| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Advances in Brief |
B Signaling1
Department of Bioscience at Novum, Karolinska Institute, NOVUM, S-141 57 Huddinge, Sweden [M. v. H., R. T.]; Department of Clinical Pathology and Cytology, F49, Huddinge University Hospital, S-141 86 Huddinge, Sweden [B. L. R.]; and Department of Medical Nutrition, Huddinge University Hospital, NOVUM, S-141 86 Huddinge, Sweden [L. Ä-R.]
The Rel/nuclear factor-
B (Rel/NF-B) transcription factors have been implicated previously in control of apoptosis, cell proliferation, and oncogenesis. Here we show that selective inhibition of Rel/NF-B signaling in murine skin, by targeted overexpression of a super-repressor form of IB-
, results in an increased basal frequency of apoptotic cells and the spontaneous development of squamous cell carcinomas. Presence of hyperplasia and hair follicle degeneration demonstrate an important role for Rel/NF-B signaling in normal epidermal development and homeostasis. Transgenic skin, in addition, showed an enhanced sensitivity to UV-induced apoptosis. These data suggest an involvement of the Rel/NF-B signaling pathway in apoptosis and cancer development of the skin.
This article has been cited by other articles:
|
|
 |
|
  J. W. Choi, J. Y. Um, J. K. Kundu, Y.-J. Surh, and S. Kim Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis Carcinogenesis, September 1, 2009; 30(9): 1638 - 1644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Tabruyn, S. Memet, P. Ave, C. Verhaeghe, K. H. Mayo, I. Struman, J. A. Martial, and A. W. Griffioen NF-{kappa}B activation in endothelial cells is critical for the activity of angiostatic agents Mol. Cancer Ther., September 1, 2009; 8(9): 2645 - 2654. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Bauer and E. A. Rondini REVIEW PAPER: The Role of Inflammation in Mouse Pulmonary Neoplasia Vet. Pathol., May 1, 2009; 46(3): 369 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Gu, G. T. Bowden, D. Normolle, and Y. Sun SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and I{kappa}B-{alpha}/NF-{kappa}B J. Cell Biol., September 7, 2007; 178(6): 1009 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Van Waes Nuclear Factor-{kappa}B in Development, Prevention, and Therapy of Cancer Clin. Cancer Res., February 15, 2007; 13(4): 1076 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jewett, C. Head, and N.A. Cacalano Emerging Mechanisms of Immunosuppression in Oral Cancers Journal of Dental Research, December 1, 2006; 85(12): 1061 - 1073. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Chen, Y. Lu, V. Castranova, Z. Li, and M. Karin Loss of Ikkbeta Promotes Migration and Proliferation of Mouse Embryo Fibroblast Cells J. Biol. Chem., December 1, 2006; 281(48): 37142 - 37149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. O'Mahony, J. Raber, M. Montano, E. Foehr, V. Han, S.-m. Lu, H. Kwon, A. LeFevour, S. Chakraborty-Sett, and W. C. Greene NF-{kappa}B/Rel Regulates Inhibitory and Excitatory Neuronal Function and Synaptic Plasticity. Mol. Cell. Biol., October 1, 2006; 26(19): 7283 - 7298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Proweller, L. Tu, J. J. Lepore, L. Cheng, M. M. Lu, J. Seykora, S. E. Millar, W. S. Pear, and M. S. Parmacek Impaired Notch Signaling Promotes De novo Squamous Cell Carcinoma Formation. Cancer Res., August 1, 2006; 66(15): 7438 - 7444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ren, C. Kari, M. R.D. Quadros, R. Burd, P. McCue, A. P. Dicker, and U. Rodeck Malignant Transformation of Immortalized HaCaT Keratinocytes through Deregulated Nuclear Factor {kappa}B Signaling. Cancer Res., May 15, 2006; 66(10): 5209 - 5215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.-C. Nguyen, K. Lefort, A. Mandinova, D. Antonini, V. Devgan, G. Della Gatta, M. I. Koster, Z. Zhang, J. Wang, A. T. di Vignano, et al. Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation Genes & Dev., April 15, 2006; 20(8): 1028 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nenci, M. Huth, A. Funteh, M. Schmidt-Supprian, W. Bloch, D. Metzger, P. Chambon, K. Rajewsky, T. Krieg, I. Haase, et al. Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling Hum. Mol. Genet., February 15, 2006; 15(4): 531 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. El-Abaseri, S. Putta, and L. A. Hansen Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor Carcinogenesis, February 1, 2006; 27(2): 225 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Farhana, M. I. Dawson, and J. A. Fontana Apoptosis Induction by a Novel Retinoid-Related Molecule Requires Nuclear Factor-{kappa}B Activation Cancer Res., June 1, 2005; 65(11): 4909 - 4917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Banno, A. Gazel, and M. Blumenberg Pathway-specific Profiling Identifies the NF-{kappa}B-dependent Tumor Necrosis Factor {alpha}-regulated Genes in Epidermal Keratinocytes J. Biol. Chem., May 13, 2005; 280(19): 18973 - 18980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-G. Bladh, J. Liden, A. Pazirandeh, I. Rafter, K. Dahlman-Wright, S. Nilsson, and S. Okret Identification of Target Genes Involved in the Antiproliferative Effect of Glucocorticoids Reveals a Role for Nuclear Factor-{kappa}B Repression Mol. Endocrinol., March 1, 2005; 19(3): 632 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Zhang, S. Tao, R. Kimmel, and P. A. Khavari CDK4 regulation by TNFR1 and JNK is required for NF-{kappa}B-mediated epidermal growth control J. Cell Biol., February 14, 2005; 168(4): 561 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Cataisson, A. J. Pearson, S. Torgerson, S. A. Nedospasov, and S. H. Yuspa Protein Kinase C{alpha}-Mediated Chemotaxis of Neutrophils Requires NF-{kappa}B Activity but Is Independent of TNF{alpha} Signaling in Mouse Skin In Vivo J. Immunol., February 1, 2005; 174(3): 1686 - 1692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Gugasyan, A. Voss, G. Varigos, T. Thomas, R. J. Grumont, P. Kaur, G. Grigoriadis, and S. Gerondakis The Transcription Factors c-rel and RelA Control Epidermal Development and Homeostasis in Embryonic and Adult Skin via Distinct Mechanisms Mol. Cell. Biol., July 1, 2004; 24(13): 5733 - 5745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Lind, B. Rozell, R. P. A. Wallin, M. van Hogerlinden, H.-G. Ljunggren, R. Toftgard, and I. Sur Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-{kappa}B inhibition PNAS, April 6, 2004; 101(14): 4972 - 4977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bernard, K. Gosselin, D. Monte, C. Vercamer, F. Bouali, A. Pourtier, B. Vandenbunder, and C. Abbadie Involvement of Rel/Nuclear Factor-{kappa}B Transcription Factors in Keratinocyte Senescence Cancer Res., January 15, 2004; 64(2): 472 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Zhang, C. L. Green, S. Tao, and P. A. Khavari NF-{kappa}B RelA opposes epidermal proliferation driven by TNFR1 and JNK Genes & Dev., January 1, 2004; 18(1): 17 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Regamey, D. Hohl, J. W. Liu, T. Roger, P. Kogerman, R. Toftgard, and M. Huber The Tumor Suppressor CYLD Interacts with TRIP and Regulates Negatively Nuclear Factor {kappa}B Activation by Tumor Necrosis Factor J. Exp. Med., December 15, 2003; 198(12): 1959 - 1964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Thornburg, R. Pathmanathan, and N. Raab-Traub Activation of Nuclear Factor-{kappa}B p50 Homodimer/Bcl-3 Complexes in Nasopharyngeal Carcinoma Cancer Res., December 1, 2003; 63(23): 8293 - 8301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Santos, P. Perez, C. Segrelles, S. Ruiz, J. L. Jorcano, and J. M. Paramio Impaired NF-kappa B Activation and Increased Production of Tumor Necrosis Factor alpha in Transgenic Mice Expressing Keratin K10 in the Basal Layer of the Epidermis J. Biol. Chem., April 4, 2003; 278(15): 13422 - 13430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Carlsen, J. O. Moskaug, S. H. Fromm, and R. Blomhoff In Vivo Imaging of NF-{kappa}B Activity J. Immunol., February 1, 2002; 168(3): 1441 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Seitz, H. Deng, K. Hinata, Q. Lin, and P. A. Khavari Nuclear Factor {{kappa}}B Subunits Induce Epithelial Cell Growth Arrest Cancer Res., August 1, 2000; 60(15): 4085 - 4092. [Abstract] [Full Text]
|
|
|
|
|
|
S. Huang, A. DeGuzman, C. D. Bucana, and I. J. Fidler Nuclear Factor-{{kappa}}B Activity Correlates with Growth, Angiogenesis, and Metastasis of Human Melanoma Cells in Nude Mice Clin. Cancer Res., June 1, 2000; 6(6): 2573 - 2581. [Abstract] [Full Text]
|
|
|
|
|
|
C. K. Kaufman and E. Fuchs It's Got You Covered: Nf-{kappa}b in the Epidermis J. Cell Biol., May 29, 2000; 149(5): 999 - 1004. [Full Text] [PDF]
|
|
|
|
|
|
H. J. Muenchen, D.-L. Lin, M. A. Walsh, E. T. Keller, and K. J. Pienta Tumor Necrosis Factor-{{alpha}}-induced Apoptosis in Prostate Cancer Cells through Inhibition of Nuclear Factor-{{kappa}}B by an I{{kappa}}B{{alpha}} "Super-Repressor" Clin. Cancer Res., May 1, 2000; 6(5): 1969 - 1977. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Cancer Research | Clinical Cancer Research |
| Cancer Epidemiology Biomarkers & Prevention | Molecular Cancer Therapeutics |
| Molecular Cancer Research | Cancer Prevention Research |
| Cancer Prevention Journals Portal | Cancer Reviews Online |
| Annual Meeting Education Book | Meeting Abstracts Online |
