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[Cancer Research 59, 3557-3560, August 1, 1999]
© 1999 American Association for Cancer Research
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[Cancer Research 59, 3557-3560, August 1, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Hormonal Treatment after Cytotoxic Therapy Stimulates Recovery of Spermatogenesis1

Marvin L. Meistrich2, Gene Wilson and Ilpo Huhtaniemi

Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 [M. L. M., G. W.], and Department of Physiology, University of Turku, 20520 Turku, Finland [I. H.]

Previous studies have shown that treatment of rats with gonadotropin-releasing hormone (GnRH) analogues or steroids either before exposure to procarbazine or radiation or after irradiation enhances subsequent levels of spermatogenesis. We demonstrate here that giving a GnRH agonist after procarbazine injection also enhances spermatogenesis and fertility. We also demonstrate that GnRH agonist stimulated recovery of spermatogenesis and fertility not only when the hormone was administered immediately after irradiation, but also at 20 weeks after irradiation, after the decline in spermatogenesis had occurred. These results suggest that GnRH agonist treatment given to azoospermic men after cytotoxic therapy for cancer may stimulate the recovery of spermatogenesis and fertility.




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Copyright © 1999 by the American Association for Cancer Research.