series of 33 patients with primary SS, the type of fusion transcript was assessed by reverse transcription-PCR and sequence analysis. The proliferation rate was analyzed using anti-Ki-67 antibodies. One case carrying an atypical transcript with a 57-bp insert was excluded, leaving 13 SYT-SSX1 and 19 SYT-SSX2 cases for analysis. The hazard ratio (with respect to metastasis-free survival for patients with SYT-SSX1 versus patients with SYT-SSX2 fusion transcripts was 7.4 (95% confidence interval, 1.5–36; log-rank P = 0.004). There was also an association with reduced overall survival for patients with SYT-SSX1 compared to patients with SYT-SSX2 (hazard ratio, 8.5; 95% confidence interval, 1.0–73; log-rank P = 0.02). The 5-year metastasis-free survival for patients with SYT-SSX1 was 42% versus 89% for patients with SYT-SSX2. There was a significant association between SYT-SSX1 and a high tumor proliferation rate (P = 0.02). We conclude that the findings suggest that the type of SYT-SSX fusion transcript determines the proliferation rate and is an important predictor of clinical outcome in patients with SS.




This article has been cited by other articles:


Home page
 J. Clin. Pathol.Home page
O. Slater and J. Shipley
Clinical relevance of molecular genetics to paediatric sarcomas
J. Clin. Pathol., November 1, 2007; 60(11): 1187 - 1194.
[Abstract] [Full Text] [PDF]

Home page
 RadioGraphicsHome page
M. D. Murphey, M. S. Gibson, B. T. Jennings, A. M. Crespo-Rodriguez, J. Fanburg-Smith, and D. A. Gajewski
From the Archives of the AFIP: Imaging of Synovial Sarcoma with Radiologic-Pathologic Correlation
RadioGraphics, September 1, 2006; 26(5): 1543 - 1565.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Xu, L. Yao, T. Ouyang, J. Li, T. Wang, Z. Fan, B. Lin, Y. Lu, and Y. Xie
p53 Codon 72 Polymorphism Predicts the Pathologic Response to Neoadjuvant Chemotherapy in Patients with Breast Cancer
Clin. Cancer Res., October 15, 2005; 11(20): 7328 - 7333.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. Guillou and J.-M. Coindre
In Reply:
J. Clin. Oncol., May 20, 2005; 23(15): 3639 - 3640.
[Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
T. Hosono, M. Hironaka, A. Kobayashi, H. Yamasawa, M. Bando, S. Ohno, Y. Sohara, and Y. Sugiyama
Primary Pulmonary Synovial Sarcoma Confirmed by Molecular Detection of SYT-SSX1 Fusion Gene Transcripts: a Case Report and Review of the Literature
Jpn. J. Clin. Oncol., May 1, 2005; 35(5): 274 - 279.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. M. Oliveira and C. D.M. Fletcher
Molecular Prognostication for Soft Tissue Sarcomas: Are We Ready Yet?
J. Clin. Oncol., October 15, 2004; 22(20): 4031 - 4034.
[Full Text] [PDF]

Home page
 JCOHome page
L. Guillou, J. Benhattar, F. Bonichon, G. Gallagher, P. Terrier, E. Stauffer, N. de Saint Aubain Somerhausen, J.-J. Michels, G. Jundt, D. R. Vince, et al.
Histologic Grade, But Not SYT-SSX Fusion Type, Is an Important Prognostic Factor in Patients With Synovial Sarcoma: A Multicenter, Retrospective Analysis
J. Clin. Oncol., October 15, 2004; 22(20): 4040 - 4050.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
S. Dennison, E. Weppler, and G. Giacoppe
Primary Pulmonary Synovial Sarcoma: A Case Report and Review of Current Diagnostic and Therapeutic Standards
Oncologist, June 1, 2004; 9(3): 339 - 342.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
R. Gaffney, A. Chakerian, J. X. O'Connell, J. Mathers, K. Garner, N. Joste, and D. S. Viswanatha
Novel Fluorescent Ligase Detection Reaction and Flow Cytometric Analysis of SYT-SSX Fusions in Synovial Sarcoma
J. Mol. Diagn., May 1, 2003; 5(2): 127 - 135.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
T. Hosaka, Y. Nakashima, K. Kusuzaki, H. Murata, T. Nakayama, T. Nakamata, T. Aoyama, T. Okamoto, K. Nishijo, N. Araki, et al.
A Novel Type of EWS-CHOP Fusion Gene in Two Cases of Myxoid Liposarcoma
J. Mol. Diagn., August 1, 2002; 4(3): 164 - 171.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
M. J. O'Sullivan, P. A. Humphrey, L. P. Dehner, and J. D. Pfeifer
t(X;18) Reverse Transcriptase-Polymerase Chain Reaction Demonstrating a Variant Transcript
J. Mol. Diagn., August 1, 2002; 4(3): 178 - 180.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Xie, B. Skytting, G. Nilsson, A. Gasbarri, K. Haslam, A. Bartolazzi, B. Brodin, N. Mandahl, and O. Larsson
SYT-SSX Is Critical for Cyclin D1 Expression in Synovial Sarcoma Cells: A Gain of Function of the t(X;18)(p11.2;q11.2) Translocation
Cancer Res., July 1, 2002; 62(13): 3861 - 3867.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
P. H.B. Sorensen, J. C. Lynch, S. J. Qualman, R. Tirabosco, J. F. Lim, H. M. Maurer, J. A. Bridge, W. M. Crist, T. J. Triche, and F. G. Barr
PAX3-FKHR and PAX7-FKHR Gene Fusions Are Prognostic Indicators in Alveolar Rhabdomyosarcoma: A Report From the Children's Oncology Group
J. Clin. Oncol., June 1, 2002; 20(11): 2672 - 2679.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
K. E. Bijwaard, J. F. Fetsch, R. Przygodzki, J. K. Taubenberger, and J. H. Lichy
Detection of SYT-SSX Fusion Transcripts in Archival Synovial Sarcomas by Real-Time Reverse Transcriptase-Polymerase Chain Reaction
J. Mol. Diagn., February 1, 2002; 4(1): 59 - 64.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Ladanyi, C. R. Antonescu, D. H. Leung, J. M. Woodruff, A. Kawai, J. H. Healey, M. F. Brennan, J. A. Bridge, J. R. Neff, F. G. Barr, et al.
Impact of SYT-SSX Fusion Type on the Clinical Behavior of Synovial Sarcoma: A Multi-Institutional Retrospective Study of 243 Patients
Cancer Res., January 1, 2002; 62(1): 135 - 140.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
M. C. Gebhardt
What's New in Musculoskeletal Tumor Surgery
J. Bone Joint Surg. Am., April 1, 2001; 83(4): 629 - 629.
[Full Text]

Home page
 NEJMHome page
T. A. Einhorn and G. P. Nielsen
Case 1-2001- A 26-Year-Old Man with a Mass in the Knee
N. Engl. J. Med., January 11, 2001; 344(2): 124 - 131.
[Full Text] [PDF]

Home page
 INT J SURG PATHOLHome page
J. Rosai
Editorial: Genes and Cancer
International Journal of Surgical Pathology, July 1, 2000; 8(3): 175 - 176.
[PDF]

Home page
 Am. J. Pathol.Home page
M. Ladanyi
Diagnosis and Classification of Small Round-Cell Tumors of Childhood
Am. J. Pathol., December 1, 1999; 155(6): 2181 - 2182.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
Y. Xie, B. Skytting, G. Nilsson, B. Brodin, and O. Larsson
Expression of Insulin-like Growth Factor-1 Receptor in Synovial Sarcoma: Association with an Aggressive Phenotype
Cancer Res., August 1, 1999; 59(15): 3588 - 3591.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.