Cancer Research CTRC-AACR San Antonio Breast Cancer Symposium Tumor Immunology: New Perspectives
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 3880-3882, August 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Koesters, R.
Right arrow Articles by Doeberitz, M. v. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Koesters, R.
Right arrow Articles by Doeberitz, M. v. K.
[Cancer Research 59, 3880-3882, August 15, 1999]
© 1999 American Association for Cancer Research

Advances in Brief

Mutational Activation of the ß-Catenin Proto-Oncogene Is a Common Event in the Development of Wilms’ Tumors1

Robert Koesters2, Ruediger Ridder, Annette Kopp-Schneider, David Betts, Volker Adams, Felix Niggli, Jakob Briner and Magnus von Knebel Doeberitz

Department of Surgery, University of Heidelberg, 69120 Heidelberg, Germany [R. K., R. R., M. v. K. D.]; Central Division of Biostatistics, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany [A. K-S.]; Children’s Hospital of Zurich, 8032 Zurich, Switzerland [D. B., F. N.]; Heart Center, University of Leipzig, 04289 Leipzig, Germany [V. A.]; and Institute of Histological and Cytological Diagnostics, 5001 Aarau, Switzerland [J. B.]

Activation of ß-catenin-mediated transcription is the nuclear end point of organ-specific Wnt signaling. In the developing kidney, Wnt-4, a secreted glycoprotein, acts as an autoinducer of the mesenchymal to epithelial transition that underlies normal nephron development. Dysregulation of this epithelial transformation process may lead to Wilms’ tumors (WTs). In this study, we investigated the potential role of the ß-catenin proto-oncogene, a candidate downstream target molecule of Wnt-4 signaling, in the development of WTs. In 6 of 40 tumors (15%), mutation analysis revealed heterozygous missense mutations or small deletions that result in the loss of important regulatory phosphorylation sites within the ß-catenin protein. These findings indicate that activating ß-catenin mutations may play a significant role in the development of WTs and establish a direct link between Wilms’ tumorigenesis and the Wnt signal transduction pathway governing normal kidney development.




This article has been cited by other articles:


Home page
 haematolHome page
C. Owen, P. Virappane, M. Alikian, I. Stasevich, K. Summers, D. Lillington, D. Bonnet, A. Burnett, K. Mills, T. A. Lister, et al.
WTX is rarely mutated in acute myeloid leukemia
Haematologica, June 1, 2008; 93(6): 947 - 948.
[Full Text] [PDF]

Home page
 J. Med. Genet.Home page
C. Uschkereit, N. Perez, C. de Torres, M. Kuff, J. Mora, and B. Royer-Pokora
Different CTNNB1 mutations as molecular genetic proof for the independent origin of four Wilms tumours in a patient with a novel germ line WT1 mutation
J. Med. Genet., June 1, 2007; 44(6): 393 - 396.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. B. Major, N. D. Camp, J. D. Berndt, X. Yi, S. J. Goldenberg, C. Hubbert, T. L. Biechele, A.-C. Gingras, N. Zheng, M. J. MacCoss, et al.
Wilms Tumor Suppressor WTX Negatively Regulates WNT/{beta}-Catenin Signaling
Science, May 18, 2007; 316(5827): 1043 - 1046.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C.-N. Qian, J. Knol, P. Igarashi, F. Lin, U. Zylstra, B. T. Teh, and B. O. Williams
Cystic Renal Neoplasia Following Conditional Inactivation of Apc in Mouse Renal Tubular Epithelium
J. Biol. Chem., February 4, 2005; 280(5): 3938 - 3945.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
A Ramburan, F Oladiran, C Smith, G P Hadley, and D Govender
Microsatellite analysis of the adenomatous polyposis coli (APC) gene and immunoexpression of {beta} catenin in nephroblastoma: a study including 83 cases treated with preoperative chemotherapy
J. Clin. Pathol., January 1, 2005; 58(1): 44 - 50.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
C.-M. Li, C. E. Kim, A. A. Margolin, M. Guo, J. Zhu, J. M. Mason, T. W. Hensle, V. V.V.S. Murty, P. E. Grundy, E. R. Fearon, et al.
CTNNB1 Mutations and Overexpression of Wnt/{beta}-Catenin Target Genes in WT1-Mutant Wilms' Tumors
Am. J. Pathol., December 1, 2004; 165(6): 1943 - 1953.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Prindull and D. Zipori
Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm
Blood, April 15, 2004; 103(8): 2892 - 2899.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pathol.Home page
J Alami, B R Williams, and H Yeger
Differential expression of E-cadherin and {beta} catenin in primary and metastatic Wilms's tumours
Mol. Pathol., August 1, 2003; 56(4): 218 - 225.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
S. D. Safford, D. Goyeau, A. J. Freemerman, R. Bentley, M. L. Everett, P. E. Grundy, and M. A. Skinner
Fine Mapping of Wilms' Tumors With 16q Loss of Heterozygosity Localizes the Putative Tumor Suppressor Gene to a Region of 6.7 Megabases
Ann. Surg. Oncol., March 1, 2003; 10(2): 136 - 143.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
R. Koesters, M. A. Hans, A. Benner, R. Prosst, J. Boehm, J. Gahlen, and M. von Knebel Doeberitz
Predominant mutation of codon 41 of the {beta}-catenin proto-oncogene in rat colon tumors induced by 1,2-dimethylhydrazine using a complete carcinogenic protocol
Carcinogenesis, November 1, 2001; 22(11): 1885 - 1890.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. C. Abraham, T.-T. Wu, D. S. Klimstra, L. S. Finn, J.-H. Lee, C. J. Yeo, J. L. Cameron, and R. H. Hruban
Distinctive Molecular Genetic Alterations in Sporadic and Familial Adenomatous Polyposis-Associated Pancreatoblastomas : Frequent Alterations in the APC/{beta}-Catenin Pathway and Chromosome 11p
Am. J. Pathol., November 1, 2001; 159(5): 1619 - 1627.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
E. Sadot, B. Geiger, M. Oren, and A. Ben-Ze'ev
Down-Regulation of {beta}-Catenin by Activated p53
Mol. Cell. Biol., October 15, 2001; 21(20): 6768 - 6781.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
W. Szeto, W. Jiang, D. A. Tice, B. Rubinfeld, P. G. Hollingshead, S. E. Fong, D. L. Dugger, T. Pham, D. G. Yansura, T. A. Wong, et al.
Overexpression of the Retinoic Acid-responsive Gene Stra6 in Human Cancers and Its Synergistic Induction by Wnt-1 and Retinoic Acid
Cancer Res., May 1, 2001; 61(10): 4197 - 4205.
[Abstract] [Full Text]

Home page
 Clin. Cancer Res.Home page
H. Takayasu, H. Horie, E. Hiyama, T. Matsunaga, Y. Hayashi, Y. Watanabe, S. Suita, M. Kaneko, F. Sasaki, K. Hashizume, et al.
Frequent Deletions and Mutations of the {beta}-Catenin Gene Are Associated with Overexpression of Cyclin D1 and Fibronectin and Poorly Differentiated Histology in Childhood Hepatoblastoma
Clin. Cancer Res., April 1, 2001; 7(4): 901 - 908.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
G. Garcia-Rostan, R. L. Camp, A. Herrero, M. L. Carcangiu, D. L. Rimm, and G. Tallini
{beta}-Catenin Dysregulation in Thyroid Neoplasms : Down-Regulation, Aberrant Nuclear Expression, and CTNNB1 Exon 3 Mutations Are Markers for Aggressive Tumor Phenotypes and Poor Prognosis
Am. J. Pathol., March 1, 2001; 158(3): 987 - 996.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. C. Abraham, E. A. Montgomery, F. M. Giardiello, and T.-T. Wu
Frequent {beta}-Catenin Mutations in Juvenile Nasopharyngeal Angiofibromas
Am. J. Pathol., March 1, 2001; 158(3): 1073 - 1078.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Maiti, R. Alam, C. I. Amos, and V. Huff
Frequent Association of {beta}-Catenin and WT1 Mutations in Wilms Tumors
Cancer Res., November 1, 2000; 60(22): 6288 - 6292.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
P. Polakis
Wnt signaling and cancer
Genes & Dev., August 1, 2000; 14(15): 1837 - 1851.
[Full Text]

Home page
 J. Biol. Chem.Home page
S. Hosono, I. Gross, M. A. English, K. M. Hajra, E. R. Fearon, and J. D. Licht
E-cadherin Is a WT1 Target Gene
J. Biol. Chem., April 6, 2000; 275(15): 10943 - 10953.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.