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[Cancer Research 59, 3313-3316, July 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 3313-3316, July 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Association of Matrilysin Expression with Recurrence and Poor Prognosis in Human Esophageal Squamous Cell Carcinoma1

Hiroyuki Yamamoto2, Yasushi Adachi2, Fumio Itoh3, Shouhei Iku, Keiki Matsuno, Masanobu Kusano, Yoshiaki Arimura, Takao Endo, Yuji Hinoda, Masao Hosokawa and Kohzoh Imai

First Department of Internal Medicine, Sapporo Medical University, Sapporo, 060-8543 [H. Y., Y. A., F. I., S. I., K. M., M. K., Y. A., T. E., Y. H., K. I.]; and Surgery, Keiyukai Sapporo Hospital, Sapporo, 030-0027 [M. K., M. H.], Japan

Matrix metalloproteinase-7 (matrilysin) has been implicated in tumor invasion and metastasis as well as tumor initiation and growth. In this study, we analyzed an association between immunohistochemically detected matrilysin expression at the invasive front in esophageal squamous cell carcinomas and clinicopathological characteristics and determined whether matrilysin predicts recurrence and/or survival. Matrilysin expression at the invasive front was detected in 49% of 100 carcinoma tissues and was associated with the depth of invasion (P < 0.0001), advanced tumor stage (P = 0.0159), recurrences (P = 0.0002), and recurrences within the first postoperative year (P = 0.002). Patients with matrilysin-positive carcinoma had a significantly shorter disease-free and overall survival time than did those with a matrilysin-negative one (P < 0.0001). Matrilysin remained a significant predictive value for disease-free and overall survival in multivariate analysis, including conventional clinicopathological factors (P = 0.0007 and 0.0004, respectively). Our results suggest that matrilysin may play a key role in the progression of esophageal carcinoma and that its detection may be useful for the prediction of recurrence and poor prognosis and, possibly, for selecting patients for anti-matrix metalloproteinase therapy.




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Copyright © 1999 by the American Association for Cancer Research.