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[Cancer Research 59, 3329-3332, July 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 3329-3332, July 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Antigen-presenting Cells That Phagocytose Apoptotic Tumor-derived Cells Are Potent Tumor Vaccines1

Frédéric Henry, Olivier Boisteau, Laurent Bretaudeau, Blandine Lieubeau, Khaled Meflah and Marc Grégoire2

Institut National de la Santé et de la Recherche Médicale 419, IFR 26, Biology Institute, 44035 Nantes, France

We have reported recently that treatments combining injections of apoptotic bodies from tumor cells and interleukin 2 led to tumor regression and induced specific protection. In the present study, we show that tumor-bearing rats were cured with an 80% success rate by injection of antigen-presenting cells (APCs) that had phagocytosed apoptotic bodies derived from poorly immunogenic tumor cells, whereas phagocytic cells exposed to nonapoptotic tumor cell extracts were essentially without effect. In addition, curative vaccination using APCs that had phagocytosed apoptotic bodies generated a tumor-specific cytotoxic T-cell response and long-term protection from parental tumor challenge. Thus, systems using the processing and presentation of antigenic molecules by professional APCs after phagocytosis of apoptotic bodies appear to offer new possibilities for anticancer treatment.




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Copyright © 1999 by the American Association for Cancer Research.