Cancer Research Donn Young Sign up for Cancer Research eTOC's
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
[Cancer Research 59, 4056-4063, August 1, 1999]
© 1999 American Association for Cancer Research
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yang, D.
Right arrow Articles by Itoh, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, D.
Right arrow Articles by Itoh, K.
[Cancer Research 59, 4056-4063, August 15, 1999]
© 1999 American Association for Cancer Research

Immunology

Identification of a Gene Coding for a Protein Possessing Shared Tumor Epitopes Capable of Inducing HLA-A24-restricted Cytotoxic T Lymphocytes inCancer Patients1

Damu Yang, Masanobu Nakao, Shigeki Shichijo, Teruo Sasatomi, Hideo Takasu, Hajime Matsumoto, Kazunori Mori, Akihiro Hayashi, Hideaki Yamana, Kazuo Shirouzu and Kyogo Itoh2

Cancer Vaccine Development Division, Kurume University Research Center for Innovative Cancer Therapy [D. Y., M. N., K. I.], and Departments of Surgery [A. H., H. Y., K. S.], Immunology [S. S., T. S., H. T., H. M., K. I.], and Otolaryngology [K. M.], Kurume University School of Medicine, Kurume, 830-0011, Japan

Genes encoding tumor epitopes that are capable of inducing CTLs against adenocarcinomas and squamous cell carcinomas, two major human cancers histologically observed in various organs, have rarely been identified. Here, we report a new gene from cDNA of esophageal cancer cells that encodes a shared tumor antigen recognized by HLA-A2402-restricted and tumor-specific CTLs. The sequence of this gene is almost identical to that of the KIAA0156 gene, which has been registered in GenBank with an unknown function. This gene encodes a Mr 140,000 protein that is expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas, adenocarcinomas, melanomas, and leukemia cells. However, this protein was undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Furthermore, this protein was expressed in the cytosol of all of the proliferating cells, including normal cells and malignant cells, but not in normal tissues, except for the testis and fetal liver. Two peptides of this protein were recognized by HLA-A2402-restricted CTLs and were able to induce HLA-A24-restricted and tumor-specific CTLs from peripheral blood mononuclear cells of most of HLA-A24+ cancer patients tested, but not from peripheral blood mononuclear cells of any healthy donors. These peptides may be useful in specific immunotherapy for HLA-A24+ cancer patients with various histological types.




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
T. Ono, M. Harada, A. Yamada, M. Tanaka, Y. Takao, Y. Tanaka, T. Mine, K. Sakamoto, T. Nakashima, and K. Itoh
Antitumor Effects of Systemic and Local Immunization with a CTL-Directed Peptide in Combination with a Local Injection of OK-432
Clin. Cancer Res., February 15, 2006; 12(4): 1325 - 1332.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Yamada, H. Yano, Y. Takao, T. Ono, T. Matsumoto, and K. Itoh
Nonmutated Self-Antigen-Derived Cancer Vaccine Peptides Elicit an IgE-Independent but Mast Cell-Dependent Immediate-Type Skin Reaction without Systemic Anaphylaxis
J. Immunol., January 15, 2006; 176(2): 857 - 863.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Matsueda, H. Takedatsu, A. Yao, M. Tanaka, M. Noguchi, K. Itoh, and M. Harada
Identification of Peptide Vaccine Candidates for Prostate Cancer Patients with HLA-A3 Supertype Alleles
Clin. Cancer Res., October 1, 2005; 11(19): 6933 - 6943.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Yajima, R. Yamanaka, T. Mine, N. Tsuchiya, J. Homma, M. Sano, T. Kuramoto, Y. Obata, N. Komatsu, Y. Arima, et al.
Immunologic Evaluation of Personalized Peptide Vaccination for Patients with Advanced Malignant Glioma
Clin. Cancer Res., August 15, 2005; 11(16): 5900 - 5911.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Yoshitake, T. Nakatsura, M. Monji, S. Senju, H. Matsuyoshi, H. Tsukamoto, S. Hosaka, H. Komori, D. Fukuma, Y. Ikuta, et al.
Proliferation Potential-Related Protein, an Ideal Esophageal Cancer Antigen for Immunotherapy, Identified Using Complementary DNA Microarray Analysis
Clin. Cancer Res., October 1, 2004; 10(19): 6437 - 6448.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. Azuma, T. Sasada, H. Takedatsu, H. Shomura, M. Koga, Y. Maeda, A. Yao, T. Hirai, A. Takabayashi, S. Shichijo, et al.
Ran, a Small GTPase Gene, Encodes Cytotoxic T Lymphocyte (CTL) Epitopes Capable of Inducing HLA-A33-restricted and Tumor-Reactive CTLs in Cancer Patients
Clin. Cancer Res., October 1, 2004; 10(19): 6695 - 6702.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Monji, T. Nakatsura, S. Senju, Y. Yoshitake, M. Sawatsubashi, M. Shinohara, T. Kageshita, T. Ono, A. Inokuchi, and Y. Nishimura
Identification of a Novel Human Cancer/Testis Antigen, KM-HN-1, Recognized by Cellular and Humoral Immune Responses
Clin. Cancer Res., September 15, 2004; 10(18): 6047 - 6057.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Shichijo, K. Azuma, N. Komatsu, M. Ito, Y. Maeda, Y. Ishihara, and K. Itoh
Two Proliferation-Related Proteins, TYMS and PGK1, Could Be New Cytotoxic T Lymphocyte-Directed Tumor-Associated Antigens of HLA-A2+ Colon Cancer
Clin. Cancer Res., September 1, 2004; 10(17): 5828 - 5836.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
T. Mine, Y. Sato, M. Noguchi, T. Sasatomi, R. Gouhara, N. Tsuda, S. Tanaka, H. Shomura, K. Katagiri, T. Rikimaru, et al.
Humoral Responses to Peptides Correlate with Overall Survival in Advanced Cancer Patients Vaccinated with Peptides Based on Pre-existing, Peptide-Specific Cellular Responses
Clin. Cancer Res., February 1, 2004; 10(3): 929 - 937.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Takedatsu, S. Shichijo, K. Katagiri, H. Sawamizu, M. Sata, and K. Itoh
Identification of Peptide Vaccine Candidates Sharing among HLA-A3+, -A11+, -A31+, and -A33+ Cancer Patients
Clin. Cancer Res., February 1, 2004; 10(3): 1112 - 1120.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
C. Maccalli, Y. F. Li, M. El-Gamil, S. A. Rosenberg, and P. F. Robbins
Identification of a Colorectal Tumor-Associated Antigen (COA-1) Recognized by CD4+ T Lymphocytes
Cancer Res., October 15, 2003; 63(20): 6735 - 6743.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Yamada, K. Kawano, M. Koga, S. Takamori, M. Nakagawa, and K. Itoh
Gene and Peptide Analyses of Newly Defined Lung Cancer Antigens Recognized by HLA-A2402-restricted Tumor-specific Cytotoxic T Lymphocytes
Cancer Res., June 1, 2003; 63(11): 2829 - 2835.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. Salgia, T. Lynch, A. Skarin, J. Lucca, C. Lynch, K. Jung, F. S. Hodi, M. Jaklitsch, S. Mentzer, S. Swanson, et al.
Vaccination With Irradiated Autologous Tumor Cells Engineered to Secrete Granulocyte-Macrophage Colony-Stimulating Factor Augments Antitumor Immunity in Some Patients With Metastatic Non-Small-Cell Lung Carcinoma
J. Clin. Oncol., February 15, 2003; 21(4): 624 - 630.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Liu, J. Li, B. O. Kim, B. S. Pace, and J. J. He
HIV-1 Tat Protein-mediated Transactivation of the HIV-1 Long Terminal Repeat Promoter Is Potentiated by a Novel Nuclear Tat-interacting Protein of 110 kDa, Tip110
J. Biol. Chem., June 21, 2002; 277(26): 23854 - 23863.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Hirohashi, T. Torigoe, A. Maeda, Y. Nabeta, K. Kamiguchi, T. Sato, J. Yoda, H. Ikeda, K. Hirata, N. Yamanaka, et al.
An HLA-A24-restricted Cytotoxic T Lymphocyte Epitope of a Tumor-associated Protein, Survivin
Clin. Cancer Res., June 1, 2002; 8(6): 1731 - 1739.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
Y. Miyagi, N. Imai, T. Sasatomi, A. Yamada, T. Mine, K. Katagiri, M. Nakagawa, A. Muto, S. Okouchi, H. Isomoto, et al.
Induction of Cellular Immune Responses to Tumor Cells and Peptides in Colorectal Cancer Patients by Vaccination with SART3 Peptides
Clin. Cancer Res., December 1, 2001; 7(12): 3950 - 3962.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Kuzushima, N. Hayashi, H. Kimura, and T. Tsurumi
Efficient identification of HLA-A*2402-restricted cytomegalovirus-specific CD8+ T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay
Blood, September 15, 2001; 98(6): 1872 - 1881.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
A. Yamada, K. Kawano, M. Koga, T. Matsumoto, and K. Itoh
Multidrug Resistance-associated Protein 3 Is a Tumor Rejection Antigen Recognized by HLA-A2402-restricted Cytotoxic T Lymphocytes
Cancer Res., September 1, 2001; 61(17): 6459 - 6466.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Ito, S. Shichijo, N. Tsuda, M. Ochi, N. Harashima, N. Saito, and K. Itoh
Molecular Basis of T Cell-mediated Recognition of Pancreatic Cancer Cells
Cancer Res., March 1, 2001; 61(5): 2038 - 2046.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
S. Nishizaka, S. Gomi, K. Harada, K. Oizumi, K. Itoh, and S. Shichijo
A New Tumor-Rejection Antigen Recognized by Cytotoxic T Lymphocytes Infiltrating into a Lung Adenocarcinoma
Cancer Res., September 1, 2000; 60(17): 4830 - 4837.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
T. K. Hoffmann, N. Meidenbauer, G. Dworacki, H. Kanaya, and T. L. Whiteside
Generation of Tumor-specific T Lymphocytes by Cross-Priming with Human Dendritic Cells Ingesting Apoptotic Tumor Cells
Cancer Res., July 1, 2000; 60(13): 3542 - 3549.
[Abstract] [Full Text]

Home page
 Cancer Res.Home page
K. Kawano, S. Gomi, K. Tanaka, N. Tsuda, T. Kamura, K. Itoh, and A. Yamada
Identification of a New Endoplasmic Reticulum-resident Protein Recognized by HLA-A24-restricted Tumor-infiltrating Lymphocytes of Lung Cancer
Cancer Res., July 1, 2000; 60(13): 3550 - 3558.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
M. Nakao, S. Shichijo, T. Imaizumi, Y. Inoue, K. Matsunaga, A. Yamada, M. Kikuchi, N. Tsuda, K. Ohta, S. Takamori, et al.
Identification of a Gene Coding for a New Squamous Cell Carcinoma Antigen Recognized by the CTL
J. Immunol., March 1, 2000; 164(5): 2565 - 2574.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cancer Prevention Research
Cancer Prevention Journals Portal Cancer Reviews Online
Annual Meeting Education Book Meeting Abstracts Online
Copyright © 1999 by the American Association for Cancer Research.