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Bdp, a New Member of a Family of DNA-binding Proteins, Associates with the Retinoblastoma Gene Product¹

Kimmel Cancer Institute [S-i. N., C. M. C.], and Department of Pathology, Anatomy and Cell Biology [P. P. C., C. D., A. G.], Thomas Jefferson University, Philadelphia, Pennsylvania 19107, and Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciali, University of Naples ‘Federico II,’ Naples, Italy [P. P. C.]

We have cloned a gene, BDP, encoding a protein with homology to the retinoblastoma-binding proteins Rbp1 and Rbp2. It also has homology to DNA-binding proteins such as Bright, a B-cell-specific trans-activator, and the Drosophila melanogaster dead ringer gene product. Like MyoD, Bdp binds to the COOH-terminal region of pRb through its conserved region and to hypophosphorylated pRb. It also binds to the MAR of the immunoglobulin heavy-chain locus. Thus Bdp may contribute to the transcriptional regulation of genes involved in differentiation and tissue-specific expression.

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