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[Cancer Research 59, 3299-3303, July 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 3299-3303, July 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Squamous Cell Carcinomas and Increased Apoptosis in Skin with Inhibited Rel/Nuclear Factor-{kappa}B Signaling1

Max van Hogerlinden, Barbro Lundh Rozell, Lars Ährlund-Richter and Rune ToftgÅrd2

Department of Bioscience at Novum, Karolinska Institute, NOVUM, S-141 57 Huddinge, Sweden [M. v. H., R. T.]; Department of Clinical Pathology and Cytology, F49, Huddinge University Hospital, S-141 86 Huddinge, Sweden [B. L. R.]; and Department of Medical Nutrition, Huddinge University Hospital, NOVUM, S-141 86 Huddinge, Sweden [L. Ä-R.]

The Rel/nuclear factor-{kappa}B (Rel/NF-{kappa}B) transcription factors have been implicated previously in control of apoptosis, cell proliferation, and oncogenesis. Here we show that selective inhibition of Rel/NF-{kappa}B signaling in murine skin, by targeted overexpression of a super-repressor form of I{kappa}B-{alpha}, results in an increased basal frequency of apoptotic cells and the spontaneous development of squamous cell carcinomas. Presence of hyperplasia and hair follicle degeneration demonstrate an important role for Rel/NF-{kappa}B signaling in normal epidermal development and homeostasis. Transgenic skin, in addition, showed an enhanced sensitivity to UV-induced apoptosis. These data suggest an involvement of the Rel/NF-{kappa}B signaling pathway in apoptosis and cancer development of the skin.




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HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.