Cancer Research Cancer Epigenetics Jordan
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 3512-3517, July 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, Z.-T.
Right arrow Articles by Wu, X.-R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, Z.-T.
Right arrow Articles by Wu, X.-R.
[Cancer Research 59, 3512-3517, July 15, 1999]
© 1999 American Association for Cancer Research

Tumor Biology

Urothelium-specific Expression of an Oncogene in Transgenic Mice Induced the Formation of Carcinoma in Situ and Invasive Transitional Cell Carcinoma1

Zhong-Ting Zhang, Joanne Pak, Ellen Shapiro, Tung-Tien Sun and Xue-Ru Wu2

Departments of Urology [Z-T. Z., E. S., T-T. S., X-R. W.], Microbiology [X-R. W.], Dermatology [T-T. S.], and Pharmacology [T-T. S.], Kaplan Comprehensive Cancer Center, New York University School of Medicine, New York, New York 10016, and Department of Veterans Affairs Medical Center, Manhattan, New York, New York 10010 [J. P., X-R. W.]

Although many genetic alterations are known to be associated with human transitional cell carcinoma (TCC) of the urinary bladder, relatively little is known about the roles of these molecular defects, singular or in combination, in bladder tumorigenesis. We have developed a transgenic mouse model of bladder tumorigenesis using a 3.6-kb promoter of uroplakin II gene to drive the urothelium-specific expression of oncogenes. In this study, we demonstrate that transgenic mice bearing a low copy number of SV40T transgene developed bladder carcinoma in situ (CIS), whereas those bearing high copies developed CIS as well as invasive and metastatic TCCs. These results indicate that the SV40T inactivation of p53 and retinoblastoma gene products, defects frequently found in human bladder CIS and invasive TCCs, can cause the aggressive form of TCC. Our results also provide experimental proof that CIS is a precursor of invasive TCCs, thus supporting the concept of two distinct pathways of bladder tumorigenesis (papillary versus CIS/invasive TCC). This transgenic system can be used for the systematic dissection of the roles of individual or combinations of specific molecular events in bladder tumorigenesis.




This article has been cited by other articles:


Home page
 Genes Dev.Home page
A. M. Puzio-Kuter, M. Castillo-Martin, C. W. Kinkade, X. Wang, T. H. Shen, T. Matos, M. M. Shen, C. Cordon-Cardo, and C. Abate-Shen
Inactivation of p53 and Pten promotes invasive bladder cancer
Genes & Dev., March 15, 2009; 23(6): 675 - 680.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. A. Hadaschik, H. Adomat, L. Fazli, Y. Fradet, R. J. Andersen, M. E. Gleave, and A. I. So
Intravesical Chemotherapy of High-Grade Bladder Cancer with HTI-286, A Synthetic Analogue of the Marine Sponge Product Hemiasterlin
Clin. Cancer Res., March 1, 2008; 14(5): 1510 - 1518.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. A. Karam, S. F. Shariat, H.-Y. Huang, R.-C. Pong, R. Ashfaq, E. Shapiro, Y. Lotan, A. I. Sagalowsky, X.-R. Wu, and J.-T. Hsieh
Decreased DOC-2/DAB2 Expression in Urothelial Carcinoma of the Bladder
Clin. Cancer Res., August 1, 2007; 13(15): 4400 - 4406.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. Liu, D. P. Evanoff, X. Chen, and Y. Luo
Urinary Bladder Epithelium Antigen Induces CD8+ T Cell Tolerance, Activation, and Autoimmune Response
J. Immunol., January 1, 2007; 178(1): 539 - 546.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. Shrader, M. S. Pino, G. Brown, P. Black, L. Adam, M. Bar-Eli, C. P.N. Dinney, and D. J. McConkey
Molecular correlates of gefitinib responsiveness in human bladder cancer cells
Mol. Cancer Ther., January 1, 2007; 6(1): 277 - 285.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Tsuruta, H. Kishimoto, T. Sasaki, Y. Horie, M. Natsui, Y. Shibata, K. Hamada, N. Yajima, K. Kawahara, M. Sasaki, et al.
Hyperplasia and Carcinomas in Pten-Deficient Mice and Reduced PTEN Protein in Human Bladder Cancer Patients.
Cancer Res., September 1, 2006; 66(17): 8389 - 8396.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
R.A. Crallan, N.T. Georgopoulos, and J. Southgate
Experimental models of human bladder carcinogenesis
Carcinogenesis, March 1, 2006; 27(3): 374 - 381.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
F.-X. Liang, M. C. Bosland, H. Huang, R. Romih, S. Baptiste, F.-M. Deng, X.-R. Wu, E. Shapiro, and T.-T. Sun
Cellular basis of urothelial squamous metaplasia: roles of lineage heterogeneity and cell replacement
J. Cell Biol., December 5, 2005; 171(5): 835 - 844.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. Mo, J. Cheng, E. Y.-H. P. Lee, T.-T. Sun, and X.-R. Wu
Gene deletion in urothelium by specific expression of Cre recombinase
Am J Physiol Renal Physiol, September 1, 2005; 289(3): F562 - F568.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Garcia-Espana, E. Salazar, T.-T. Sun, X.-R. Wu, and A. Pellicer
Differential Expression of Cell Cycle Regulators in Phenotypic Variants of Transgenically Induced Bladder Tumors: Implications for Tumor Behavior
Cancer Res., February 15, 2005; 65(4): 1150 - 1157.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Dyrskjot, M. Kruhoffer, T. Thykjaer, N. Marcussen, J. L. Jensen, K. Moller, and T. F. Orntoft
Gene Expression in the Urinary Bladder: A Common Carcinoma in Situ Gene Expression Signature Exists Disregarding Histopathological Classification
Cancer Res., June 1, 2004; 64(11): 4040 - 4048.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Cheng, H. Huang, J. Pak, E. Shapiro, T.-T. Sun, C. Cordon-Cardo, F. M. Waldman, and X.-R. Wu
Allelic Loss of p53 Gene Is Associated with Genesis and Maintenance, but not Invasion, of Mouse Carcinoma in Situ of the Bladder
Cancer Res., January 1, 2003; 63(1): 179 - 185.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Cheng, H. Huang, Z.-T. Zhang, E. Shapiro, A. Pellicer, T.-T. Sun, and X.-R. Wu
Overexpression of Epidermal Growth Factor Receptor in Urothelium Elicits Urothelial Hyperplasia and Promotes Bladder Tumor Growth
Cancer Res., July 15, 2002; 62(14): 4157 - 4163.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. J. Grippo and E. P. Sandgren
Highly Invasive Transitional Cell Carcinoma of the Bladder in a Simian Virus 40 T-Antigen Transgenic Mouse Model
Am. J. Pathol., September 1, 2000; 157(3): 805 - 813.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. R. Saam and J. I. Gordon
Inducible Gene Knockouts in the Small Intestinal and Colonic Epithelium
J. Biol. Chem., December 31, 1999; 274(53): 38071 - 38082.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.