Cancer Research Cancer Epigenetics Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 3340-3345, July 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eggert, A. A. O.
Right arrow Articles by Adema, G. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eggert, A. A. O.
Right arrow Articles by Adema, G. J.
[Cancer Research 59, 3340-3345, July 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Biodistribution and Vaccine Efficiency of Murine Dendritic Cells Are Dependent on the Route of Administration1

Andreas A. O. Eggert, Marco W. J. Schreurs, Otto C. Boerman, Wim J. C. Oyen, Annemiek J. de Boer, Cornelis J. A. Punt, Carl G. Figdor and Gosse J. Adema2

Tumor Immunology Laboratory [A. A. O. E., M. W. J. S., A. J. d. B., C. G. F., G. J. A.] and Departments of Nuclear Medicine [O. C. B., W. J. C. O.] and Medical Oncology [C. J. A. P.], University Hospital Nijmegen St. Radboud, 6525 EX Nijmegen, the Netherlands

Dendritic cells (DCs) are professional antigen-presenting cells, well equipped to initiate an immune response. Currently, tumor antigen-derived peptide loaded DCs are used in clinical vaccination in cancer patients. However, the optimal dose and route of administration of a DC vaccine still remain to be determined. Using indium-111-labeled DCs, we investigated whether the route of administration does affect the biodistribution of DCs in lymphoid organs and whether it influences the outcome of DC vaccination in the B16 mouse melanoma tumor model. The results demonstrate that i.v. injected DCs mainly accumulate in the spleen, whereas s.c. injected DCs preferentially home to the T-cell areas of the draining lymph nodes. Using tyrosinase-related protein-2-derived peptide-loaded DC vaccination in a fully autologous B16 melanoma tumor model, we observed a delay in tumor growth, improved survival as well as increased antitumor cytotoxic T-cell reactivity after s.c. vaccination as compared to i.v. vaccination. These data demonstrate that optimal induction of antitumor reactivity against the autologous melanocyte differentiation antigen tyrosinase-related protein-2-derived peptitde occurs after s.c. vaccination and correlates with the preferential accumulation of DCs in the T-cell areas of lymph nodes.




This article has been cited by other articles:


Home page
 BloodHome page
R. J. Creusot, S. S. Yaghoubi, P. Chang, J. Chia, C. H. Contag, S. S. Gambhir, and C. G. Fathman
Lymphoid tissue-specific homing of bone marrow-derived dendritic cells
Blood, June 25, 2009; 113(26): 6638 - 6647.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
P. Verdijk, E. H.J.G. Aarntzen, W. J. Lesterhuis, A.C. I. Boullart, E. Kok, M. M. van Rossum, S. Strijk, F. Eijckeler, J. J. Bonenkamp, J. F.M. Jacobs, et al.
Limited Amounts of Dendritic Cells Migrate into the T-Cell Area of Lymph Nodes but Have High Immune Activating Potential in Melanoma Patients
Clin. Cancer Res., April 1, 2009; 15(7): 2531 - 2540.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Wang, Q. Jiang, C. Chan, K. S. Gorski, E. McCadden, D. Kardian, D. Pardoll, and K. A. Whartenby
Inhibition of activation-induced death of dendritic cells and enhancement of vaccine efficacy via blockade of MINOR
Blood, March 26, 2009; 113(13): 2906 - 2913.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. Fontana, M. Bregni, A. Cipponi, L. Raccosta, C. Rainelli, D. Maggioni, F. Lunghi, F. Ciceri, S. Mukenge, C. Doglioni, et al.
Peripheral blood lymphocytes genetically modified to express the self/tumor antigen MAGE-A3 induce antitumor immune responses in cancer patients
Blood, February 19, 2009; 113(8): 1651 - 1660.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. C. Brinkman, S. L. Sheasley-O'Neill, A. R. Ferguson, and V. H. Engelhard
Activated CD8 T Cells Redistribute to Antigen-Free Lymph Nodes and Exhibit Effector and Memory Characteristics
J. Immunol., August 1, 2008; 181(3): 1814 - 1824.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. L. Sheasley-O'Neill, C. C. Brinkman, A. R. Ferguson, M. C. Dispenza, and V. H. Engelhard
Dendritic Cell Immunization Route Determines Integrin Expression and Lymphoid and Nonlymphoid Tissue Distribution of CD8 T Cells
J. Immunol., February 1, 2007; 178(3): 1512 - 1522.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Liu, B. A. Foster, T. Chen, G. Zheng, and A. Chen
Modifying Dendritic Cells via Protein Transfer for Antitumor Therapeutics
Clin. Cancer Res., January 1, 2007; 13(1): 283 - 291.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Gorantla, H. Dou, M. Boska, C. J. Destache, J. Nelson, L. Poluektova, B. E. Rabinow, H. E. Gendelman, and R. L. Mosley
Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery
J. Leukoc. Biol., November 1, 2006; 80(5): 1165 - 1174.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H.-R. Jiang, D. E. Gilham, K. Mulryan, N. Kirillova, R. E. Hawkins, and P. L. Stern
Combination of Vaccination and Chimeric Receptor Expressing T Cells Provides Improved Active Therapy of Tumors
J. Immunol., October 1, 2006; 177(7): 4288 - 4298.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
S Nagaraj, C Ziske, J Strehl, D Messmer, T Sauerbruch, and I. Schmidt-Wolf
Dendritic cells pulsed with alpha-galactosylceramide induce anti-tumor immunity against pancreatic cancer in vivo
Int. Immunol., August 1, 2006; 18(8): 1279 - 1283.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Kovar, O. Boyman, X. Shen, I. Hwang, R. Kohler, and J. Sprent
Direct stimulation of T cells by membrane vesicles from antigen-presenting cells
PNAS, August 1, 2006; 103(31): 11671 - 11676.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. W. Mullins and V. H. Engelhard
Limited infiltration of exogenous dendritic cells and naive T cells restricts immune responses in peripheral lymph nodes.
J. Immunol., April 15, 2006; 176(8): 4535 - 4542.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. L. M. Vissers, B. C. A. M. van Esch, G. A. Hofman, and A. J. M. van Oosterhout
Macrophages induce an allergen-specific and long-term suppression in a mouse asthma model
Eur. Respir. J., December 1, 2005; 26(6): 1040 - 1046.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
R. van der Voort, M. Kramer, E. Lindhout, R. Torensma, D. Eleveld, A. W. T. van Lieshout, M. Looman, T. Ruers, T. R. D. J. Radstake, C. G. Figdor, et al.
Novel monoclonal antibodies detect elevated levels of the chemokine CCL18/DC-CK1 in serum and body fluids in pathological conditions
J. Leukoc. Biol., May 1, 2005; 77(5): 739 - 747.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
D. Dieckmann, E. S. Schultz, B. Ring, P. Chames, G. Held, H. R. Hoogenboom, and G. Schuler
Optimizing the exogenous antigen loading of monocyte-derived dendritic cells
Int. Immunol., May 1, 2005; 17(5): 621 - 635.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Junt, E. Scandella, R. Forster, P. Krebs, S. Krautwald, M. Lipp, H. Hengartner, and B. Ludewig
Impact of CCR7 on Priming and Distribution of Antiviral Effector and Memory CTL
J. Immunol., December 1, 2004; 173(11): 6684 - 6693.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-J. Chang, K.-F. Tai, S. Roffler, and L.-H. Hwang
The Immunization Site of Cytokine-Secreting Tumor Cell Vaccines Influences the Trafficking of Tumor-Specific T Lymphocytes and Antitumor Efficacy against Regional Tumors
J. Immunol., November 15, 2004; 173(10): 6025 - 6032.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
U. A. Duffner, Y. Maeda, K. R. Cooke, P. Reddy, R. Ordemann, C. Liu, J. L. M. Ferrara, and T. Teshima
Host Dendritic Cells Alone Are Sufficient to Initiate Acute Graft-versus-Host Disease
J. Immunol., June 15, 2004; 172(12): 7393 - 7398.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
W. Brenner, A. Aicher, T. Eckey, S. Massoudi, M. Zuhayra, U. Koehl, C. Heeschen, W. U. Kampen, A. M. Zeiher, S. Dimmeler, et al.
111In-Labeled CD34+ Hematopoietic Progenitor Cells in a Rat Myocardial Infarction Model
J. Nucl. Med., March 1, 2004; 45(3): 512 - 518.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
H. Matsuyoshi, S. Senju, S. Hirata, Y. Yoshitake, Y. Uemura, and Y. Nishimura
Enhanced Priming of Antigen-Specific CTLs In Vivo by Embryonic Stem Cell-Derived Dendritic Cells Expressing Chemokine Along with Antigenic Protein: Application to Antitumor Vaccination
J. Immunol., January 15, 2004; 172(2): 776 - 786.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. A. O'Mara and P. M. Allen
Pulmonary Tumors Inefficiently Prime Tumor-Specific T Cells
J. Immunol., January 1, 2004; 172(1): 310 - 317.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Brandt, S. Bulfone-Paus, D. C. Foster, and R. Ruckert
Interleukin-21 inhibits dendritic cell activation and maturation
Blood, December 1, 2003; 102(12): 4090 - 4098.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
I. J. M. de Vries, W. J. Lesterhuis, N. M. Scharenborg, L. P. H. Engelen, D. J. Ruiter, M.-J. P. Gerritsen, S. Croockewit, C. M. Britten, R. Torensma, G. J. Adema, et al.
Maturation of Dendritic Cells Is a Prerequisite for Inducing Immune Responses in Advanced Melanoma Patients
Clin. Cancer Res., November 1, 2003; 9(14): 5091 - 5100.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
D. W. Mullins, S. L. Sheasley, R. M. Ream, T. N.J. Bullock, Y.-X. Fu, and V. H. Engelhard
Route of Immunization with Peptide-pulsed Dendritic Cells Controls the Distribution of Memory and Effector T Cells in Lymphoid Tissues and Determines the Pattern of Regional Tumor Control
J. Exp. Med., October 6, 2003; 198(7): 1023 - 1034.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
M. L. Thakur, R. Coss, R. Howell, D. Vassileva-Belnikolovska, J. Liu, S. P. Rao, G. Spana, P. Wachsberger, and D. L. Leeper
Role of Lipid-Soluble Complexes in Targeted Tumor Therapy
J. Nucl. Med., August 1, 2003; 44(8): 1293 - 1300.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. Sato, K. Chamoto, and T. Nishimura
A novel tumor-vaccine cell therapy using bone marrow-derived dendritic cell type 1 and antigen-specific Th1 cells
Int. Immunol., July 1, 2003; 15(7): 837 - 843.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Aicher, W. Brenner, M. Zuhayra, C. Badorff, S. Massoudi, B. Assmus, T. Eckey, E. Henze, A. M. Zeiher, and S. Dimmeler
Assessment of the Tissue Distribution of Transplanted Human Endothelial Progenitor Cells by Radioactive Labeling
Circulation, April 29, 2003; 107(16): 2134 - 2139.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. J. Kobie, R. S. Wu, R. A. Kurt, S. Lou, M. K. Adelman, L. J. Whitesell, L. V. Ramanathapuram, C. L. Arteaga, and E. T. Akporiaye
Transforming Growth Factor {beta} Inhibits the Antigen-Presenting Functions and Antitumor Activity of Dendritic Cell Vaccines
Cancer Res., April 15, 2003; 63(8): 1860 - 1864.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. Hou, Y. Wu, S. Sun, M. Shi, Y. Sun, C. Yang, G. Pei, Y. Gu, C. Zhong, and B. Sun
Pertussis Toxin Enhances Th1 Responses by Stimulation of Dendritic Cells
J. Immunol., February 15, 2003; 170(4): 1728 - 1736.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. J. M. de Vries, D. J. E. B. Krooshoop, N. M. Scharenborg, W. J. Lesterhuis, J. H. S. Diepstra, G. N. P. van Muijen, S. P. Strijk, T. J. Ruers, O. C. Boerman, W. J. G. Oyen, et al.
Effective Migration of Antigen-pulsed Dendritic Cells to Lymph Nodes in Melanoma Patients Is Determined by Their Maturation State
Cancer Res., January 1, 2003; 63(1): 12 - 17.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
G. Parmiani, C. Castelli, P. Dalerba, R. Mortarini, L. Rivoltini, F. M. Marincola, and A. Anichini
Cancer Immunotherapy With Peptide-Based Vaccines: What Have We Achieved? Where Are We Going?
J Natl Cancer Inst, June 5, 2002; 94(11): 805 - 818.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Ratzinger, P. Stoitzner, S. Ebner, M. B. Lutz, G. T. Layton, C. Rainer, R. M. Senior, J. M. Shipley, P. Fritsch, G. Schuler, et al.
Matrix Metalloproteinases 9 and 2 Are Necessary for the Migration of Langerhans Cells and Dermal Dendritic Cells from Human and Murine Skin
J. Immunol., May 1, 2002; 168(9): 4361 - 4371.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Bacci, C. Montagnoli, K. Perruccio, S. Bozza, R. Gaziano, L. Pitzurra, A. Velardi, C. F. d'Ostiani, J. E. Cutler, and L. Romani
Dendritic Cells Pulsed with Fungal RNA Induce Protective Immunity to Candida albicans in Hematopoietic Transplantation
J. Immunol., March 15, 2002; 168(6): 2904 - 2913.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. J. Kirk, D. Hartigan-O'Connor, and J. J. Mule
The Dynamics of the T-Cell Antitumor Response: Chemokine-secreting Dendritic Cells Can Prime Tumor-reactive T Cells Extranodally
Cancer Res., December 1, 2001; 61(24): 8794 - 8802.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Fong, D. Brockstedt, C. Benike, L. Wu, and E. G. Engleman
Dendritic Cells Injected Via Different Routes Induce Immunity in Cancer Patients
J. Immunol., March 15, 2001; 166(6): 4254 - 4259.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. J. Kirk, D. Hartigan-O’Connor, B. J. Nickoloff, J. S. Chamberlain, M. Giedlin, L. Aukerman, and J. J. Mulé
T Cell-dependent Antitumor Immunity Mediated by Secondary Lymphoid Tissue Chemokine: Augmentation of Dendritic Cell-based Immunotherapy
Cancer Res., March 1, 2001; 61(5): 2062 - 2070.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
J. S. Serody, E. J. Collins2, R. M. Tisch, J. J. Kuhns, and J. A. Frelinger
T Cell Activity After Dendritic Cell Vaccination Is Dependent on Both the Type of Antigen and the Mode of Delivery
J. Immunol., May 1, 2000; 164(9): 4961 - 4967.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.